Jump to ContentJump to Main Navigation
Show Summary Details
More options …

The EuroBiotech Journal


4 Issues per year

Open Access
See all formats and pricing
More options …

Familial aneurysms of great vessels in young people

Bruno Amato
  • Corresponding author
  • Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rita Compagna
  • Department of Cardio-Thoracic and Respiratory Sciences, University of Campania “Luigi Vanvitelli”, Caserta. Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anna Florio
  • Department of Cardio-Thoracic and Respiratory Sciences, University of Campania “Luigi Vanvitelli”, Caserta. Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-12-28 | DOI: https://doi.org/10.24190/ISSN2564-615X/2017/S2.02


The major structural proteins of the vascular wall are collagen and elastin. Genetic connective tissue diseases lead to degeneration, aneurysms and spontaneous dissection or rupture of arteries. The best-known are Marfan syndrome, vascular Ehlers-Danlos syndrome (type IV), Loeys-Dietz syndrome and familial aortic aneurysms and dissections. Objective. This review addresses the current status of endovascular treatment options for major connective tissue diseases. The treatment of choice for patients who are mostly affected at a young age is primarily conservative or open repair. There is only limited evidence in favour of endovascular aortic repair (EVAR) of abdominal aneurysms or thoracic endovascular aortic repair (TEVAR) because disease progression and dilation leads to secondary endoleaks and high reintervention rates with uncertain long-term results. There is therefore consensus that EVAR and TEVAR should be limited to exceptional cases and emergency situations in patients with genetic aortic diseases.

Keywords: aneurysm; young people; dissection; thoracic; abdominal


  • 1. Groth KA, Stochholm K, Hove H, Kyhl K, Gregersen PA, Vejlstrup N, Østergaard JR, Gravholt CH, Andersen NH. Aortic events in a nationwide Marfan syndrome cohort. Clin Res Cardiol. 2017 Feb;106(2):105-112.Google Scholar

  • 2. Amato B, Compagna R, Amato M, Grande R, Butrico L, Rossi A, Naso A, Ruggiero M, de Franciscis S, Serra R. Adult vascular wall resident multipotent vascular stem cells, matrix metalloproteinases, and arterial aneurysms. Stem Cells Int. 2015;2015:434962.Web of ScienceGoogle Scholar

  • 3. Preventza O, Mohammed S, Cheong BY, Gonzalez L, Ouzounian M, Livesay JJ, Cooley DA, Coselli JS. Endovascular therapy in patients with genetically triggered thoracic aortic disease: applications and short- and mid-term outcomes. Eur J Cardiothorac Surg. 2014 Aug;46(2):248-53CrossrefGoogle Scholar

  • 4. Serra R, Butrico L, Grande R, Placida GD, Rubino P, Settimio UF, Quarto G, Amato M, Furino E, Compagna R, Amato B, Gallelli L, de Franciscis S. Venous aneurysm complicating arteriovenous fistula access and matrix metalloproteinases. Open Med (Wars). 2015 Dec 17;10(1):519-522.Google Scholar

  • 5. Johns N, Jamieson RW, Ceresa C, Moores C, Nimmo AF, Falah O, Burns PJ, Chalmers RT. Contemporary outcomes of open repair of thoracoabdominal aortic aneurysm in young patients. J Cardiothorac Surg. 2014 Dec 10;9:195.Web of ScienceCrossrefGoogle Scholar

  • 6. De Caridi G, Massara M, Spinelli F, Grande R, Butrico L, Rende P, Amato M, Compagna R, Amato B, de Franciscis S, Serra R. An uncommon case of arterial aneurysms association with high plasma levels of matrix metalloproteinase-9 and neutrophil gelatinase-associated lipocalin. Open Med (Wars). 2015 Dec 17;10(1):492-497.Google Scholar

  • 7. Amato B, Esposito G, Serra R, Compagna R, Vigliotti G, Bianco T, Massa G, Amato M, Massa S, Aprea G. One-step mini-invasive treatment of abdominal aortic-iliac aneurysm associated with colo- rectal cancer. Int J Surg. 2014;12 Suppl 2:S193-S196.Web of ScienceGoogle Scholar

  • 8. Mannacio V, Mottola M, Ruggiero D, D’Alessio A, Surace GG, Di Tommaso E, Amato B, Iannelli G. Treatment of a rapidly expanding thoracoabdominal aortic aneurysm after endovascular repair of descending thoracic aortic aneurysm in an old patient. BMC Surg. 2012;12 Suppl 1:S26.Web of ScienceGoogle Scholar

  • 9. Giugliano G, Laurenzano E, Rengo C, De Rosa G, Brevetti L, Sanni no A, Perrino C, Chiariotti L, Schiattarella GG, Serino F, Ferrone M, Scudiero F, Carbone A, Sorropago A, Amato B, Trimarco B, Esposito G. Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors. BMC Surg. 2012;12 Suppl 1:S17.Web of ScienceGoogle Scholar

  • 10. Romano M, Mainenti PP, Imbriaco M, Amato B, Markabaoui K, Tamburrini O, Salvatore M. Multidetector row CT angiography of the abdominal aorta and lower extremities in patients with peripheral arterial occlusive disease: diagnostic accuracy and interobserver agreement. Eur J Radiol. 2004 Jun;50(3):303-8.Google Scholar

About the article

Published Online: 2017-12-28

Published in Print: 2017-12-28

Citation Information: The EuroBiotech Journal, Volume 1, Issue s2, Pages 119–121, ISSN (Online) 2564-615X, DOI: https://doi.org/10.24190/ISSN2564-615X/2017/S2.02.

Export Citation

© 2018. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

Comments (0)

Please log in or register to comment.
Log in