Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker

Editorial Board Member: Akay, Galip / Arends, Isabel / Cann, Michael C. / Cheng, Yi / Cravotto, Giancarlo / Gruber-Wölfler, Heidrun / Kralisch, Dana / D. P. Nigam, Krishna / Saha, Basudeb / Serra, Christophe A. / Zhang, Wei

6 Issues per year


IMPACT FACTOR 2016: 0.782

CiteScore 2016: 0.90

SCImago Journal Rank (SJR) 2015: 0.344
Source Normalized Impact per Paper (SNIP) 2015: 0.402

Online
ISSN
2191-9550
See all formats and pricing
More options …
Volume 1, Issue 2 (Apr 2012)

Issues

Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium

Ramesh A. Joshi / Rohini R. Joshi / Jagdish Tibhe
  • Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nayana T. Nivangune
  • Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amol A. Kulkarni

Abstract

Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology.

Keywords: β-amino crotonate; continuous flow synthesis; Hantzsch synthesis; microreactor

About the article

Corresponding author


Received: 2012-01-30

Accepted: 2012-03-06

Published in Print: 2012-04-01


Citation Information: Green Processing and Synthesis, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2011-0002.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ranjeet P. Utikar and Vivek V. Ranade
ACS Sustainable Chemistry & Engineering, 2017, Volume 5, Number 5, Page 3607

Comments (0)

Please log in or register to comment.
Log in