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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

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2363-8915
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Volume 31, Issue 4

Issues

CYP2D6 variability in populations from Venezuela

Nancy Moreno
  • Corresponding author
  • Universidad de Carabobo Facultad de Ciencias de la Salud – Escuela de Medicina (Sede Aragua) – Sección de Polimorfismos Genómicos del Instituto de investigaciones Biomédicas “Dr. Francisco J. Triana Alonso”, Maracay 2102, Venezuela, Venezuela (Bolivarian Republic of)
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Carlos Flores-Angulo
  • Universidad de Carabobo Facultad de Ciencias de la Salud – Escuela de Medicina (Sede Aragua) – Sección de Polimorfismos Genómicos del Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso”, Maracay, Venezuela, Venezuela (Bolivarian Republic of)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Cecilia Villegas
  • Universidad de Carabobo Facultad de Ciencias de la Salud – Escuela de Medicina (Sede Aragua) – Maestría en Ciencias Biomédicas, Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso”, Final de la calle Cecilio Acosta Las Delicias, Maracay, Aragua 2102, Venezuela, Venezuela (Bolivarian Republic of)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yuselin Mora
  • Universidad de Carabobo Facultad de Ciencias de la Salud – Escuela de Medicina (Sede Aragua) – Maestría en Ciencias Biomédicas, Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso”, Final de la calle Cecilio Acosta Las Delicias, Maracay, Aragua 2102, Venezuela, Venezuela (Bolivarian Republic of)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-11-22 | DOI: https://doi.org/10.1515/dmpt-2016-0023

Abstract

CYP2D6 is an important cytochrome P450 enzyme that plays an important role in the metabolism of about 25% of currently prescribed drugs. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatments. The most prevalent diseases in the admixed population from Venezuela are cardiovascular and cancer, whereas viral, bacterial and parasitic diseases, particularly malaria, are prevalent in Amerindian populations; in the treatment of these diseases, several drugs that are metabolized by CYP2D6 are used. In this work, we reviewed the data on CYP2D6 variability and predicted metabolizer phenotypes, in healthy volunteers of two admixed and five Amerindian populations from Venezuela. The Venezuelan population is very heterogeneous as a result of the genetic admixture of three major ethnical components: Europeans, Africans and Amerindians. There are noticeable inter-regional and inter-population differences in the process of mixing of this population. Hitherto, there are few published studies in Venezuela on CYP2D6; therefore, it is necessary to increase research in this regard, in particular to develop studies with a larger sample size. There is a considerable amount of work remaining before CYP2D6 is integrated into clinical practice in Venezuela.

Keywords: CYP2D6; malaria; pharmacogenetics; predicted phenotypes; Venezuela

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About the article

Received: 2016-07-23

Accepted: 2016-11-02

Published Online: 2016-11-22

Published in Print: 2016-12-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved the submission.

Research funding: This study was financed by Fondo Nacional de Ciencia y Tecnología (FONACIT) through of the project N° 2012001248.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Drug Metabolism and Personalized Therapy, Volume 31, Issue 4, Pages 181–189, ISSN (Online) 2363-8915, ISSN (Print) 2363-8907, DOI: https://doi.org/10.1515/dmpt-2016-0023.

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