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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

CiteScore 2018: 1.01

SCImago Journal Rank (SJR) 2018: 0.277
Source Normalized Impact per Paper (SNIP) 2018: 0.446

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Volume 32, Issue 3


Need for pharmacogenetic studies on the prevalence of MTHFR mutations in Puerto Ricans and Hispanics

Raúl H. Morales-Borges
  • Corresponding author
  • President and Principal Investigator, Integrative Optimal Health of Puerto Rico, New Alliance Integrative Research, 29 Washington St. Suite # 107, San Juan, 00907-1509, Puerto Rico, Phone: (787) 722-0412, Fax: (787) 723-0554, E-mail:
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Published Online: 2017-09-01 | DOI: https://doi.org/10.1515/dmpt-2017-0010


Methylenetetrahydrofolate reductase (MTHFR) mutations have been linked to many diseases. Evidence has been provided to prove that we need to perform pharmacogenetic studies regarding the prevalence of MTHFR mutations and diseases, risks, and the impact on folate requirement in general, but little has been published about Puerto Ricans. A multi center cross-sectional retrospective review study or a prospective pharmacogenetic study of valid genotypes and phenotypes of MTHFR mutations within the different populations of Puerto Ricans and Hispanics are recommended, because differences within them and within the general population are expected.

Keywords: Hispanics; MTHFR; mutation; pharmacogenetics; Puerto Ricans


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About the article

Corresponding author: Raúl H. Morales-Borges, MD, President and Principal Investigator, Integrative Optimal Health of Puerto Rico, New Alliance Integrative Research, 29 Washington St. Suite # 107, San Juan, 00907-1509, Puerto Rico, Phone: (787) 722-0412, Fax: (787) 723-0554

Received: 2017-03-12

Accepted: 2017-08-03

Published Online: 2017-09-01

Published in Print: 2017-09-26

Author contributions: The author has accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Drug Metabolism and Personalized Therapy, Volume 32, Issue 3, Pages 169–171, ISSN (Online) 2363-8915, ISSN (Print) 2363-8907, DOI: https://doi.org/10.1515/dmpt-2017-0010.

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