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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi

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Volume 25, Issue 3

Issues

Model approach for stress induced steroidal hormone cascade changes in severe mental diseases

Claus D. Volko / Pedro A. Regidor / Uwe D. Rohr
Published Online: 2016-01-23 | DOI: https://doi.org/10.1515/hmbci-2015-0038

Abstract

Introduction: Stress was described by Cushing and Selye as an adaptation to a foreign stressor by the anterior pituitary increasing ACTH, which stimulates the release of glucocorticoid and mineralocorticoid hormones. The question is raised whether stress can induce additional steroidal hormone cascade changes in severe mental diseases (SMD), since stress is the common denominator.

Methods: A systematic literature review was conducted in PubMed, where the steroidal hormone cascade of patients with SMD was compared to the impact of increasing stress on the steroidal hormone cascade (a) in healthy amateur marathon runners with no overtraining; (b) in healthy well-trained elite soldiers of a ranger training unit in North Norway, who were under extreme physical and mental stress, sleep deprivation, and insufficient calories for 1 week; and, (c) in soldiers suffering from post traumatic stress disorder (PTSD), schizophrenia (SI), and bipolar disorders (BD).

Results: (a) When physical stress is exposed moderately to healthy men and women for 3–5 days, as in the case of amateur marathon runners, only few steroidal hormones are altered. A mild reduction in testosterone, cholesterol and triglycerides is detected in blood and in saliva, but there was no decrease in estradiol. Conversely, there is an increase of the glucocorticoids, aldosterone and cortisol. Cellular immunity, but not specific immunity, is reduced for a short time in these subjects. (b) These changes are also seen in healthy elite soldiers exposed to extreme physical and mental stress but to a somewhat greater extent. For instance, the aldosterone is increased by a factor of three. (c) In SMD, an irreversible effect on the entire steroidal hormone cascade is detected. Hormones at the top of the cascade, such as cholesterol, dehydroepiandrosterone (DHEA), aldosterone and other glucocorticoids, are increased. However, testosterone and estradiol and their metabolites, and other hormones at the lower end of the cascade, seem to be reduced. 1) The rate and extent of reduction of the androgen metabolites may cause a decrease of cellular and specific immunity which can lead to viral and bacterial infections; joint and stomach inflammation; general pain; and allergic reactions. 2) The decrease in testosterone, and estradiol in SMD may have detrimental effects in cell repair as the estradiol metabolite, 2-methoxy-estradiol (2ME2), helps to transforms stem cells into functional cells. As dopamine and 2ME2 are inversely metabolized via various forms of catechol-O-methyl transferase (COMT), well-being and hypertension may be related. 2ME2 is related to vascular endothelial growth factor (VEGF), which regulates blood capillary growth and O2 supply. As reduced O2 is a key marker of stress, the increase of glucocorticoids in all forms of mental and physical stress cannot counterbalance the reduced 2ME2 in cellular and mental stress. The increased cholesterol and triglycerides are related to stroke and infarction, contributing to a reduced life expectancy in SMD between 14 and 20 years. The increase of aldosterone leads to increases in anxiety, edema, and lung infections.

Discussion: Increasing mental and physical stress is related to systematic deviations in the steroidal hormone cascade in the non-psychotic state, which then may cause life threatening co-morbidities in PTSD, SI, and BD.

Keywords: autism; bipolar disorder; cell differentiation; cholesterol; circadian rhythm; depression; edema; estradiol; HDL; hypertension; insomnia; metabolic disorder; p53; PTSD; schizophrenia; testosterone; triglycerides

References

  • 1.

    Hauger RL, Olivares-Reyes JA, Braun S, Hernandez-Aranda J, Hudson CC, Gutknecht E, Dautzenberg FM, Oakley RH. Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment. Regul Pept 2013;186:62–76.CrossrefGoogle Scholar

  • 2.

    Selye H. A syndrome produced by diverse nocuous agents. Nature (London) 1936;148:84–5.CrossrefGoogle Scholar

  • 3.

    Selye H. The general adaptation syndrome and the disease of adaptation. J Clin Endocrol 1946;6:117–230.CrossrefGoogle Scholar

  • 4.

