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Green Processing and Synthesis

Editor-in-Chief: Hessel, Volker

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Volume 5, Issue 5 (Oct 2016)

Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

Dong Quy Hoang
  • Faculty of Materials Science, University of Science, Vietnam National University, Ho Chi Minh City 70000, Viet Nam
/ Tuong Vi Tran
  • Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet Nam
/ Ngoc Quyen Tran
  • Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet Nam
/ Cuu Khoa Nguyen
  • Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet Nam
/ Thi Hiep Nguyen
  • Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 70000, Viet Nam
/ Minh Dung Truong
  • Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea (Republic of)
/ Dai Lam Tran
  • Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
/ Le Van Thu
  • Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security, 44 Yet Kieu, Hoan Kiem, Hanoi, Viet Nam
/ Dai Hai Nguyen
  • Corresponding author
  • Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 70000, Viet Nam
  • Email:
Published Online: 2016-09-01 | DOI: https://doi.org/10.1515/gps-2016-0093

Abstract

In this report, magnetic Fe3O4 nanoparticles were functionalized with chitosan-grafted-poly(ethylene glycol) methyl ether (CTS-mPEG) for paclitaxel (PTX) delivery. The Fe3O4 nanoparticles were prepared via the chemical coprecipitation method and then coated with CTS-mPEG (Fe3O4@CTS-mPEG) by a simple method. The formation of Fe3O4@CTS-mPEG was characterized by several methods including proton nuclear magnetic resonance spectroscopy, Fourier transform infrared, and X-ray diffraction. Furthermore, the superparamagnetic properties of Fe3O4@CTS-mPEG were demonstrated by a vibrating sample magnetometer; the saturation magnetization reached 23 emu g–1. The sizes and morphologies of Fe3O4 and Fe3O4@CTS-mPEG nanoparticles were determined by transmission electron microscopy. The result indicated that Fe3O4@CTS-mPEGs were nearly spherical in shape with an average diameter of 20 nm, compared with the 12-nm Fe3O4 particles. Especially, PTX was effectively loaded into the coated nanoparticles, 86.9±3.4% for drug loading efficiency, and slowly released up to 120 h. These results suggest the potential applications of Fe3O4@CTS-mPEG in the development of stable drug delivery systems for cancer treatment.

Keywords: chitosan; controlled drug delivery; paclitaxel; poly(ethylene glycol); superparamagnetic iron oxide

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About the article

Dong Quy Hoang

Dong Quy Hoang received her PhD in polymer science and engineering from Sungkyunkwan University, Korea. She is mainly engaged in the study of the synthesis of polymers, biopolymers, composites-biocomposites, and flame-retardant polymers.

Tuong Vi Tran

Tuong Vi Tran received her Bachelor of Biotechnology degree from Ho Chi Minh City International University, Vietnam, in 2015. She now works as a research assistant with Dr. Dai Hai Nguyen at the Institute of Applied Materials Science-Vietnam Academy of Science and Technology. Her major research is related to synthesis and characterization of nanomaterials such as chitosan nanogels and gelatin hydrogels as drug delivery systems for cancer therapy.

Ngoc Quyen Tran

Ngoc Quyen Tran was born in 1979. He received a PhD degree in the Republic of Korea in 2011. He is currently a researcher at the Institute of Applied Materials Science-Vietnam Academy of Science and Technology. He is also an invited lecturer at TraVinh University and Lac Hong University. His teaching and studying areas are biochemistry and biomaterials for biomedical applications.

Cuu Khoa Nguyen

Cuu Khoa Nguyen was born in 1960. He received a PhD degree in Russia in 1997. He returned to Vietnam and worked at the Institute of Applied Materials Science-Vietnam Academy of Science and Technology. He was appointed associate professor in 2010. His teaching and study areas are materials and biomaterials for practical applications.

Thi Hiep Nguyen

Thi Hiep Nguyen has a PhD in medical science and 10 years of experience in tissue engineering and regenerative medicine. The main focus of Hiep’s research is regeneration of skin and bone, and her work has covered a full range from fabricating biomaterials to in vitro and in vivo studies. Hiep attended Soonchunhyang University in 2012, and moved to work at the International University (IU), Vietnam National University-Ho Chi Minh City (VNU-HCM) until present. She currently has a senior lecturer position at IU, leads the tissue engineering and regenerative group, and manages her own laboratory. Hiep is running two projects funded by Vietnam National University and Office of Naval Research Global (ONRG). She has published 20 articles in international journals and 7 articles in domestic journals. Hiep has attended more than 40 conferences thus far.

Minh Dung Truong

Minh Dung Truong was born in 1985. He is a PhD candidate at the Department of Molecular Science and Technology in Ajou University, Korea. His major research area is stem cell application in tissue engineering.

Dai Lam Tran

Dai Lam Tran graduated from Belorussian State University (in the former USSR) with a master’s degree in solid state chemistry in 1994. Then, he received his PhD in physical chemistry (surface-interface) from the University of Paris VII, Paris, France, in 2003. He was a lecturer at Hanoi University of Technology from 1998 to 2008. He has been an Associate Professor at IMS since 2009. His research focus is on nanofabrications, characterizations, and applications of nanobiomaterials in drug delivery systems and biosensors.

Le Van Thu

Le Van Thu worked as a researcher at the Laboratory of Special Materials, Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security. He received his bachelor’s degree in material chemistry from VNU University of Science in 2003, and his master of science in physiochemical-theoretical chemistry from VNU University of Science in 2007. In 2012, he received his PhD in physiochemical-theoretical chemistry from Vietnam Academy of Science and Technology. Nearly 60 of his articles and reports related to polymer composite and nanocomposites have been published in national journals, international journals, proceedings of national and international scientific conferences, and workshops. His present research concerns nanocomposite and polymer composite materials.

Dai Hai Nguyen

Dai Hai Nguyen was born in 1984. He received a PhD degree from Ajou University-Republic of Korea in 2013. Currently, he works as a researcher at the Institute of Applied Materials Science-Vietnam Academy of Science and Technology. He is also an invited lecturer in TraVinh University and Ho Chi Minh City University of Natural Sciences.


Received: 2016-05-17

Accepted: 2016-07-26

Published Online: 2016-09-01

Published in Print: 2016-10-01


Citation Information: Green Processing and Synthesis, ISSN (Online) 2191-9550, ISSN (Print) 2191-9542, DOI: https://doi.org/10.1515/gps-2016-0093. Export Citation

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