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Heterocyclic Communications

Editor-in-Chief: Strekowski, Lucjan

Ed. by Baumstark, Alfons L. / Saczewski, Jaroslaw / Stephens, Chad / Yamada, Hidetoshi

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2191-0197
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Volume 24, Issue 4

Issues

Synthesis of benzofuro[3,2-b]furo[2,3-d]pyridin-4(5H)-ones, derivatives of a novel heterocyclic system

Marta S. Yahodkina-Yakovenko
  • Corresponding author
  • Institute of Organic Chemistry, National Academy of Science of ukraine, 5 Murmanska str., Kyiv 02660, Ukraine
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/ Andriy V. Bol’but
  • Corresponding author
  • Institute of Organic Chemistry, National Academy of Science of ukraine, 5 Murmanska str., Kyiv 02660, Ukraine
  • RPA “Enamine”, 78 Chervonotkatska str., Kyiv 02660, Ukraine
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/ Mykhailo V. Vovk
  • Institute of Organic Chemistry, National Academy of Science of ukraine, 5 Murmanska str., Kyiv 02660, Ukraine
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Published Online: 2018-07-19 | DOI: https://doi.org/10.1515/hc-2017-0143

Abstract

Methyl 2-[(cyanophenoxy)methyl]-3-furoates obtained from methyl 2-(chloromethyl)-3-furoate and salicylonitriles undergo tandem cyclization in the presence of excess t-BuOK in N,N-dimethylformamide (DMF) solution at 65°C to give substituted benzofuro[3,2-b]furo[2,3-d]pyridin-4(5H)-ones, derivatives of a novel heterocyclic system.

Keywords: alkylation; benzofuro[3,2-b]furo[2,3-d]pyridines; methyl 2-(chloromethyl)-3-furoates; salicylonitriles; tandem cyclization

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About the article

Received: 2017-08-01

Accepted: 2018-04-02

Published Online: 2018-07-19

Published in Print: 2018-08-28


Citation Information: Heterocyclic Communications, Volume 24, Issue 4, Pages 177–181, ISSN (Online) 2191-0197, ISSN (Print) 0793-0283, DOI: https://doi.org/10.1515/hc-2017-0143.

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