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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board Member: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario D. C. / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

SCImago Journal Rank (SJR) 2015: 0.447
Source Normalized Impact per Paper (SNIP) 2015: 0.524
Impact per Publication (IPP) 2015: 1.329

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Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds

Vijay Kumar Vishvakarma1 / 1, 2 / Monica Dubey3 / Kamlesh Kumari3 / Ramesh Chandra4 / Narender D. Pandey3

1Department of Applied Chemistry, BBA University, Lucknow, Uttar Pradesh, India

2A.R.S.D. College, University of Delhi, New Delhi, India

3Department of Chemistry, MNNIT Allahabad, Uttar Pradesh, India

4ACBR, University of Delhi, New Delhi, India

Corresponding author: Prashant Singh, Department of Applied Chemistry, BBA University, Lucknow Uttar Pradesh 226025, India

Citation Information: Drug Metabolism and Drug Interactions. Volume 28, Issue 1, Pages 31–47, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: https://doi.org/10.1515/dmdi-2012-0036, February 2013

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Background: Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.

Methods: In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.

Results and conclusions: Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.

Keywords: antidiabetic; drug design; peroxisome proliferator activated receptors (PPARs); quantitative structure-activity relationship (QSAR); quantum chemistry descriptors; thiazolidineones

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