Jump to ContentJump to Main Navigation
Show Summary Details

Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board Member: Groner, Bernd / Hubalek, Michael / Saad, Farid / Schally, Andrew V. / Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Kloet, Ronald / Nicola, Alejandro F. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Flores-Morales, Amilcar / Garcia-Segura, Luis M. / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Hilakivi-Clarke, Leena / Hampl, Richard / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Sanchez, Edwin R. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi / Feve, Bruno / Foster, Michelle T.

4 Issues per year


SCImago Journal Rank (SJR) 2015: 0.432
Source Normalized Impact per Paper (SNIP) 2015: 0.334
Impact per Publication (IPP) 2015: 1.034

Online
ISSN
1868-1891
See all formats and pricing
Volume 4, Issue 1 (Dec 2010)

Issues

The relationship between testosterone deficiency and frailty in elderly men

Farid Saad
  • Bayer-Schering Pharma, Scientific Affairs, Men's Health Care, Berlin, Germany
  • Gulf Medical University, School of Medicine, Ajman, United Arab Emirates
  • Email:
Published Online: 2011-01-21 | DOI: https://doi.org/10.1515/HMBCI.2010.060

Abstract

The vulnerable health status usually preceding the onset of overt disability is often referred to as frailty. A stringent definition is elusive but it can be viewed as a physiological syndrome, characterized by decreased reserve and diminished resistance to stressors, resulting from a cumulative decline across multiple physiological systems and causing vulnerability to adverse outcomes. Elements of frailty are related to the neurological system, metabolism, joints, bones, and muscles. Sarcopenia seems to be the major determinant of frailty. Several components of the frailty syndrome are related to loss of physiological actions of testosterone (T). T and/or its aromatized metabolite, estradiol, are necessary for maintenance of bone mineral density. Furthermore, T stimulates erythrocyte formation. T has a profound effect on body composition. Androgens promote differentiation of mesenchymal pluripotent cells into the myogenic lineage and inhibit differentiation into the adipogenic lineage. Skeletal muscles of older men are as responsive to the anabolic effects of T as of younger men. Thus, although frailty is obviously a complex syndrome, some elements are androgen-associated and these can improve in men with subnormal T levels when treated with T. Evidence suggests that T treatment in frail elderly men with low T improves body composition, quality of life, and physical function, including increased axial bone mineral density and body composition. The data available to date strongly suggest a relationship between T-deficiency and frailty and warrant further basic and clinical investigations to extend these observations to the management of elderly men with frailty.

Keywords: bone mineral density; frailty; sarcopenia; sarcopenic obesity; testosterone; testosterone deficiency

About the article

Corresponding author: Farid Saad, Bayer-Schering Pharma, Scientific Affairs, Men's Health Care, Berlin, Germany Phone: +49-30-46815057, Fax: +49-30-46895057


Received: 2010-10-22

Accepted: 2010-10-22

Published Online: 2011-01-21

Published in Print: 2010-12-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/HMBCI.2010.060. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Abdulmaged M. Traish, Bassima Abdallah, and George Yu
Hormone Molecular Biology and Clinical Investigation, 2011, Volume 8, Number 1

Comments (0)

Please log in or register to comment.
Log in