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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi


CiteScore 2018: 2.43

SCImago Journal Rank (SJR) 2018: 0.947
Source Normalized Impact per Paper (SNIP) 2018: 0.837

Online
ISSN
1868-1891
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Volume 5, Issue 3

Issues

Sex steroids in uterine endometrial cancers

Jiro Fujimoto
  • Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu, Japan
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  • Other articles by this author:
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/ Eriko Sato
  • Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-03-04 | DOI: https://doi.org/10.1515/HMBCI.2010.049

Abstract

Some uterine endometrial cancers conserve estrogen dependency in advancement. However, the concept of advancement in tumor is complicated, because it involves simple growth in primary tumor and secondary spreading. The expression manner of estrogen receptor alpha exon 5 splicing variant, ER beta, progesterone receptor-A (N-terminus deletion mutant) is associated with metastatic potential in uterine endometrial cancers. Increased estrogen-related receptor alpha expression is related to tumor advancement with the loss of estrogen dependency. Steroid receptor coactivator-3 contributes to tumor progression and can be used as a treatment target for advanced uterine endometrial cancers. Estrogen responsive oncogenes, c-jun and c-Ha-ras, are not modi-fied by progestin in uterine endometrial cancer cells and are considered to be an instinct phenotype as such cancers. By contrast, metastatic potential of estrogen-dependent uterine endometrial cancers can be partially controlled by progestin via metastasis-related genes, E-cadherin/catenins, plasminogen activator inhibitor-1, vascular endothelial growth factor. Thus, sex steroids related phenomena are impress-ive in the advancement of uterine endometrial cancers.

Keywords: c-Ha-ras; c-jun; E-cadherin/catenins; ER beta (ERb); estrogen receptor alpha exon 5 splicing variant (ERaE5SV); estrogen-related receptor alpha (ERRa); plasminogen activator inhibitor (PAI)-1; progesterone receptor (PR)-A; steroid receptor coactivator (SRC)-3; uterine endometrial cancer; vascular endothelial growth factor (VEGF)

About the article

Corresponding author: Jiro Fujimoto, MD, PhD, Professor, Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan Phone: +81-58-230-6349, Fax: +81-58-230-6348


Received: 2010-09-22

Accepted: 2010-09-24

Published Online: 2011-03-04

Published in Print: 2011-03-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 5, Issue 3, Pages 143–151, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/HMBCI.2010.049.

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©2011 by Walter de Gruyter Berlin New York.Get Permission

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