    Selye H. The physiology and pathology of exposure to stress. Acta Inc Med Publ 1950;59:822–9.Google Scholar

  • 5.

    Selye H. “The stress of life”. New York, NY: McGraw-Hill, 1978:515.Google Scholar

  • 6.

    Selye H. The evolution of the stress concept. Am Sci 1970;61:692–9.Google Scholar

  • 7.

    Gocan A, Bachg NY, Schindler AE, Rohr UD. Balancing steroidal hormone cascade in treatment-resistant veteran soldiers with PTSD using a fermented soy product (FSWW08): a pilot study. Horm Mol Biol Clin Investig 2012;10:301–14.Google Scholar

  • 8.

    Söndergaard HP, Kushnir MM, Aronsson B, Sandstedt P, Bergquist J. Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress. BMC Res Notes 2012;5:186.CrossrefGoogle Scholar

  • 9.

    Boudou P, Fiet J, Laureaux C, Patricot MC, Guezennec CY, Foglietti MJ, Villette JM, Friemel F, Haag JC. [Changes in several plasma and urinary components in marathon runners]. Ann Biol Clin (Paris) 1987;45:37–45.Google Scholar

  • 10.

    Rehm KE, Elci OU, Hahn K, Marshall GD Jr. The impact of self-reported psychological stress levels on changes to peripheral blood immune biomarkers in recreational marathon runners during training and recovery. Neuroimmunomodulation 2013;20:164–76.CrossrefGoogle Scholar

  • 11.

    Williams PT. Lower prevalence of hypertension, hypercholesterolemia, and diabetes in marathoners. Med Sci Sports Exerc 2009;41:523–9.CrossrefGoogle Scholar

  • 12.

    Taipale RS, Mikkola J, Salo T, Hokka L, Vesterinen V, Kraemer WJ, Nummela A, Häkkinen K. Mixed maximal and explosive strength training in recreational endurance runners. J Strength Cond Res 2014;28:689–99.CrossrefGoogle Scholar

  • 13.

    Piacentini MF, Minganti C, Ferragina A, Ammendolia A, Capranica L, Cibelli G. Stress related changes during a half marathon in master endurance athletes. J Sports Med Phys Fitness 2015;55:329–36.Google Scholar

  • 14.

    Opstad PK. Androgenic hormones during prolonged physical stress, sleep and energy deficiency. J Clin Endocrinol Metab 1992;74:1176–83.Google Scholar

  • 15.

    Opstad PK. Alterations in the morning plasma levels of hormones and the endocrine responses to bicycle exercise during prolonged strain. The significance of energy and sleep deprivation. Acta Endocrinol 1991;125:14–22.Google Scholar

  • 16.

    Schendzielorz N, Rysa A, Reenila I, Raasmaja A, Mannisto PT. Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats. J Physiol Pharmacol 2011;62:483–90.Google Scholar

  • 17.

    Jiang H, Xie T, Ramsden DB, Ho SL. Human catechol-O-methyltransferase down-regulation by estradiol. Neuropharmacology 2003;45:1011–8.CrossrefGoogle Scholar

  • 18.

    Fredrikson DH, Boyda HN, Tse L, Whitney Z, Pattison MA, Ott FJ, Hansen L, Barr AM. Improving metabolic and cardiovascular health at an early psychosis intervention program in vancouver, Canada. Front Psychiatry 2014;5:105.CrossrefGoogle Scholar

  • 19.

    Schoepf D, Heun R. Bipolar disorder and comorbidity: increased prevalence and increased relevance of comorbidity for hospital-based mortality during a 12.5-year observation period in general hospital admissions. J Affect Disord 20141;169:170–8.Google Scholar

  • 20.

    Colton CW, Manderscheid RW. Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 2006;3:A42.Google Scholar

  • 21.

    Twamley EW, Hua JP, Burton CZ, Vella L, Chinh K, Bilder RM, Kelsoe JR. Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia. Schizophr Res 2014;159:114–7.CrossrefGoogle Scholar

  • 22.

    Opstad PK. The hypothalamo-pituitary regulation of androgenic secretion in young men after prolonged physical stress combined with energy and sleep deprivation. Acta Endocrinol 1992;127:231–6.Google Scholar

  • 23.

