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Green Processing and Synthesis

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Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Dong Quy Hoang1 / Tuong Vi Tran2 / Ngoc Quyen Tran2 / Cuu Khoa Nguyen2 / Thi Hiep Nguyen3 / Minh Dung Truong4 / Dai Lam Tran5 / Le Van Thu6 / 2

1Faculty of Materials Science, University of Science, Vietnam National University, Ho Chi Minh City 70000, Viet Nam

2Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet Nam

3Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 70000, Viet Nam

4Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea (Republic of)

5Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam

6Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security, 44 Yet Kieu, Hoan Kiem, Hanoi, Viet Nam

Citation Information: Green Processing and Synthesis. Volume 5, Issue 5, Pages 459–466, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2016-0093, September 2016

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In this report, magnetic Fe3O4 nanoparticles were functionalized with chitosan-grafted-poly(ethylene glycol) methyl ether (CTS-mPEG) for paclitaxel (PTX) delivery. The Fe3O4 nanoparticles were prepared via the chemical coprecipitation method and then coated with CTS-mPEG (Fe3O4@CTS-mPEG) by a simple method. The formation of Fe3O4@CTS-mPEG was characterized by several methods including proton nuclear magnetic resonance spectroscopy, Fourier transform infrared, and X-ray diffraction. Furthermore, the superparamagnetic properties of Fe3O4@CTS-mPEG were demonstrated by a vibrating sample magnetometer; the saturation magnetization reached 23 emu g–1. The sizes and morphologies of Fe3O4 and Fe3O4@CTS-mPEG nanoparticles were determined by transmission electron microscopy. The result indicated that Fe3O4@CTS-mPEGs were nearly spherical in shape with an average diameter of 20 nm, compared with the 12-nm Fe3O4 particles. Especially, PTX was effectively loaded into the coated nanoparticles, 86.9±3.4% for drug loading efficiency, and slowly released up to 120 h. These results suggest the potential applications of Fe3O4@CTS-mPEG in the development of stable drug delivery systems for cancer treatment.

Keywords: chitosan; controlled drug delivery; paclitaxel; poly(ethylene glycol); superparamagnetic iron oxide

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