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Publicly Available Published by De Gruyter September 27, 2016

Hydrolysis of green nanocomposites of poly(lactic acid) (PLA), chitosan (CS) and polyethylene glycol (PEG) in acid solution

  • Nguyen Thi Thu Trang

    Nguyen Thi Thu Trang worked as a researcher at at the Department of Physicochemistry of Non-Metallic Materials, ITT, VAST. She received her MSc in Chemistry from the College of Science, Vietnam National University of Hanoi, in 2005. Nearly 30 of her articles and reports are related to conducting polymers and polymer nanocomposites and have been published in national and international journals or conference proceedings.

    , Nguyen Thuy Chinh

    Nguyen Thuy Chinh received her Bachelor’s degree in Chemistry from Hanoi National University of Education in 2009 and her MSc in Physical Chemistry from Hanoi National University of Education in 2011. Since 2009, she has been a researcher at the Department of Physicochemistry of Polymers and Non-Metallic Materials, ITT, VAST. Currently, she is working on her PhD thesis investigating drug delivery systems based on poly(lactic acid) and chitosan. Most of her work is related to the properties of nanomaterials and polymer nanocomposites.

    , Nguyen Vu Giang

    Nguyen Vu Giang received his Bachelor’s degree in Physical Engineering from Hanoi University of Education in 1994. His Master’s thesis dealt with the role of compatibilizers of polymer blend materials based on poly(methyl methacrylate) and polyethylene resins; he received his Master’s degree in 2001 from Hanoi University of Technology. During his PhD course (2002–2005 PhD obtained) at the Department of Polymer Science and Engineering, College of Engineering, Sunchon Natinal University, South Korea he worked on polymer composites using waste gypsum particles and applications. Currently, he is working in the fields of polymer nanocomposite and polymer blend materials, degradation and stability of polymers and rubbers, and green materials and their applications.

    , Dinh Thi Mai Thanh

    Dinh Thi Mai Thanh graduated from university in Vietnam in 1994 and received her PhD in Chemistry from the University of Paris 6, France, in 2003. She is a researcher at Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST). In 2010, she achieved an associate professorship and received the Prize of Unesco-L’Oreal Vietnam. She has published 80 papers in national and international journals. Her research fields are manufacturing dimensionally stable anodes based on titanium, treating toxic organics in wastewater and fabricating materials to apply in biomedicals such as Ti, TiN and HAP coatings by electrochemical methods.

    , Tran Dai Lam

    Tran Dai Lam received his Master’s degree in Solid State Chemistry from Belorussian State University (in the former USSR) in 1994, and his PhD in Physical Chemistry (Surface-Interface) from the University of Paris VII, Paris, France, in 2003. From 1998 to 2008, he was a research lecturer at Hanoi University of Technology. Since 2009, he has been an Associate Professor at IMS. His current research interests include nanofabrications, characterizations and applications of nanobiomaterials in drug delivery systems and biosensors.

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    , Le Van Thu

    Le Van Thu worked as a researcher at the Laboratory of Special Materials, Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security. He received his Bachelor’s degree in Material Chemistry from VNU University of Science in 2003, and his MSc in Physiochemical-Theoretical Chemistry from VNU University of Science in 2007. In 2012, he received his PhD in Physiochemical-Theoretical Chemistry from VietNam Academy of Science and Technology. Nearly 60 of his articles and reports are related to polymer composites and nanocomposites and have been published in national and international journals or conference proceedings. His present research concerns nanocomposite and polymer composite materials.

    , Ngo Dai Quang

    Ngo Dai Quang is Vice President of Vietnam National Chemical Group (Vinachem) which is directly under the Vietnamese Government. He is responsible for the field of scientific and technology research of Vinachem. He graduated with a major in Organic Chemistry from Hanoi National University of Education (HNUE) in 1982 and, in 1991, received his PhD in heterocyclic compounds that have high biological activities also from HNUE. He was a trainee in Korea in 2011 and received the title of Associate Professor in 2013. He has published more than 50 papers in Vietnam journals in the fields of organic synthesis and heterocyclic compounds.

    and Thai Hoang

    Thai Hoang is the head of ITT, VAST. He received his Bachelor’s degree in Chemical Engineering from Hanoi University of Technology in 1980, and his PhD in Polymer Chemistry from Vietnam National Center of Science and Technology in 1993. In 2012, he received the title of Professor in Chemistry. He carried out postdoctoral research on polymer blends, polymer composites and plastics technology in South Korea, UK and Japan. He has published 40 papers in international journals and more than 180 papers in national journals. He received the two Prizes of Vietnam Fund for Supporting Technological Creation in 2005 and 2015. His research fields are polymer blends, nanocomposites, biodegradable polymers, and bio-medical materials.