    Hullin RP, Levell MJ, O’Brien MJ, Toumba KJ. Inhibition of in vitro production of aldosterone by manic-depressive sera. Br J Psychiatry 1981;138:373–80.CrossrefGoogle Scholar

  • 24.

    Miller PD, Dubovsky SL, McDonald KM, Katz FH, Robertson GL, Schrier RW. Central, renal and adrenal effects of lithium in man. Am J Med 1979;66:797–803.CrossrefGoogle Scholar

  • 25.

    Champagne J, Lakis N, Bourque J, Stip E, Lipp O, Mendrek A. Progesterone and cerebral function during emotion processing in men and women with Schizophrenia. Schizophr Res Treatment 2012;2012:Article ID 917901.CrossrefGoogle Scholar

  • 26.

    Gallagher P, Watson S, Smith MS, Young AH, Ferrier IN. Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder. Schizophr Res 2007;90:258–65.CrossrefGoogle Scholar

  • 27.

    Zerouni C, Kummerow E, Martinez M, Diaz A, Ezequiel U, Wix-Ramos R. Affective disorder and hyperandrogenism. Recent Pat Endocr Metab Immune Drug Discov 2013;7:77–9.Google Scholar

  • 28.

    Wieck A. Estradiol and psychosis: clinical findings and biological mechanisms. Curr Top Behav Neurosci 2011;8:173–87.CrossrefGoogle Scholar

  • 29.

    Laan W1, Smeets H, de Wit NJ, Kahn RS, Grobbee DE, Burger H. Glucocorticosteroids associated with a decreased risk of psychosis. J Clin Psychopharmacol 2009;29:288–90.Google Scholar

  • 30.

    Rasgon NL, Kenna HA, Wong ML, Whybrow PC, Bauer M. Hypothalamic-pituitary-end organ function in women with bipolar depression. Psychoneuroendocrinology 2007;32:279–86.CrossrefGoogle Scholar

  • 31.

    Studd J. Severe premenstrual syndrome and bipolar disorder: a tragic confusion. Menopause Int 2012;18:82–6.Google Scholar

  • 32.

    Diflorio A, Jones I. Is sex important? Gender differences in bipolar disorder. Int Rev Psychiatry 2010;22:437–52.CrossrefGoogle Scholar

  • 33.

    Wosu AC, Gelaye B, Williams MA. Childhood sexual abuse and posttraumatic stress disorder among pregnant and postpartum women: review of the literature. Arch Womens Ment Health 2015;15:174.Google Scholar

  • 34.

    Mattocks KM, Skanderson M, Goulet JL, Brandt C, Womack J, Krebs E, Desai R, Justice A, Yano E, Haskell S. Pregnancy and mental health among women veterans returning from Iraq and Afghanistan. J Womens Health (Larchmt) 2010;19:2159–66.CrossrefGoogle Scholar

  • 35.

    Tegethoff, Greene N, Olsen J, Schaffner E, Meinlschmidt G. Stress during pregnancy and offspring pediatric disease: a national Cohort Study. Environ Health Perspect 2011;119: 1647–52.CrossrefGoogle Scholar

  • 36.

    Mendrek A, Stip E. Sexual dimorphism in schizophrenia: is there a need for gender-based protocols? Expert Rev Neurother 2011;11:951–68.CrossrefGoogle Scholar

  • 37.

    Hange D, Mehlig K, Lissner L, Guo X, Bengtsson C, Skoog I, Björkelund C. Perceived mental stress in women associated with psychosomatic symptoms, but not mortality: observations from the Population Study of Women in Gothenburg, Sweden. Int J Gen Med 2013;6:307–15.CrossrefGoogle Scholar

  • 38.

    Ishtiak-Ahmed K, Perski A, Mittendorfer-Rutz E. Predictors of suicidal behaviour in 36,304 individuals sickness absent due to stress-related mental disorders – a Swedish register linkage cohort study. BMC Public Health 2013;13:492.Google Scholar

  • 39.

