Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi

4 Issues per year

CiteScore 2016: 2.15

SCImago Journal Rank (SJR) 2015: 0.432
Source Normalized Impact per Paper (SNIP) 2015: 0.334

See all formats and pricing
More options …
Volume 2, Issue 1


Recent advances on the action of estrogens and progestogens in normal and pathological human endometrium

Jorge R. Pasqualini / Gérard S. Chetrite
  • Assistance Publique-Hôpitaux de Paris, CHU Bicêtre, INSERM U693, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-05-18 | DOI: https://doi.org/10.1515/hmbci.2010.027


Hormonal control in the development of the normal endometrium is of the utmost importance. It is well established that the two main hormones involved in this process are estradiol and progesterone, which are also implicated in the pathological conditions concerning endometriosis and endometrial carcinoma. There are two types of endometrial carcinoma: type I which represents 80%–90% is hormone-dependent, whereas the remainder is type II and is hormone-independent. The endometrial tissue contains all the enzymatic systems in the formation and transformation of the various hormones, including aromatases, sulfatases, sulfotransferases, hydroxysteroid dehydrogenases, hydroxylases, and glucuronidases. It is interesting to note that increased sulfatase activity is correlated with severity of endometriosis. An increased sulfatase/sulfotransferase ratio represents a poor prognosis in patients with endometrial carcinoma. Treatment with hormone replacement therapy (estrogens+progestogens), as well as with tibolone, is most effective in protecting this tissue by climacteric alterations, owing to the significant decrease of ovarian hormones. In conclusion, enzymatic control can open appealing perspectives to protect this organ from possible pathological alterations.

Keywords: cancer; endometriosis; endometrium; estrogens; progesterone

About the article

Corresponding author: Prof. J.R. Pasqualini, Hormones and Cancer Research Unit, 45 Boulevard Brune, 75014 Paris, France Phone: +33-1-4542-4121, Fax: +33-1-4542-6121,

Received: 2009-11-19

Accepted: 2010-04-07

Published Online: 2010-05-18

Published in Print: 2010-08-01

Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 2, Issue 1, Pages 155–175, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/hmbci.2010.027.

Export Citation

©2010 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Gérard S. Chetrite, Joaquin Cortes-Prieto, and Jorge R. Pasqualini
Hormone Molecular Biology and Clinical Investigation, 2011, Volume 8, Number 3
Jorge R. Pasqualini and Gérard S. Chetrite
Hormone Molecular Biology and Clinical Investigation, 2010, Volume 3, Number 3

Comments (0)

Please log in or register to comment.
Log in