Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker

Editorial Board: Akay, Galip / Arends, Isabel W.C.E. / Cann, Michael C. / Cheng, Yi / Cravotto, Giancarlo / Gruber-Wölfler, Heidrun / Kralisch, Dana / D. P. Nigam, Krishna / Saha, Basudeb / Serra, Christophe A. / Zhang, Wei

6 Issues per year


IMPACT FACTOR 2017: 0.736
5-year IMPACT FACTOR: 1.170

CiteScore 2017: 0.64

SCImago Journal Rank (SJR) 2017: 0.247
Source Normalized Impact per Paper (SNIP) 2017: 0.348

Online
ISSN
2191-9550
See all formats and pricing
More options …
Volume 1, Issue 4

Issues

Large microchannel emulsification device for mass producing uniformly sized droplets on a liter per hour scale

Isao Kobayashi
  • Corresponding author
  • Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcos A. Neves
  • Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
  • Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yoshihiro Wada / Kunihiko Uemura
  • Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mitsutoshi Nakajima
  • Corresponding author
  • Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
  • Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-07-28 | DOI: https://doi.org/10.1515/gps-2012-0023

Abstract

We report the mass production of uniformly sized droplets on a liter per hour scale using a large microchannel (MC) emulsification device developed in this study. This MC emulsification device includes a newly designed 40×40-mm silicon MC array chip with 24,772 asymmetric MCs, each consisting of a circular microhole (17-μm diameter and 200-μm depth) and a microslot (17×119-μm cross-section and 60-μm depth). The oil-in-water (O/W) system was composed of n-tetradecane as the dispersed phase and a Milli-Q water solution containing 2.0 wt% Tween-20 as the continuous phase. The MC emulsification results demonstrated the stable mass production of uniformly sized oil droplets with average diameters of 87 μm and coefficients of variation below 2% over a wide range of volumetric flow rates of the dispersed phase up to 1.4 l/h. Analyses of shear stress at the chip surface and droplet generation via an asymmetric MC verified that the resultant droplet size and size distribution was not influenced by the volumetric flow rate of each phase. The large MC emulsification device has a potential droplet productivity exceeding several tons per year, which could satisfy a minimum industrial-scale production of monodisperse microdispersions containing emulsion droplets, microparticles, and microcapsules.

Keywords: asymmetric microchannel; droplet generation; mass production; microchannel emulsification; monodisperse emulsion

References

  • [1]

    Harvkamp V, Ehrfeld W, Gebauer K, Hessel V, Löwe H, Richter T, Wille C. Fresenius J. Anal. Chem. 1999, 364, 617–624Google Scholar

  • [2]

    Mae K, Maki T, Hasegawa I, Eto U, Mizutani Y, Honda N. Chem. Eng. J. 2004, 101, 31–38Google Scholar

  • [3]

    Thorsen T, Roberts EW, Arnold FH, Quake SR. Phys. Rev. Lett. 2001, 86, 4163–4166PubMedGoogle Scholar

  • [4]

    Anna SL, Bontoux N, Stone HA. Appl. Phys. Lett. 2002, 82, 364–366Google Scholar

  • [5]

    Utada AS, Chu L-Y, Fernandez-Nieves A, Link DR, Holtze C, Weitz DA. MRS Bull. 2007, 32, 702–708Google Scholar

  • [6]

    Shui L, Eijkel JCT, ven der Berg A. Adv. Colloid Interface. Sci. 2007, 133, 35–49Google Scholar

  • [7]

    Teh S-Y, Lin R, Hung L-H, Lee AP. Lab. Chip. 2008, 8, 198–220PubMedGoogle Scholar

  • [8]

    Seemann R, Brinkmann M, Herminghaus S. Rep. Prog. Phys. 2012, 75, 016601PubMedGoogle Scholar

  • [9]

    Vladisavljević GT, Kobayashi I, Nakajima M. Microfluid. Nanofluid. 2012, 13, 151–178Google Scholar

  • [10]

    Kawakatsu T, Kikuchi Y, Nakajima M. J. Am. Oil Chem. Soc. 1997, 74, 317–321Google Scholar

  • [11]

    Kobayashi I, Mukataka S, Nakajima M. Langmuir 2005, 21, 7629–7632PubMedGoogle Scholar

  • [12]