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Abstract

Green nanocomposites based on poly(lactic acid), chitosan, and polyethylene glycol (PLA/CS/PEG) were prepared by the solution method. The content of PEG was 2–10 wt.% compared with the weight of PLA. The characterization and morphology of the nanocomposites before and after hydrolysis in acid solution were determined by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry and scanning electron microscopy (SEM). The hydrolysis of PLA/CS/PEG nanocomposites in acid solution for different times was also investigated. The shift of C=O, CH3 groups in FTIR spectra of PLA/CS/PEG nanocomposites before and after hydrolysis was clearly observed. The SEM images of the nanocomposites indicate that PEG plays a role in improving the interaction between PLA and CS, resulting in limiting the permeability of acid solution into the structure of the nanocomposites in the presence of PEG. The obtained results after 28 days of testing in the acid solution show that the PLA/CS/PEG8 nanocomposite (containing 8 wt.% of PEG) had the lowest weight loss with the highest regression coefficient (R2=0.9614).

1 Introduction

Biodegradable polymers include natural polymers and synthetic polymers. The natural biodegradable polymers are starch, cellulose, chitin, chitosan (CS), gelatin, etc. The biodegradable synthetic polymers are polyester, i.e. poly(lactic acid) (PLA), poly glycolic acid, polyhydroxy alcanoat, polyamides, polyurethanes, polyvinyl acetate, polyacrylate, etc. [1]. Among the thermoplastic polymers, PLA is the most studied because of its advantages like some thermoplastic polymers (polyethylene, polypropylene, polyethylene terephthalate) as tensile strength, large modules and thermal stability [2]. In addition, PLA also has combustion resistance and anti-ultraviolet radiation stability [3], and especially is biodegradable.

CS is one of the natural resource polymers, which is present in the shells of insects and marine crustaceans, etc. CS and its derivatives have been used in many different areas [4], [5], [6]. In biomedical and pharmaceutical fields, CS is a good candidate for regenerating bone tissue and as a drug carrier [7], [8]. According to studies of Inez et al. [9], nasal and oral drugs are more easily transported after combination with CS. CS has high antibacterial activity, is safe for humans and has antimicrobial activity, depending on its molecular weights [10], [11].

The PLA/CS nanocomposite is expected to form new biomaterial exhibiting combinations of good properties of a component polymer that could not be obtained by individual polymers. The nanocomposite is promised to achieve better biodegradability, biocompatibility, elongation and antibacterial activity, improvement of water repellency of CS and increases in thermal stability of PLA [12], [13], [14], [15], [16]. Compatibilizers such as poly(ethylene oxide), poly(caprolactone) and poly(ethylene glycol) (PEG) have been used to enhance dispersibility and compatibility between CS and PLA. In this study, the characteristics of green nanocomposites of PLA/CS with and without PEG were studied. The hydrolysis of PLA/CS nanocomposites in hydrochloric 0.1 N acid solution was also evaluated and discussed.

2 Materials and methods

2.1 Materials

PLA was purchased from NatureWorks LLC (USA). CS and PEG were obtained from Sigma-Aldrich (USA). Chloroform and hydrochloric acid were of analytical reagent grade and used without further purification were provided by Guangdong Guanghua Chemical Factory Co. (China).

2.2 Preparation of PLA/CS nanocomposites

The solution method was applied for preparation of PLA/CS nanocomposites. PLA (1.5 wt.%) was dissolved in chloroform to form a fine solution. CS (at a concentration of 20 wt.% in comparison with PLA weight) was dissolved in acetic acid 1% solution (v/v) at room temperature under magnetic stirring. PEG as a compatibilizer was added to the PLA solution at different contents (0 wt.%, 2 wt.%, 4 wt.%, 6 wt.%, 8 wt.%, 10 wt.% PEG compared with PLA weight) that were abbreviated as PLA/CS; PLA/CS/PEG2, PLA/CS/PEG4, PLA/CS/PEG6, PLA/CS/PEG8, and PLA/CS/PEG10, respectively. The PLA/CS composites were obtained by solvent casting on Petri dishes, kept at room temperature for 24 h to evaporate the solvent and then dried in a vacuum oven at 40°C for 8 h.

