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Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker

Editorial Board Member: Akay, Galip / Arends, Isabel / Cann, Michael C. / Cheng, Yi / Cravotto, Giancarlo / Gruber-Wölfler, Heidrun / Kralisch, Dana / D. P. Nigam, Krishna / Saha, Basudeb / Serra, Christophe A. / Zhang, Wei

6 Issues per year


IMPACT FACTOR 2016: 0.782

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Source Normalized Impact per Paper (SNIP) 2015: 0.402

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2191-9550
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Volume 2, Issue 2 (Apr 2013)

Issues

Assiut Microfluidics Laboratory

Mohamed Omar Abdelgawad
Published Online: 2013-04-06 | DOI: https://doi.org/10.1515/gps-2013-0018

Assiut University

Assiut University is a comprehensive university in southern Egypt composed of 16 faculties and two institutes. Founded in 1949, Assiut University is the fourth oldest university in Egypt. The university offers 200 undergraduate and graduate degree programs to >70,000 undergraduate students and 14,000 graduate students. The university employs about 2100 faculty members.

Assiut Microfluidics Lab

Assiut Microfluidics Lab was established by Dr. Mohamed Abdelgawad in September 2010 to be the first microfluidics laboratory in Egypt. The laboratory focuses on three main research tracks:

  1. Understanding the fundamentals of liquid manipulation on the microscale to enable a more efficient design of microfluidics and lab-on-chip systems.

  2. Exploring new biological applications that can benefit from the inherent advantages in microfluidics to advance health care and biomedical research in Egypt.

  3. Developing new low-cost techniques to fabricate microfluidics chips with the limited facilities of typical laboratories in developing countries.

Key person

Dr. Mohamed Omar Abdelgawad is the director of Assiut Microfluidics Lab. He received his PhD in Mechanical Engineering from the University of Toronto in 2009. His PhD research focused on the use of digital microfluidics as a tool to automate sample processing on lab-on-chip devices. Some of Dr. Abdelgawad’s achievements during his PhD include developing the first hybrid digital-channel microfluidics platform [1], three low-cost rapid prototyping techniques to produce microfluidics chips [2–4], and a digital microfluidics chip to measure estrogen levels in breast tissue [5]. Before joining Assiut University, Dr. Abdelgawad worked as a postdoctoral fellow at the Department of Surgical Oncology at Princess Margaret Hospital in Toronto, where he was part of a team developing a microfluidics chip to measure the mechanical stiffness of bladder cells exfoliated in urine as a mechanical biomarker for cancer detection. Dr. Abdelgawad’s area of expertise includes digital microfluidics, rapid prototyping techniques, dielectrophoretic manipulation of particles, and mechanical characterization of biological cells.

Current research projects

Building a microfluidic chip to gauge the mechanical properties of biological cells

Mechanical properties of biological cells bear a significant relation with the state of health of the cell. Some diseases increase the mechanical stiffness of cells as in the case of malaria with red blood cells [6], whereas others decrease cell stiffness as in many reported cancer types [7]. The aim of this project is to build a chip that measures the mechanical stiffness of different cells to use it as a biomarker for different diseases.

Modeling droplet actuation in digital microfluidics

Electrodynamic forces induced on droplets in digital microfluidics are dependent on many factors, such as electrical properties of the liquid being manipulated, electrode shape, actuation frequency, and device geometrical parameters [8]. By simulating droplet actuation numerically, the effect of liquid properties and actuation frequency on electrodynamic forces generated on droplets and on droplet motion will be understood, which should enable more efficient device designs based on the intended application.

Studying contact angle saturation in electrowetting

When the potential of a sessile droplet sitting on a hydrophobic surface is biased relative to the electrode beneath the droplet, the electrodynamic forces generated on the droplet spread it on the surface, thus reducing its contact angle. This electrically induced wetting, called electrowetting, has extensive applications in optics, such as variable focal length lenses [9] and flexible displays [10]. The aim of this project is to use energy modeling to find an explanation for the contact angle saturation phenomenon in electrowetting, where the droplet contact angle ceases to decrease at a certain voltage contrary to the predictions of the physics of electrowetting.

Low-cost digital microfluidics for exploratory research and educational purposes

In this project, we target spreading digital microfluidics technology into the academic community for exploratory research and educational purposes, by integrating rapidly prototyped devices [3, 4] with a portable and inexpensive setup to generate and control the high potentials required for droplet manipulation. We believe such a combination will encourage researchers with non-engineering backgrounds, in Egypt and throughout the world, to test digital microfluidics as a useful tool in their respective fields. Such low-cost and accessible adaptation should promote the technology and generate novel applications.

www.assiutmicrofluidics.com

References

  • [1]

    Abdelgawad M, Watson MWL, Wheeler AR. Lab Chip 2009, 9, 1046–1051.PubMedGoogle Scholar

  • [2]

    Abdelgawad M, Watson MWL, Young EKW, Mudrik J, Ungrin MD, Wheeler AR. Lab Chip 2008, 8, 1379–1385.PubMedGoogle Scholar

  • [3]

    Abdelgawad M, Wheeler AR. Adv. Mater. 2007, 19, 133–137.Google Scholar

  • [4]

    Abdelgawad M, Wheeler AR. Microfluid. Nanofluidics 2008, 4, 349–355.Google Scholar

  • [5]

    Mousa NA, Jebrail MJ, Yang H, Abdelgawad M, Metalnikov P, Chen J, Wheeler AR, Casper RF. Sci. Transl. Med. 2009, 1, 1ra2.Google Scholar

  • [6]

    Suresh S, Spatz J, Mills JP, Micoulet A, Dao M, Lim CT, Beil M, SeufferleinT. Acta Biomater. 2005, 1, 15–30.PubMedGoogle Scholar

  • [7]

    Cross SE, Jin YS, Rao J, Gimzewski JK. Nat. Nanotechnol. 2007, 2, 780–783.PubMedGoogle Scholar

  • [8]

    Abdelgawad M, Park P, Wheeler AR. J. Appl. Phys. 2009, 105, 094506.Google Scholar

  • [9]

    Berge B, Peseux J. Eur. Phys. J. E Soft Matter 2000, 3, 159–163.Google Scholar

  • [10]

    Hayes RA, Feenstra BJ. Nature 2003, 425, 383–385.Google Scholar

About the article

Corresponding author: Mohamed Omar Abdelgawad, Mechanical Engineering Department, Assiut University, University Street, Assiut 71515, Egypt


Published Online: 2013-04-06

Published in Print: 2013-04-01


Citation Information: Green Processing and Synthesis, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2013-0018.

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©2013 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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