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Official Journal of the Society to Improve Diagnosis in Medicine (SIDM)

Editor-in-Chief: Graber, Mark L. / Plebani, Mario

Ed. by Argy, Nicolas / Epner, Paul L. / Lippi, Giuseppe / Singhal, Geeta / McDonald, Kathryn / Singh, Hardeep / Newman-Toker, David

Editorial Board: Basso , Daniela / Crock, Carmel / Croskerry, Pat / Dhaliwal, Gurpreet / Ely, John / Giannitsis, Evangelos / Katus, Hugo A. / Laposata, Michael / Lyratzopoulos, Yoryos / Maude, Jason / Sittig, Dean F. / Sonntag, Oswald / Zwaan, Laura

CiteScore 2018: 0.69

SCImago Journal Rank (SJR) 2018: 0.359
Source Normalized Impact per Paper (SNIP) 2018: 0.424

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Macro-CK type 2 in metastatic prostate cancer

Abass Eidizadeh
  • Corresponding author
  • Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Institut für Klinische Chemie, Robert-Koch-Str. 40, 37075 Göttingen, Germany, Phone: 0551 39-8549
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/ Nicolas von Ahsen / Steffen Friedewald / Lutz Binder
Published Online: 2018-11-09 | DOI: https://doi.org/10.1515/dx-2018-0039


The isoenzyme creatine kinase muscle/brain (CK-MB) still plays an important role for the differential diagnosis of CK elevations and the clarification of their origin from heart or skeletal muscle. Therefore, it is necessary to know the diagnostic pitfalls in interpreting CK-MB results. We demonstrate a case of macro-CK type 2 in a 75-year-old patient with metastatic castration-resistant prostate cancer and its identification by isoenzyme electrophoresis, which can be typical for cancer diseases.

Keywords: agarose gel electrophoresis; castration-resistant; CK; CK isoenzyme; CK-MB; creatine kinase; immunoinhibition assay; macro-CK; metastatic; prostate cancer


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About the article

Received: 2018-07-14

Accepted: 2018-10-11

Published Online: 2018-11-09

Published in Print: 2019-08-27

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Diagnosis, Volume 6, Issue 3, Pages 307–309, ISSN (Online) 2194-802X, ISSN (Print) 2194-8011, DOI: https://doi.org/10.1515/dx-2018-0039.

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