    Nishisako T, Okushima S, Torii T. Soft Matter 2004, 1, 23–27Google Scholar

  • [13]

    Xu S, Nie Z, Seo M, Lewis P, Kumacheva E, Stone HA, Garstecki P, weibel DB, Gitlin I, Whitesides GM. Angew. Chem. Int. Ed. 2005, 44, 724–728Google Scholar

  • [14]

    Seo M, Nie Z, Xu S, Mok M, Lewis PC, Graham R, Kumacheva E. Langmuir 2005, 21, 11614–11622PubMedGoogle Scholar

  • [15]

    Utada AS, Lorenceau E, Link DR, Kaplan D, Stone HA, Weitz DA. Science 2005, 308, 537–541Google Scholar

  • [16]

    Nishisako T, Torii T. Adv. Mater. 2007, 19, 1489–1493Google Scholar

  • [17]

    Vladisavljević GT, Williams RA. Adv. Colloid Interface Sci. 2005, 113, 1–20PubMedGoogle Scholar

  • [18]

    Steegmann MLJ, Shroën KGPH, Boom RM. Langmuir 2009, 25, 3396–3401Google Scholar

  • [19]

    Nishisako T, Torii T. Lab. Chip. 2008, 8, 287–293Google Scholar

  • [20]

    Takeuchi S, Garstecki P, Weibel DB, Whitesides GM. Adv. Mater. 2005, 17, 1067–1072Google Scholar

  • [21]

    Yobas L, Martens S, Ong W-L, Ranganathan N. Lab. Chip. 2006, 6, 1073–1079PubMedGoogle Scholar

  • [22]

    Abate AR, Poitzsch A, Hwang Y, Lee J, Czewinska J, Weitz DA. Phys. Rev. E 2009, 80, 026310Google Scholar

  • [23]

    Li W, Young WK, Seo M, Nie Z, Kumacheva E. Soft Matter 2008, 4, 258–262Google Scholar

  • [24]

    Li W, Greener J, Voicu D, Kumacheva E. Lab. Chip. 2009, 9, 2715–2721PubMedGoogle Scholar

  • [25]

    Tetreadis-Meris G, Rossetti D, de Torres CP, Cao Rong, Lian G, Janes R. Ind. Eng. Chem. Res. 2009, 48, 8881–8889Google Scholar

  • [26]

    Romanowsky MB, Abate AR, Rotem A, Holtze C, Weitz DA. Lab. Chip. 2012, 12, 802–807PubMedGoogle Scholar

  • [27]

    Kobayashi I, Nakajima M, Chun K, Kikuchi Y, Fujita H. AIChE J. 2002, 48, 1639–1644Google Scholar

  • [28]

    Sugiura S, Nakajima M, Seki M. Langmuir 2002, 18, 3854–3859Google Scholar

  • [29]

    Sugiura S, Nakajima M, Iwamoto S, Seki M. Langmuir 2001, 106, 9405–9409Google Scholar

  • [30]

    Sugiura S, Kumazawa N, Nakajima M, Seki M. J. Phys. Chem. B 2002, 17, 5562–5566Google Scholar

  • [31]

    Kobayashi I, Hori Y, Uemura K, Nakajima M. Jpn. J. Food Eng. 2010, 11, 37–48Google Scholar

  • [32]

    Vladisavljević GT, Kobayashi I, Nakajima M. Microfluid. Nanofluid. 2011, 10, 1199–1209Google Scholar

  • [33]

    Nakashima T, Shimizu M, Kukizaki M. Adv. Drug Deliv. Rev. 2000, 45, 47–56PubMedGoogle Scholar

  • [34]

    Kukizaki M. J. Membr. Sci. 2009, 360, 426–435Google Scholar

  • [35]

    Kosvintsev SR, Gasparini G, Holdich RG, Cumming IW, Stillwell MT. J. Membr. Sci. 2008, 313, 182–189Google Scholar

  • [36]

    Vladisavljević GT, Schubert H. J. Membr. Sci. 2003, 225, 15–23Google Scholar

  • [37]

    Kobayashi I, Wada Y, Uemura K, Nakajima M. Microfluid. Nanofluid. 2010, 8, 255–262Google Scholar

  • [38]

    Kobayashi I, Vladisavljević GT, Uemura K, Nakajima M. Chem. Eng. Sci. 2011, 66, 5556–5565Google Scholar

  • [39]

