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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

4 Issues per year

CiteScore 2017: 1.46

SCImago Journal Rank (SJR) 2017: 0.531
Source Normalized Impact per Paper (SNIP) 2017: 0.645

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Volume 27, Issue 1


Pharmacokinetic interactions of selective serotonin reuptake inhibitors with other commonly prescribed drugs in the era of pharmacogenomics

Vangelis G. Manolopoulos
  • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
  • Clinical Pharmacology Unit, Academic General Hospital of Alexandroupolis, Alexandroupolis, Greece
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/ Georgia Ragia
  • Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
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/ Georgios Alevizopoulos
  • Department of Psychiatry, Agioi Anargyroi General Hospital, Faculty of Nursing, University of Athens, Athens, Greece
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Published Online: 2012-02-29 | DOI: https://doi.org/10.1515/dmdi-2011-0033


Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed to treat depression and a broad range of other comorbidities. The increased use of SSRIs in patients with various comorbidities treated with different drugs engenders the risk of pharmacokinetic drug interactions via cytochrome P450 (CYP450) enzymes inhibition. In the present review, we provide an overview of documented clinically significant drug interactions between SSRIs and other drugs co-prescribed in psychiatric patients for the same or other diseases. We further discuss the significance of drug interactions in the era of pharmacogenomics to underline the need for using information on both genotype and drug interactions towards implementing better clinical outcomes through personalized medicine.

Keywords: comorbidities; CYP450 enzymes; drug interactions; pharmacogenomics; pharmacokinetics; selective serotonin reuptake inhibitors

About the article

Corresponding author: Dr. Vangelis G. Manolopoulos, Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece Phone/Fax: +30-2551-030523

Received: 2011-09-28

Accepted: 2012-01-23

Published Online: 2012-02-29

Published in Print: 2012-03-01

Citation Information: Drug Metabolism and Drug Interactions, Volume 27, Issue 1, Pages 19–31, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: https://doi.org/10.1515/dmdi-2011-0033.

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