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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi


CiteScore 2018: 2.43

SCImago Journal Rank (SJR) 2018: 0.947
Source Normalized Impact per Paper (SNIP) 2018: 0.837

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1868-1891
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Volume 24, Issue 2

Issues

Insulin sensitivity affects corticolimbic brain responses to visual food cues in polycystic ovary syndrome patients

Hanin M. Alsaadi
  • Department of Biomedical and Molecular Sciences-Physiology, Queen’s University, Kingston, Ontario, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dean A. Van Vugt
  • Corresponding author
  • Department of Biomedical and Molecular Sciences-Physiology, Queen’s University, Kingston, Ontario, Canada
  • Department Obstetrics and Gynaecology, 3002 Etherington Hall, 94 Stuart St, Queen’s University Kingston, Ontario, K7L 3N6, Canada
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-11-27 | DOI: https://doi.org/10.1515/hmbci-2015-0048

Abstract

Background: This study examined the effect of insulin sensitivity on the responsiveness of appetite regulatory brain regions to visual food cues.

Materials and methods: Nineteen participants diagnosed with polycystic ovary syndrome (PCOS) were divided into insulin-sensitive (n=8) and insulin-resistant (n=11) groups based on the homeostatic model assessment of insulin resistance (HOMA2-IR). Subjects underwent functional magnetic resonance imaging (fMRI) while viewing food pictures following water or dextrose consumption. The corticolimbic blood oxygen level dependent (BOLD) responses to high-calorie (HC) or low-calorie (LC) food pictures were compared within and between groups.

Results: BOLD responses to food pictures were reduced during a glucose challenge in numerous corticolimbic brain regions in insulin-sensitive but not insulin-resistant subjects. Furthermore, the degree of insulin resistance positively correlated with the corticolimbic BOLD response in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), anterior cingulate and ventral tegmental area (VTA) in response to HC pictures, and in the dorsolateral prefrontal cortex (DLPFC), mPFC, anterior cingulate, and insula in response to LC pictures following a glucose challenge. BOLD signal in the OFC, midbrain, hippocampus, and amygdala following a glucose challenge correlated with HOMA2-IR in response to HC-LC pictures.

Conclusion: We conclude that the normal inhibition of corticolimbic brain responses to food pictures during a glucose challenge is compromised in insulin-resistant subjects. The increase in brain responsiveness to food pictures during postprandial hyperinsulinemia may lead to greater non-homeostatic eating and perpetuate obesity in insulin-resistant subjects.

Keywords: functional magnetic resonance imaging; glucose challenge; insulin resistance; polycystic ovary syndrome

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About the article

Corresponding author: Dean A. Van Vugt, PhD Professor, Department Obstetrics and Gynaecology, 3002 Etherington Hall, 94 Stuart St, Queen’s University Kingston, Ontario, K7L 3N6, Canada, Phone: +613 533 2899, Fax: +613 533 6779, E-mail: ; and Department of Biomedical and Molecular Sciences-Physiology, Queen’s University, Kingston, Ontario, Canada


Received: 2015-10-11

Accepted: 2015-10-29

Published Online: 2015-11-27

Published in Print: 2015-11-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 24, Issue 2, Pages 101–115, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/hmbci-2015-0048.

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