Jump to ContentJump to Main Navigation
Show Summary Details

Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board Member: Groner, Bernd / Hubalek, Michael / Saad, Farid / Schally, Andrew V. / Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Kloet, Ronald / Nicola, Alejandro F. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Flores-Morales, Amilcar / Garcia-Segura, Luis M. / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Hilakivi-Clarke, Leena / Hampl, Richard / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Sanchez, Edwin R. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi / Feve, Bruno / Foster, Michelle T.

4 Issues per year


SCImago Journal Rank (SJR) 2015: 0.432
Source Normalized Impact per Paper (SNIP) 2015: 0.334
Impact per Publication (IPP) 2015: 1.034

Online
ISSN
1868-1891
See all formats and pricing
Volume 1, Issue 2 (Jan 2010)

Issues

Estrogen-induced breast cancer is the result of disruption of asymmetric cell division of the stem cell

Jose Russo
  • Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
/ Kara Snider
  • Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
/ Julia S. Pereira
  • Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
/ Irma H. Russo
  • Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA, USA
Published Online: 2009-09-17 | DOI: https://doi.org/10.1515/hmbci.2010.011

Abstract

Stem cells have the unique potential to divide asymmetrically to generate daughters with distinct fates, one which remains a stem cell and the other which turns into a cell committed to differentiation. By dividing asymmetrically, stem cells maintain the stem cell pool and simultaneously generate committed cells that reconstitute the organ, for example, to prepare the breast for a new pregnancy after involution from a previous pregnancy and lactation process. In addition to the in vivo models of mammary morphogenesis, there are in vitro systems that make the ductulogenic pattern of breast epithelia growth more amenable to study in critically determined conditions. The human breast epithelial cells MCF-10F formed tubules when grown in type I collagen and we demonstrated that treatment of these cells with 17β-estradiol (E2) induces phenotypical changes indicative of neoplastic transformation. The transformation of MCF-10F by E2 is associated with impaired ductal morphogenesis caused by an alteration of the stem cells unique potential to divide asymmetrically, inducing formation of solid masses and mimicking intraductal carcinoma that progresses into an invasive and tumorigenic phenotype. In the present work, we present evidence for the mechanism of cell asymmetry which leads to normal ductulogenesis and show how the normal stem cell is transformed into a cancer stem cell by altering this process. Furthermore, we demonstrate that the carcinogenic agent, in this case E2, induces a defect in the asymmetric cell division program of the normal mammary stem cell.

Keywords: asymmetric cell division; breast cancer; carcinogenesis; estrogen; stem cell

About the article

Corresponding author: Jose Russo, MD, Professor, Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA Phone: +1-215-728-4782, Fax: +1-215-728-2180,


Received: 2009-07-15

Accepted: 2009-08-19

Published Online: 2009-09-17

Published in Print: 2010-01-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/hmbci.2010.011. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Amal M. Moustafa and Vivian Boshra
Journal of Molecular Histology, 2011, Volume 42, Number 3, Page 217

Comments (0)

Please log in or register to comment.
Log in