    Kobayashi I, Mukataka S, Nakajima M. J. Colloid Interface Sci. 2004, 279, 277–280Google Scholar

  • [40]

    Kobayashi I, Mukataka S, Nakajima M. Langmuir 2005, 2, 5722–5730Google Scholar

  • [41]

    Kobayashi I, Nakajima M, Mukataka S. Colloids Surf. A Physicochem. Eng. Aspects 2003, 229, 33–41Google Scholar

  • [42]

    Kobayashi I, Takano T, Maeda R, Wada Y, Uemura K, Nakajima M. Microfluid. Nanofluid. 2008, 4, 167–177Google Scholar

  • [43]

    Van Dijke K, Kobayashi I, Shroën K, Uemura K, Nakajima M, Boom RM. Microfluid. Nanofluid. 2010, 9, 77–85Google Scholar

About the article

Isao Kobayashi

Isao Kobayashi was born in Gunma, Japan, in 1975. He received a PhD in Agricultural and Forest Engineering from the University of Tsukuba, Japan, in 2003. He worked on microchannel emulsification as a JSPS postdoctoral research fellow at the University of Tsukuba from 2003 to 2005. In 2005, he joined the National Food Research Institute, Japan as a researcher. Currently, he is a senior researcher at National Food Research Institute, NARO, Japan. He is the author and co-author of over 60 peer scientific articles. His current research interests include micro/nanofluidics, emulsification, food nanotechnology, and in vitro gastrointestinal digestion.

Marcos A. Neves

Marcos A. Neves was born in California, Paraná, Brazil, in 1971. Initially, he received a Bachelor degree in Food Engineering in Brazil, followed by a PhD in Agricultural Sciences from the University of Tsukuba, Japan, in 2006. After graduation, he worked as a research associate at the National Food Research Institute conducting research related to food micro/nanotechnology, where he remains as a visiting researcher to date. He joined the University of Tsukuba in 2007, working initially as a postdoctoral researcher. Since 2010, he has been working as an assistant professor at the same university. He is the co-author of 6 book chapters and over 20 peer reviewed scientific articles. His current research interests include development of bioactives delivery systems, emulsification and food micro/nanotechnology.

Yoshihiro Wada

Yoshihiro Wada was born in Ibaraki, Japan, in 1956. He graduated from Ibaraki National College of Technology, Japan, in 1977. He worked at Hitachi Haramachi Electronics Co., Ltd. from 1977 to 2002 and was a section manager from 1998 to 2002. In 2002, he joined EP Tech Co., Ltd. as a project manager. His current research interests include microchannel emulsification and micro/nano mechanical engineering.

Kunihiko Uemura

Kunihiko Uemura was born in Fukuoka, Japan, in 1962. He received a PhD in Agricultural and Forest Engineering from the University of Tsukuba, Japan, in 1999. He worked at the National Food Research Institute, Japan as a researcher from 1987. Currently, he is Head of the Advanced Food Technology Laboratory, National Food Research Institute, NARO, Japan. His current research interests include electrical processing, pasteurization, and sterilization of foods.

Mitsutoshi Nakajima

Mitsutoshi Nakajima was born in Kumamoto, Japan, in 1954. He received a PhD in Chemical Engineering from the University of Tokyo, Japan, in 1982. He worked on food engineering projects in Kyushu University (1980–1985), the National Food Research Institute (1985–2007), and University of Tsukuba (2007–present). Currently, he is the Director of Alliance for Research on North Africa (ARENA), and Professor of the Division of Appropriate Technology and Sciences for Sustainable Development, Graduate School of Life and Environmental Sciences at the University of Tsukuba, Japan. His current research interests include food engineering, food nanotechnology, and micro/nano-process systems.


Corresponding authors: Isao Kobayashi and Mitsutoshi Nakajima, Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan


Received: 2012-03-19

Accepted: 2012-04-05

Published Online: 2012-07-28

Published in Print: 2012-08-01


Citation Information: Green Processing and Synthesis, Volume 1, Issue 4, Pages 353–362, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2012-0023.

Export Citation

©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Nauman Khalid, Isao Kobayashi, Marcos A. Neves, Kunihiko Uemura, and Mitsutoshi Nakajima
Critical Reviews in Food Science and Nutrition, 2017, Page 1

Comments (0)

Please log in or register to comment.
Log in