Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Green

a systemic approach to energy

Editor-in-Chief: Schlögl, Robert

Managing Editor: Tiedtke, Marion

Editorial Board: Luther, Joachim / Meng, Qingbo / Hüttl, Reinhard F. / Koumoto, Kunihito / Gasteiger, Hubert


SCImago Journal Rank (SJR) 2018: 0.248
Source Normalized Impact per Paper (SNIP) 2018: 0.421

More options …

From Pathways to Genomes and Beyond: The Metabolic Engineering Toolbox and Its Place in Biofuels Production

Leqian Liu
  • Department of Chemical Engineering, The University of Texas at Austin, 1 University Station, C0400, Austin, Texas 78712, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ben Reed
  • Department of Chemical Engineering, The University of Texas at Austin, 1 University Station, C0400, Austin, Texas 78712, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hal Alper
  • Corresponding author
  • Department of Chemical Engineering, The University of Texas at Austin, 1 University Station, C0400, Austin, Texas 78712, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-03-10 | DOI: https://doi.org/10.1515/green.2011.006

Abstract

Concerns about the availability of petroleum-derived fuels and chemicals have led to the exploration of metabolically engineered organisms as novel hosts for biofuels and chemicals production. However, the complexity inherent in metabolic and regulatory networks makes this undertaking a complex task. To address these limitations, metabolic engineering has adapted a wide-variety of tools for altering phenotypes. In this review, we will highlight traditional and recent metabolic engineering tools for optimizing cells including pathway-based, global, and genomics enabled approaches. Specifically, we describe these tools as well as provide demonstrations of their effectiveness in optimizing biofuels production. However, each of these tools provides stepping stones towards the grand goal of biofuels production. Thus, developing methods for largescale cellular optimization and integrative approaches are invaluable for further cell optimization. This review highlights the challenges that still must be met to accomplish this goal.

Keywords.: Metabolic engineering; biofuels; systems biology; synthetic biology; mutagenesis

About the article

Corresponding author: Hal Alper, E-mail: .


Received: 2010-10-11

Accepted: 2011-01-06

Published Online: 2011-03-10

Published in Print: 2011-03-01


Citation Information: Green, Volume 1, Issue 1, Pages 81–95, ISSN (Online) 1869-8778, ISSN (Print) 1869-876X, DOI: https://doi.org/10.1515/green.2011.006.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
John Blazeck, Leqian Liu, Heidi Redden, and Hal Alper
Applied and Environmental Microbiology, 2011, Volume 77, Number 22, Page 7905
[2]
John Blazeck, Rishi Garg, Ben Reed, and Hal S. Alper
Biotechnology and Bioengineering, 2012, Volume 109, Number 11, Page 2884

Comments (0)

Please log in or register to comment.
Log in