2.3 Characterization

Fourier transform infrared (FTIR) spectra of PLA/CS/PEG nanocomposites were recorded on a Nicolet/Nexus 670 spectrometer (USA) at room temperature by 16 scans with 4 cm–1 resolution in the wave number range from 400 cm–1 to 4000 cm–1.

Field emission scanning electron microscopy (FE-SEM) of the PLA/CS/PEG nanocomposites coated with platinum was conducted using an S-4800 FE-SEM instrument (Hitachi, Japan).

Thermal properties were studied using a DSC-60 thermogravimetric analyzer (Shimadzu Co.) under argon atmosphere, from room temperature to 400°C, at a heating rate of 10°C/min.

Determination of weight loss of the samples in acid solution is based on the weight change after hydrolysis by the formula: m=([mb–ms]/mb).100%, in which m is loss weight of the sample (%), mb is initial sample weight (g), and ms is loss weight of the sample after hydrolysis (g).

3 Results and discussion

3.1 FTIR spectroscopy spectra of PLA/CS/PEG nanocomposites before and after hydrolysis in acid solution

Figure 1 shows FTIR spectroscopy spectra of the PLA/CS/PEG8 nanocomposite before and after 28 testing days in HCl 0.1 N acid solution. In the spectrum of the PLA/CS/PEG8 nanocomposite before testing, it is clear that the broad band at 3368 cm–1 corresponds to the -NH2 and -OH groups, the peak at 2944 cm–1 can be attributed to -CH stretching, the absorption band at 1754 cm–1 is due to C=O stretching, and the bending vibrations of the N-H are at 1559 cm–1. Additionally, the bending vibrations of the -CH3, -NH2groups are observed at 1381 cm–1and 1559 cm–1, respectively.

Figure 1: Fourier transform infrared (FTIR) spectroscopy of the poly(lactic acid) (PLA), chitosan (CS), and polyethylene glycol (PEG), (PLA/CS/PEG8, containing 8 wt.% of PEG) nanocomposite before and after testing 28 days in acid solution.
Figure 1:

Fourier transform infrared (FTIR) spectroscopy of the poly(lactic acid) (PLA), chitosan (CS), and polyethylene glycol (PEG), (PLA/CS/PEG8, containing 8 wt.% of PEG) nanocomposite before and after testing 28 days in acid solution.

The shift of wave number of the above groups can be observed for the PLA/CS/PEG8 nanocomposite after testing in comparison with the original sample. The wave number of the -OH group shifted from 3368 cm–1 to 3562 cm–1 with an expanded peak, and the NH2 group shifted from 1559 cm–1 to 1651 cm–1 with more weak intensity. Similarly, the C=O group vibration moves from 1755 cm–1to 1753 cm–1. This can be explained by the fact that PLA may be hydrolyzed in acid solution to break ester linkages. This leads to short segments of PLA, and LA oligomers were separated from the nanocomposite. The vibrations of the functional groups in the PLA/CS/PEG8 nanocomposite before and after 28 testing days in acid solution are shown in Table 1.

Table 1:

The characteristic absorption peaks of poly(lactic acid) (PLA), chitosan (CS), and polyethylene glycol (PEG), (PLA/CS/PEG8, containing 8 wt.% of PEG) nanocomposite before and after 28 testing days in acid solution (HCl 0.1 N).

SampleWavenumber (cm–1)
PLA/CS/PEG8 before testingPLA/CS/PEG8 after 28 testing days
νC=O17551753
νCH2878
ν-NH215591651
νC-O-C1086
δCH313811377
δ-CH2750
νOH33683562

3.2 Hydrolysis of PLA/CS/PEG nanocomposites in acid solution

The hydrolysis process of the PLA/CS/PEG nanocomposite in acid solution is mainly due to the hydrolysis of the PLA by direct influence of water and temperature. The hydrolysis mechanism of PLA in acid solution (HCl 0.1 N) is shown in Figure 2.

Figure 2: Hydrolysis mechanism of poly(lactic acid) (PLA) in acid solution (HCl 0.1 N).
Figure 2:

Hydrolysis mechanism of poly(lactic acid) (PLA) in acid solution (HCl 0.1 N).

