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Diagnosis

Official Journal of the Society to Improve Diagnosis in Medicine (SIDM)

Editor-in-Chief: Graber, Mark L. / Plebani, Mario

Ed. by Argy, Nicolas / Epner, Paul L. / Lippi, Giuseppe / Singhal, Geeta / McDonald, Kathryn / Singh, Hardeep / Newman-Toker, David

Editorial Board: Basso , Daniela / Crock, Carmel / Croskerry, Pat / Dhaliwal, Gurpreet / Ely, John / Giannitsis, Evangelos / Katus, Hugo A. / Laposata, Michael / Lyratzopoulos, Yoryos / Maude, Jason / Sittig, Dean F. / Sonntag, Oswald / Zwaan, Laura


CiteScore 2018: 0.69

SCImago Journal Rank (SJR) 2018: 0.359
Source Normalized Impact per Paper (SNIP) 2018: 0.424

Online
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2194-802X
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The kinetics of haemoglobin and ferritin in longitudinal community patients with iron deficiency or hypoxia

Tony Badrick
  • Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, Australia
  • Sullivan Nicolaides Pathology, Taringa, Brisbane, Queensland, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alice M. RichardsonORCID iD: http://orcid.org/0000-0001-7084-1524
  • Corresponding author
  • National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 0200, Australia
  • Genomics and Predictive Medicine, Department of Genome Sciences, The John Curtin School of Medical Research, ANU, Canberra, Australia
  • orcid.org/0000-0001-7084-1524
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ashley Arnott / Brett A. Lidbury
  • Genomics and Predictive Medicine, Department of Genome Sciences, The John Curtin School of Medical Research, ANU, Canberra, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-11-23 | DOI: https://doi.org/10.1515/dx-2016-0031

Abstract

Background:

Red cell distribution width (RDW) is well recognised as a marker of iron-deficient anaemia, as well as useful to the distinction between some anaemic states. A role in the prediction of patient mortality and for the laboratory diagnosis of organ dysfunction has been also investigated. RDW has recently been suggested as a marker of acute and chronic hypoxia.

Methods:

In this paper we use RDW kinetics to identify different patient groups and then investigate the relationship between RDW, ferritin and haemoglobin kinetics in a large cross-sectional community patient dataset.

Results:

A novel mathematical model of this relationship is developed that captures all aspects of variation in the data. A linear regression of RDW/log(ferritin) on days is combined with a multi-level random structure including random intercepts and slopes for each patient.

Conclusions:

No evidence of an age affect was found in the data. On the other hand, significant patterns in the rises and falls of log(ferritin) and haemoglobin with RDW over time are identified.

Keywords: fixed effects; multilevel model; random effects

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About the article

Corresponding author: Dr. Alice M. Richardson, National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 0200, Australia; and Genomics and Predictive Medicine, Department of Genome Sciences, The John Curtin School of Medical Research, ANU, Canberra, Australia

aPresent address: Chief Executive RCPAQAP, Suite 201/8 Herbert Street, St Leonards, NSW 2065, Australia

bPresent address: National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 2601, Australia


Received: 2016-07-25

Accepted: 2016-10-01

Published Online: 2016-11-23

Published in Print: 2017-03-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Diagnosis, Volume 4, Issue 1, Pages 35–41, ISSN (Online) 2194-802X, ISSN (Print) 2194-8011, DOI: https://doi.org/10.1515/dx-2016-0031.

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