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Heterocyclic Communications

Editor-in-Chief: Strekowski, Lucjan

Ed. by Baumstark, Alfons L. / Saczewski, Jaroslaw / Stephens, Chad / Yamada, Hidetoshi

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Volume 21, Issue 1

Issues

Improved synthesis of 6-[(ethylthio)methyl]-1H-indazole

Agnès M. Sirven
  • CEMES-CNRS, BP 94347, 29 rue J. Marvig, F-31055 Toulouse, France
  • Université de Toulouse, UPS, 29 rue J. Marvig, F-31055 Toulouse, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Roman Stefak / Gwénaël Rapenne
  • Corresponding author
  • CEMES-CNRS, BP 94347, 29 rue J. Marvig, F-31055 Toulouse, France
  • Université de Toulouse, UPS, 29 rue J. Marvig, F-31055 Toulouse, France
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-01-10 | DOI: https://doi.org/10.1515/hc-2014-0180

Abstract

In the improved synthesis of 6-[(ethylthio)methyl]-1H-indazole (5), the mesylate intermediate is replaced by the bromide derivative, which increases the overall yield (six steps) by a factor of 3.

This article offers supplementary material which is provided at the end of the article.

Keywords: bromide; indazoles; mesylate; protecting groups

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About the article

Corresponding author: Gwénaël Rapenne, CEMES-CNRS, BP 94347, 29 rue J. Marvig, F-31055 Toulouse, France, e-mail: ; and Université de Toulouse, UPS, 29 rue J. Marvig, F-31055 Toulouse, France


Received: 2014-10-28

Accepted: 2014-11-25

Published Online: 2015-01-10

Published in Print: 2015-02-01


Citation Information: Heterocyclic Communications, Volume 21, Issue 1, Pages 5–8, ISSN (Online) 2191-0197, ISSN (Print) 0793-0283, DOI: https://doi.org/10.1515/hc-2014-0180.

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