Figure 3 presents weight loss of the PLA/CS/PEG nanocomposites vs. testing time in HCl 0.1 N acid. Obviously, the weight loss of PLA/CS/PEG nanocomposites with different contents of PEG is lower than that of the PLA/CS nanocomposite after 2 days, 5 days, 7 days, 14 days, and 28 days of hydrolysis in acid solution. This can be explained by the presence of PEG, which improves the dispersion and adhesion between CS and PLA phases and leads to decreased numbers of defects and holes in the PLA/CS/PEG nanocomposites compared with the PLA/CS nanocomposite. Thus, acid solution is more difficult to permeate into the PLA/CS/PEG nanocomposites and the hydrolysis of PLA in the nanocomposites is reduced. Among the tested samples, the PLA/CS nanocomposite containing 8 wt.% of PEG had weight loss lower than the others for the same hydrolysis time in acid solution.

Figure 3: Weight loss of poly(lactic acid), chitosan, and polyethylene glycol (PLA/CS/PEG) nanocomposites vs. testing time in HCl 0.1 N solution.
Figure 3:

Weight loss of poly(lactic acid), chitosan, and polyethylene glycol (PLA/CS/PEG) nanocomposites vs. testing time in HCl 0.1 N solution.

According to the data obtained from Figure 3, the regression equations reflecting the relationship between the weight loss of the samples and the testing time in acid solutions is presented in Table 2.

Table 2:

The regression equation between the weight loss (Y-%) of the samples and the testing time (X-days) in acid solution.

SampleRegression equationR2
PLA/CSY=–0.1179X2+5.0619X–0.17470.8462
PLA/CS/PEG2Y=13.464ln(X)–2.51850.8781
PLA/CS/PEG4Y=–0.1242X2+4.949X–1.25910.8926
PLA/CS/PEG6Y=–0.13X2+5.3223X–3.06840.913
PLA/CS/PEG8Y=6.8378ln(X)+2.55790.9614
PLA/CS/PEG10Y=–0.0579X2+2.4846X+2.5870.9013

CS, Chitosan; PEG, polyethylene glycol; PLA, poly(lactic acid).

It can be clearly seen from Table 2 that all the obtained equations are suitable quadratic curves, with regression coefficients ranging from 0.8462 to 0.9614. The highest regression coefficient from the regression equations, reflecting weight loss of PLA from PLA/CS/PEG8 nanocomposites hydrolyzed in acid solution, is 0.9614 (Figure 4) and the regression equation is Y=6.8378ln(X)+2.5579.

Figure 4: Weight loss of poly(lactic acid) (PLA), chitosan (CS), and polyethylene glycol (PEG), (PLA/CS/PEG8, containing 8 wt.% of PEG) nanocomposite vs. testing time in acid solution HCl 0.1 N.
Figure 4:

Weight loss of poly(lactic acid) (PLA), chitosan (CS), and polyethylene glycol (PEG), (PLA/CS/PEG8, containing 8 wt.% of PEG) nanocomposite vs. testing time in acid solution HCl 0.1 N.

3.3 Morphology of PLA/CS/PEG nanocomposites after hydrolysis in acid solution

Structure of PLA/CS/PEG nanocomposites has an important influence on their hydrolysis process in different solutions. The tight structure of PLA/CS/PEG has more little holes and defects, which results in limitation of permeability of acid solution into the structure of nanocomposites and PLA in nanocomposites is difficult to be hydrolyzed. It can be clearly seen from the SEM images that the surfaces of the PLA/CS, PLA/CS/PEG4 and PLA/CS/PEG8 nanocomposites were destroyed after 28 testing days in the acid solution (Figure 5).

Figure 5: Scanning electron microscopy (SEM) images of poly(lactic acid) (PLA)/chitosan (CS), PLA/CS/polyethylene glycol (PEG)4, PLA/CS/PEG8 before and after 28 testing days in the acid solution.
Figure 5:

Scanning electron microscopy (SEM) images of poly(lactic acid) (PLA)/chitosan (CS), PLA/CS/polyethylene glycol (PEG)4, PLA/CS/PEG8 before and after 28 testing days in the acid solution.

In acid solution, the PLA/CS nanocomposite was hydrolyzed faster than the PLA/CS/PEG nanocomposite, although PLA phases in both nanocomposites were hydrolyzed to form the dark holes, as seen in Figure 5. PEG enhances structural morphology of the PLA/CS nanocomposite by improving the compatibility and adhesion between PLA and CS phases [17]. After hydrolysis, the number and size of holes and defects of the PLA/CS nanocomposite (PLA/CS.HCl image) are higher than those of PLA/CS/PEG nanocomposites (PLA/CS/PEG4.HCl and PLA/CS/PEG8.HCl images). The image of the PLA/CS/PEG8 nanocomposite (8 wt.% of PEG) indicates the best compatibility between PLA and CS phases. This leads to a close and tight structure, which will limit the formation of holes and defects after hydrolysis of the samples in the acid solution. The morphologies of PLA/CS/PEG2, PLA/CS/PEG6 and PLA/CS/PEG10 nanocomposites are similar to the morphology of the PLA/CS/PEG4 nanocomposite.