    Durocher JJ, Klein JC, Carter JR. Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans. Am J Physiol Heart Circ Physiol 2011;300: H1788–93.Google Scholar

  • 40.

    Opstad PK, Brätveit M, Wiik P, Boyum A. The dynamic response of adrenoceptors in human blood cells to prolonged exhausting stain, sleep and energy deficiency. Biogenic Amines 1994;10:329–44.Google Scholar

  • 41.

    Opstad PK, Wiik P, Haugen AH, Skrede KK. Adrenaline stimulated cyclic adenosine monophosphate response in leucocytes is reduced after prolonged physical activity combined with sleep and energy deprivation. Eur J Appl Physiol 1994;69:371–75.CrossrefGoogle Scholar

  • 42.

    Opstad PK. Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men. Eur J Endocrinol 1994;131:56–66.CrossrefGoogle Scholar

  • 43.

    Morley JE, Benton D, Solomon GF. The role of stress and opioids as regulators of the immune response In: McCubbin JA, Kaufmann PG, Nemeroff CB, editors. Stress, neuropeptides, and systemic disease. San Diego, CA: Academic Press Inc., 1991:221–31.Google Scholar

  • 44.

    Zimmerman HJ, Henry JB. Serum enzyme determinations as an aid to diagnosis, In: Davidsohn I, Henry JB, editors. Clinical diagnosis by laboratory methods. Philadelphia, PA: WB Saunders Company, 1974:837–69.Google Scholar

  • 45.

    Loegering DJ, Bonin ML, Smith JJ. Effects of exercise, hypoxia, and epinephrine on lysosomes and plasma enzymes. Exp Mol Pathol 1975;22:242–51.CrossrefGoogle Scholar

  • 46.

    Oktedalen O, Nesland A, Opstad PK, Berstad A. The influence of prolonged physical stress on gastric acid concentration in healthy man. Scand J Gastroenterol 1988;23:1132–6.CrossrefGoogle Scholar

  • 47.

    Loria RM. Beta-androstenes and resistance to viral and bacterial infections. Neuroimmunomodulation 2009;16:88–95.CrossrefGoogle Scholar

  • 48.

    Glaesmer H, Brähler E, Gündel H, Riedel-Heller SG. The association of traumatic experiences and posttraumatic stress disorder with physical morbidity in old age: a German population-based study. Psychosom Med 2011;73:401–6.CrossrefGoogle Scholar

  • 49.

    Perugi G, Quaranta G, Belletti S, Casalini F, Mosti N, Toni C, Dell’Osso L. General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J Affect Disord 2015;170:95–103.CrossrefGoogle Scholar

  • 50.

    Teixeira PJ, Porto L, Kristensen CH, Santos AH, Menna-Barreto SS, Prado-Lima PA. Post-traumatic stress symptoms and exacerbations in COPD patients. COPD 2015;12:90–5.CrossrefGoogle Scholar

  • 51.

    Spitzer C, Koch B, Grabe HJ, Ewert R, Barnow S, Felix SB, Ittermann T, Obst A, Völzke H, Gläser S, Schäper C. Association of airflow limitation with trauma exposure and post-traumatic stress disorder. Eur Respir J 2011;37:1068–75.CrossrefGoogle Scholar

  • 52.

    Hsu JH, Chien IC, Lin CH, Chou YJ, Chou P. Increased risk of chronic obstructive pulmonary disease in patients with schizophrenia: a population-based study. Psychosomatics 2013;54:345–51.CrossrefGoogle Scholar

  • 53.

    Robillard R, Rogers NL, Whitwell BG, Lambert T. Are cardiometabolic and endocrine abnormalities linked to sleep difficulties in schizophrenia? A hypothesis driven review. Clin Psychopharmacol Neurosci 2012;10:1–12.CrossrefGoogle Scholar

  • 54.

    Goel N, Banks S, Lin L, Mignot E, Dinges DF. Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. PLoS One 2011;6:e29283.CrossrefGoogle Scholar

  • 55.

    Depp CA, Strassnig M, Mausbach BT, Bowie CR, Wolyniec P, Thornquist MH, Luke JR, McGrath JA, Pulver AE, Patterson TL, Harvey PD. Association of obesity and treated hypertension and diabetes with cognitive ability in bipolar disorder and schizophrenia. Bipolar Disord 2014;16:422–31.CrossrefGoogle Scholar

  • 56.

