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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board Member: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi

4 Issues per year


CiteScore 2016: 2.15

SCImago Journal Rank (SJR) 2015: 0.432
Source Normalized Impact per Paper (SNIP) 2015: 0.334

Online
ISSN
1868-1891
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Volume 10, Issue 3 (Jun 2012)

Issues

Chemical and biochemical approaches to the production of 7-hydroxylated C19-steroids

Clotilde Ferroud
  • Laboratoire de Transformation Chimique et Pharmaceutique, ERL3193 CNRS/ESCPIParisTech/Cnam, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gilbert Revial
  • Laboratoire de Transformation Chimique et Pharmaceutique, ERL3193 CNRS/ESCPIParisTech/Cnam, Paris, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Robert Morfin
Published Online: 2012-05-03 | DOI: https://doi.org/10.1515/hmbci-2012-0013

Abstract

Interest has developed into 7-hydroxylated derivatives of 3β-hydroxylated C19-steroids, such as dehydroepiandrosterone (DHEA) and epiandrosterone because of their effects on inflammation, immune response, and cell repair. These steroids are not currently available from commercial sources, and it is necessary to produce them for relevant studies. We report here the chemical and biochemical approaches that were used for their production. Simplified chemical approaches lead to the production of 7α-/7β-hydroxy-DHEA and 7β-hydroxy-epiandrosterone in gram quantities, which are made available to researchers. Biochemical approaches were used to produce isotope-labeled compounds. Thus, 2H-, 3H-, and 14C-labeled 7α-/7β-hydroxy-DHEA and 7β-hydroxy-epiandrosterone could be produced in quantities sufficient for use in investigations into their mode of action.

Keywords: cell repair; 7α-hydroxy-DHEA; 7β-hydroxy-epiandrosterone; resolution of inflammation

About the article

Corresponding author: Robert Morfin, Laboratoire de Biotechnologie, Conservatoire National des Arts et Métiers, 2 rue Conté, 75003 Paris, France


Received: 2012-02-29

Accepted: 2012-04-03

Published Online: 2012-05-03

Published in Print: 2012-06-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/hmbci-2012-0013.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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