3.4 Thermal behavior of PLA/CS/PEG nanocomposites after hydrolysis in acid solution

The differential scanning calorimetry thermograms of PLA/CS and PLA/CS/PEG nanocomposites before and after 28 testing days in HCl 0.1 N acid solution are displayed in Figure 6. Thermal behaviors such as glass transition temperature (Tg), melting temperature (Tm), enthalpy of melting, and degree of crystallinity of the nanocomposites are calculated and listed in Table 3.

Figure 6: Differential scanning calorimetry (DSC) thermograms of poly(lactic acid) (PLA)/chitosan (CS), PLA/CS/polyethylene glycol (PEG)4 and PLA/CS/PEG8 composites before and after 28 testing days in acid solution.
Figure 6:

Differential scanning calorimetry (DSC) thermograms of poly(lactic acid) (PLA)/chitosan (CS), PLA/CS/polyethylene glycol (PEG)4 and PLA/CS/PEG8 composites before and after 28 testing days in acid solution.

Table 3:

Differential scanning calorimetry (DSC) data and the degree of crystallinity (χc) of poly(lactic acid)/chitosan/polyethylene glycol (PLA/CS/PEG) nanocomposite before and after 28 testing days in acid solution.

SampleTg (°C)Tm(°C)∆Hm (J/g)χca (%)
Initial28 daysInitial28 daysInitial28 daysInitial28 days
PLA/CS59.761.915716210.618.6110.819.97
PLA/CS/PEG464.074.215017111.419.3612.220.79
PLA/CS/PEG869.673.615116716.435.5517.738.18
PLA/CS/PEG1066.263.615116515.826.9416.928.93

aχc(%)=∆Hmx100/∆Hm* where ∆Hm* is the heat of fusion for completely crystallized PLA (93.1 J/g). Tg, the glass transition temperature; Tm, the melting temperature; ∆Hc, the crystallization enthalpy; ∆Hm, the enthalpy of melting; χc, the degree of crystallinity. CS, Chitosan; PEG, polyethylene glycol; PLA, poly(lactic acid).

The Tg and Tm of PLA/CS/PEG nanocomposites after hydrolysis are higher than those of original samples. Tgand Tmof the PLA/CS nanocomposite with different contents of PEG are higher than those of the PLA/CS nanocomposite. This proves that using PEG, the PLA and CS phases are compatible because of hydrogen bond and dipole-dipole interactions [17]. The enthalpy of crystallization and melting of PLA/CS/PEG nanocomposites are higher than those of the PLA/CS nanocomposite. This is due to regular dispersion of CS into the PLA matrix leading to rearrangement of the crystal structure of PLA. Especially, the physical interactions formed between the PEG, PLA and CS make the degree of crystallinity of PLA/CS and PLA/CS/PEG nanocomposites significantly increase.

After 28 testing days in acid solution, the crystallinity of PLA/CS/PEG nanocomposites is higher than that of the nanocomposite before testing. This demonstrates that the amorphous parts of the PLA in the nanocomposites were hydrolyzed and the PLA crystal structure was rearranged. The degree of crystallinity of the PLA/CS/PEG8 nanocomposite after hydrolysis in acid solution is highest.

4 Conclusions

The FTIR spectra show the shift of characteristic peaks of functional groups in PLA/CS/PEG nanocomposites before and after testing in acid solution. The FE-SEM images of the nanocomposites indicate that the number of holes and defects in the structure of the PLA/CS/PEG nanocomposites after hydrolysis is lower than that of the PLA/CS nanocomposite. The weight loss of PLA/CS/PEG nanocomposites is lower than that of the PLA/CS nanocomposite. Among the tested samples, the weight loss of the PLA/CS/PEG8 nanocomposite vs. testing time is suitable to the regression equation Y=6.8378ln(X)+2.5579 with maximum regression coefficient (R2) of 0.9614.

About the authors

Nguyen Thi Thu Trang

Nguyen Thi Thu Trang worked as a researcher at at the Department of Physicochemistry of Non-Metallic Materials, ITT, VAST. She received her MSc in Chemistry from the College of Science, Vietnam National University of Hanoi, in 2005. Nearly 30 of her articles and reports are related to conducting polymers and polymer nanocomposites and have been published in national and international journals or conference proceedings.