    Ciocca G, Carosa E, Stornelli M, Limoncin E, Gravina GL, Iannarelli R, Sperandio A, Di Sante S, Lenzi A, Lauro D, Jannini EA. Post-traumatic stress disorder, coping strategies and type 2 diabetes: psychometric assessment after L’Aquila earthquake. Acta Diabetol 2015;52:513–21.CrossrefGoogle Scholar

  • 57.

    Ko YH. Association between serum testosterone levels and the severity of negative symptoms in male patients with chronic schizophrenia. Psychoneuroendocrinology 2007;32:385–91.CrossrefGoogle Scholar

  • 58.

    Goyal RO. Negative correlation between negative symptoms of schizophrenia and testosterone levels. Ann N Y Acad Sci 2004;1032:291–4.Google Scholar

  • 59.

    Henry NL1, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ, Hayes DF. Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms. Cancer 2011;117:5469–75.Google Scholar

  • 60.

    Huber J, Schneeberger C, Tempfer CB. Genetic modeling of oestrogen metabolism as a risk factor of hormone-dependent disorders. Maturitas 2002;41;55–64.CrossrefGoogle Scholar

  • 61.

    Studd J. Personal view: hormones and depression in women. Climacteric 2015;18:3–5.CrossrefGoogle Scholar

  • 62.

    Craparo G, Gori A, Mazzola E, Petruccelli I, Pellerone M, Rotondo G. Posttraumatic stress symptoms, dissociation, and alexithymia in an Italian sample of flood victims. Neuropsychiatr Dis Treat 2014;10:2281–4.CrossrefGoogle Scholar

  • 63.

    Tofovic SP. Oestrogens and development of pulmonary hypertension: interaction of Estradiol metabolism and pulmonary vascular disease. J Cardiovasc Pharmacol 2010;56: 696–708.CrossrefGoogle Scholar

  • 64.

    Clark-Raymond A, Meresh E, Hoppensteadt D, Fareed J, Sinacore J, Halaris A. Vascular endothelial growth factor: a potential diagnostic biomarker for major depression. J Psychiatr Res 2014;59:22–7.CrossrefGoogle Scholar

  • 65.

    Kubzansky LD, Adler GK. Aldosterone: a forgotten mediator of the relationship between psychological stress and heart disease. Neurosci Biobehav Rev 2010;34:80–6.CrossrefGoogle Scholar

  • 66.

    Foldager L, Köhler O, Steffensen R, Thiel S, Kristensen AS, Jensenius JC, Mors O. Bipolar and panic disorders may be associated with hereditary defects in the innate immune system. AffectDisord 201;164:148–54.Google Scholar

  • 67.

    Kliushnik TP, Zozulia SA, Androsova LV, Sarmanova ZV, Otman IN, Dupin AM, Panteleeva GP, Oleĭchik IV, Abramova LI, Stoliarov SA, Shipilova ES, Borisova OA. Immunological monitoring of endogenous attack-like psychoses. Zh Nevrol Psikhiatr Im S S Korsakova 2014;114:37–41.Google Scholar

  • 68.

    Hamdani N, Tamouza R, Leboyer M. Immuno-inflammatory markers of bipolar disorder: a review of evidence. Front Biosci (Elite Ed) 2012;4:2170–82.CrossrefGoogle Scholar

  • 69.

    Sainz J, Mata I, Barrera J, Perez-Iglesias R, Varela I, Arranz MJ, Rodriguez MC, Crespo-Facorro B. Inflammatory and immune response genes have significantly altered expression in schizophrenia. Mol Psychiatry 2013;18:1056–7.CrossrefGoogle Scholar

  • 70.

    Canadian Agency for Drugs and Technologies in Health Hyperbaric Oxygen Therapy for Adults with Mental Illness: A Review of the Clinical Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Aug 27.Google Scholar

  • 71.

    Hoge CW, Castro CA. Treatment of generalized war-related health concerns: placing TBI and PTSD in context. J Am Med Assoc 2014;312:1685–6.CrossrefGoogle Scholar

  • 72.

