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Official Journal of the Society to Improve Diagnosis in Medicine (SIDM)

Editor-in-Chief: Graber, Mark L. / Plebani, Mario

Ed. by Argy, Nicolas / Epner, Paul L. / Lippi, Giuseppe / Singhal, Geeta / McDonald, Kathryn / Singh, Hardeep / Newman-Toker, David

Editorial Board: Basso , Daniela / Crock, Carmel / Croskerry, Pat / Dhaliwal, Gurpreet / Ely, John / Giannitsis, Evangelos / Katus, Hugo A. / Laposata, Michael / Lyratzopoulos, Yoryos / Maude, Jason / Sittig, Dean F. / Sonntag, Oswald / Zwaan, Laura

CiteScore 2018: 0.69

SCImago Journal Rank (SJR) 2018: 0.359
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Aseptic myonecrosis following intramuscular benzathine penicllin G injection: a novel syndrome

Nicholas Ryan / Andrew Olson
  • Departments of Pediatrics and Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-02-21 | DOI: https://doi.org/10.1515/dx-2016-0040


We report a novel syndrome of aseptic myonecrosis in a child occurring after intramuscular (IM) benzathine penicillin G injection for the treatment of streptococcal pharyngitis. Common side effects of IM injection, including transient injection site pain and inflammation, are common and well described. However, isolated myonecrosis following IM injection in the pediatric patient has not been previously reported. Only one similar case, following IM diclofenac injection, has been discussed in the adult literature.

Keywords: adverse event; aseptic myonecrosis; Nicolau syndrome; side effect


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About the article

Corresponding author: Nicholas Ryan, DO, MS, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA, Phone: + 612-624-3113

Received: 2016-10-29

Accepted: 2017-01-02

Published Online: 2017-02-21

Published in Print: 2017-03-01

Author contributions: Andrew Olson: Dr. Olson critically reviewed the manuscript and approved the final manuscript. Nicholas Ryan: Dr. Ryan drafted and edited the initial manuscript and approved the final manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Diagnosis, Volume 4, Issue 1, Pages 51–54, ISSN (Online) 2194-802X, ISSN (Print) 2194-8011, DOI: https://doi.org/10.1515/dx-2016-0040.

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