Nguyen Thuy Chinh

Nguyen Thuy Chinh received her Bachelor’s degree in Chemistry from Hanoi National University of Education in 2009 and her MSc in Physical Chemistry from Hanoi National University of Education in 2011. Since 2009, she has been a researcher at the Department of Physicochemistry of Polymers and Non-Metallic Materials, ITT, VAST. Currently, she is working on her PhD thesis investigating drug delivery systems based on poly(lactic acid) and chitosan. Most of her work is related to the properties of nanomaterials and polymer nanocomposites.

Nguyen Vu Giang

Nguyen Vu Giang received his Bachelor’s degree in Physical Engineering from Hanoi University of Education in 1994. His Master’s thesis dealt with the role of compatibilizers of polymer blend materials based on poly(methyl methacrylate) and polyethylene resins; he received his Master’s degree in 2001 from Hanoi University of Technology. During his PhD course (2002–2005 PhD obtained) at the Department of Polymer Science and Engineering, College of Engineering, Sunchon Natinal University, South Korea he worked on polymer composites using waste gypsum particles and applications. Currently, he is working in the fields of polymer nanocomposite and polymer blend materials, degradation and stability of polymers and rubbers, and green materials and their applications.

Dinh Thi Mai Thanh

Dinh Thi Mai Thanh graduated from university in Vietnam in 1994 and received her PhD in Chemistry from the University of Paris 6, France, in 2003. She is a researcher at Institute for Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST). In 2010, she achieved an associate professorship and received the Prize of Unesco-L’Oreal Vietnam. She has published 80 papers in national and international journals. Her research fields are manufacturing dimensionally stable anodes based on titanium, treating toxic organics in wastewater and fabricating materials to apply in biomedicals such as Ti, TiN and HAP coatings by electrochemical methods.

Tran Dai Lam

Tran Dai Lam received his Master’s degree in Solid State Chemistry from Belorussian State University (in the former USSR) in 1994, and his PhD in Physical Chemistry (Surface-Interface) from the University of Paris VII, Paris, France, in 2003. From 1998 to 2008, he was a research lecturer at Hanoi University of Technology. Since 2009, he has been an Associate Professor at IMS. His current research interests include nanofabrications, characterizations and applications of nanobiomaterials in drug delivery systems and biosensors.

Le Van Thu

Le Van Thu worked as a researcher at the Laboratory of Special Materials, Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security. He received his Bachelor’s degree in Material Chemistry from VNU University of Science in 2003, and his MSc in Physiochemical-Theoretical Chemistry from VNU University of Science in 2007. In 2012, he received his PhD in Physiochemical-Theoretical Chemistry from VietNam Academy of Science and Technology. Nearly 60 of his articles and reports are related to polymer composites and nanocomposites and have been published in national and international journals or conference proceedings. His present research concerns nanocomposite and polymer composite materials.

Ngo Dai Quang

Ngo Dai Quang is Vice President of Vietnam National Chemical Group (Vinachem) which is directly under the Vietnamese Government. He is responsible for the field of scientific and technology research of Vinachem. He graduated with a major in Organic Chemistry from Hanoi National University of Education (HNUE) in 1982 and, in 1991, received his PhD in heterocyclic compounds that have high biological activities also from HNUE. He was a trainee in Korea in 2011 and received the title of Associate Professor in 2013. He has published more than 50 papers in Vietnam journals in the fields of organic synthesis and heterocyclic compounds.

Thai Hoang

Thai Hoang is the head of ITT, VAST. He received his Bachelor’s degree in Chemical Engineering from Hanoi University of Technology in 1980, and his PhD in Polymer Chemistry from Vietnam National Center of Science and Technology in 1993. In 2012, he received the title of Professor in Chemistry. He carried out postdoctoral research on polymer blends, polymer composites and plastics technology in South Korea, UK and Japan. He has published 40 papers in international journals and more than 180 papers in national journals. He received the two Prizes of Vietnam Fund for Supporting Technological Creation in 2005 and 2015. His research fields are polymer blends, nanocomposites, biodegradable polymers, and bio-medical materials.

Acknowledgments

The authors would like to thank the National Foundation for Science and Technology Development in Vietnam for financial support (subject code DT.NCCB-DHUD.2012-G/09, period of 2013–2016).

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Received: 2016-3-24
Accepted: 2016-6-27
Published Online: 2016-9-27
Published in Print: 2016-10-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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