Jump to ContentJump to Main Navigation
Show Summary Details

Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker

Editorial Board Member: Akay, Galip / Arends, Isabel / Cann, Michael C. / Cheng, Yi / Cravotto, Giancarlo / Gruber-Wölfler, Heidrun / Kralisch, Dana / D. P. Nigam, Krishna / Saha, Basu / Serra, Christophe A. / Zhang, Wei

6 Issues per year


IMPACT FACTOR increased in 2015: 1.291

SCImago Journal Rank (SJR) 2015: 0.344
Source Normalized Impact per Paper (SNIP) 2015: 0.402
Impact per Publication (IPP) 2015: 1.189

Online
ISSN
2191-9550
See all formats and pricing
Volume 1, Issue 2 (Apr 2012)

Continuous flow synthesis of β-amino α, β-unsaturated esters in aqueous medium

Ramesh A. Joshi
  • Organic Chemistry Division, National Chemical Laboratory, Pune, 411008, India
/ Rohini R. Joshi
  • Organic Chemistry Division, National Chemical Laboratory, Pune, 411008, India
/ Jagdish Tibhe
  • Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, India
/ Nayana T. Nivangune
  • Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, India
/ Amol A. Kulkarni
  • Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, 411008, India
  • Email:

Abstract

Continuous flow synthesis of many β-amino α, β-unsaturated esters has been demonstrated, through the reaction of a β-ketoester compound with ammonia and primary amines. Several combinations have been studied in detail in batch mode and a few have been taken for continuous flow synthesis based on their suitability. Upon studying the feasibility of continuous flow synthesis of different β-amino crotonates, the synthesis of methyl amino crotonate in the presence of a recyclable and reusable homogeneous acid catalyst has been studied in detail. Tubular reactors were seen to overcome the heat and mass transfer limitations, thereby providing a simple device for even a pilot scale production. A similar approach can be used for the synthesis of other β-amino crotonates. The continuous flow synthesis approach for producing methyl amino crotonate, in the absence of any external solvent, makes it a green process technology.

Keywords: β-amino crotonate; continuous flow synthesis; Hantzsch synthesis; microreactor

About the article

Corresponding author


Received: 2012-01-30

Accepted: 2012-03-06

Published in Print: 2012-04-01


Citation Information: Green Processing and Synthesis, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2011-0002. Export Citation

Comments (0)

Please log in or register to comment.
Log in