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Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker / Tran, Nam Nghiep

Editorial Board: Akay, Galip / Arends, Isabel W.C.E. / Cann, Michael C. / Cheng, Yi / Cravotto, Giancarlo / Gruber-Wölfler, Heidrun / Kralisch, Dana / D. P. Nigam, Krishna / Saha, Basudeb / Serra, Christophe A. / Zhang, Wei

IMPACT FACTOR 2018: 1.128

CiteScore 2018: 0.97

SCImago Journal Rank (SJR) 2018: 0.263
Source Normalized Impact per Paper (SNIP) 2018: 0.366

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Volume 1, Issue 4


METTLER TOLEDO – Addressing key industry challenges from research to manufacturing

Fernandez Zoe
Published Online: 2012-08-25 | DOI: https://doi.org/10.1515/gps-2012-0040

METTLER TOLEDO solutions enable the development of a wide range of chemistries in the chemical and biopharmaceutical industries. Our enabling technologies and services help companies to bring products to market faster, at lower costs and with a higher quality.

Early phase development

Synthesis workstations and real-time analytics probes allow chemists to quickly develop new synthetic routes and then safely deliver grams to kilograms of materials. In addition, METTLER TOLEDO tools provide an early understanding of process scale-up issues, which enables scientists to eliminate non-viable candidates early in development, therefore saving money and development cost.

Process development

The combination of industry standard RC1e™ reaction calorimeter, Fourier Transform Infrared spectroscopy (FTIR) based in situ reaction analysis systems (ReactIR™) and particle characterization tools (FBRM™ and PVM™) enable the chemical, thermodynamic and particle characterization of processes. This increased process knowledge speeds the development of environmentally friendly, safe, robust batch and continuous processes. In addition, the enhanced quality and quantity of process knowledge enables engineers to quickly scale-up processes while eliminating scale-up failures.

Scale-up and manufacturing

Process Analytical Technology (PAT) tools ensure that the process is within boundary conditions, eliminating the risk of batch failures and ensuring the process delivers higher yields at a lower cost. Furthermore, our PAT systems allow customers to realize the benefits of Quality by Design (QbD) through the transfer of more robust, lower cost commercial processes to manufacturing.

PAT tools enable the successful transfer of processes from lab to plant.
Figure 1

PAT tools enable the successful transfer of processes from lab to plant.

Simple, powerful software

iC software integrates the entire experimental workflow, making it simple to visualize, interpret and report results. A unified approach supports lab to plant applications for spectroscopy, particle system characterization, precise reactor control and calorimetry. In each iC product, powerful algorithms and graphical representations are combined with a simple user interface, enabling scientists to gain deeper process understanding with less effort.

The complete solution to improve process R&D

ReactIR™ is a real-time, in situ mid-infrared based reaction analysis system designed to study reactions without disturbing chemistry. ReactIR™ is used to study reaction progression, giving specific information about reaction initiation, conversion, intermediates, and endpoint. The specificity of the information facilitates the elucidation of reaction mechanism and pathway.

The complete solution for improved process development.
Figure 2

The complete solution for improved process development.

The combination of RC1e with RTCal™ provides easy access to heat flow data in real time, without calibration. It enables chemists and engineers to quickly design economical, robust and safe processes, by obtaining heat flow data instantly, making adjustments to the actual chemistry in real time to optimize reaction and process parameters.

Gain deeper understanding of reaction processes.
Figure 3

Gain deeper understanding of reaction processes.

Innovative tools for chemical synthesis

The unique challenges that scientists in industry face, mean that they are looking to change the way they work. Even though chemical synthesis has remained largely unchanged for a long period of time, innovation has redefined the way organic syntheses are performed. Synthesis workstations are designed to specifically meet the requirements of synthetic chemists, making them more productive, and help them to perform better syntheses. EasyMax™ and OptiMax™ synthesis workstations provide a simple platform for product and process development functions, enabling scientists to meet the demands of today’s global market. These workstations replace traditional round bottom flasks and jacketed vessels with a versatile system that is easier and faster to use.

Measurement for real-time optimization

Focused Beam Reflectance Measurement (FBRM™) and Particle Vision and Measurement (PVM™) technologies provide precise inline measurements of particle dimension, shape and count, without sampling. Probe-based instruments measure particles and droplets in gas or liquid suspension at process concentration. FBRM™ and PVM™ supplies engineers and scientists with real-time information to speed development, maximize process performance, and optimize quality.

Innovative service solutions for reliable instrument performance

Researchers and engineers across industry and academia rely on METTLER TOLEDO instruments to provide critical information during investigations. To be successful, scientists need to be confident that the equipment works correctly, when it is needed, and that the results can be trusted. METTLER TOLEDO provides a range of service options to prevent instrument downtime, guarantee result quality and ensure regulatory compliance, while reducing the total cost of ownership. Our customized coverage minimizes unexpected costs, improves data collection reliability and reduces the total cost of ownership.

Enabling technologies bring products to market faster.
Figure 4

Enabling technologies bring products to market faster.


METTLER TOLEDO is a global manufacturer and marketer of precision instruments for use in laboratories, manufacturing and food retailing, with over 12,000 employees worldwide and sales of USD 2.309 billion (2011). METTLER-TOLEDO AutoChem, Inc. is a division of METTLER TOLEDO, with its headquarters in Columbia, MD, USA and manufacturing facilities in Redmond, WA, USA and Schwerzenbach, Switzerland. The Company provides the chemical and pharmaceutical industries with a variety of enabling technologies, including synthesis workstations, in situ FTIR reaction analysis systems and particle characterization tools which, combined with the iC Software Suite, enable scientists and engineers to make better decisions and complete projects faster.

About the article

Corresponding author: Zoe Fernandez, METTLER TOLEDO-Marketing, 7075 Samuel Morse Drive, Columbia, MD 21046, USA

Published Online: 2012-08-25

Published in Print: 2012-08-01

Citation Information: Green Processing and Synthesis, Volume 1, Issue 4, Pages 385–387, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2012-0040.

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©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

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