    Brand S, Otte D, Petri M, Decker S, Stübig T, Krettek C, Müller CW. Incidence of posttraumatic stress disorder after traffic accidents in Germany. Int J Emerg Ment Health 2014;16: 233–6.CrossrefGoogle Scholar

  • 73.

    Baron-Cohen S, Auyeung B, Nørgaard-Pedersen B, Hougaard DM, Abdallah MW, Melgaard L, Cohen AS, Chakrabarti B, Ruta L, Lombardo MV. Elevated fetal steroidogenic activity in autism. Mol Psychiatry 2015;20:369–76.CrossrefGoogle Scholar

  • 74.

    Auyeung B, Ahluwalia J, Thomson L, Taylor K, Hackett G, O’Donnell KJ, Baron-Cohen S. Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age. Mol Autism 2012;3:17.CrossrefGoogle Scholar

  • 75.

    Baker ME, Nelson DR, Studer RA. Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors. J Steroid Biochem Mol Biol 2015;151:12–24.CrossrefGoogle Scholar

  • 76.

    López-Maury L1, Marguerat S, Bähler J. Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat Rev Genet 2008;9:583–93.Google Scholar

  • 77.

    Atkinson NJ, Urwin PE. The interaction of plant biotic and abiotic stresses: from genes to the field. J Exp Bot 2012;63:3523–43.CrossrefGoogle Scholar

  • 78.

    Rizhsky L, Liang HJ, Shuman J, Shulaev V, Davletova S, Mittler R. When defense pathways collide. The response of Arabidopsis to a combination of drought and heat stress. Plant Physiol 2004;134:1683–96.CrossrefGoogle Scholar

  • 79.

    Soares AS, Marchiosi R, de Cássia Siqueira-Soares R, Barbosa de Lima RB, Dantas dos Santos W, Ferrarese-Filho O. The role of L-DOPA in plants. Plant Signal Behav 2014;9:e28275.CrossrefGoogle Scholar

  • 80.

    Xiao L, Becker JB. Effects of oestrogen agonists on amphetamine-stimulated striatal dopamine release. Synapse 1998;29:379–91.CrossrefGoogle Scholar

  • 81.

    Thibaut M, Ribeyre JM, Dourmap N, Meloni R, Laurent C, Campion D, Ménard JF, Dollfus S, Mallet J, Petit M. Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia. Schizophrenia Research 1997;23:259–64.CrossrefGoogle Scholar

  • 82.

    Smith CT, Sierra Y, Oppler SH, Boettiger CA. Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. J Neurosci 2014;34:5468–76.CrossrefGoogle Scholar

  • 83.

    Kelm MK, Boettiger CA. Effects of acute dopamine precusor depletion on immediate reward selection bias and working memory depend on catechol-O-methyltransferase genotype. J Cogn Neurosci 2013;25:2061–71.CrossrefGoogle Scholar

  • 84.

    Purves-Tyson TD, Handelsman DJ, Double KL, Owens SJ, Bustamante S, Weickert CS. Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC Neurosci 2012;13:95.CrossrefGoogle Scholar

  • 85.

    Comasco E, Hellgren C, Sundström-Poromaa I. Influence of catechol-O-methyltransferase Val158Met polymorphism on startle response in the presence of high estradiol levels. Eur Neuropsychopharmacol 2013;23:629–35.CrossrefGoogle Scholar

  • 86.

    Jacobs E, D’Esposito M. Estrogen shapes dopamine-dependent cognitive processes: implications for women’s health. J Neurosci 2011;31:5286–93.CrossrefGoogle Scholar

  • 87.

    Chaube R, Joy KP. In vitro effects of catecholamines and catecholoestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis. J Neuroendocrinol 2003;15:273–9.CrossrefGoogle Scholar

  • 88.

    Aguero J, Ishikawa K, Hadri L, Santos-Gallego C, Fish K, Hammoudi N, Chaanine A, Torquato S, Naim C, Ibanez B, Pereda D, García-Alvarez A, Fuster V, Sengupta PP, Leopold JA, Hajjar RJ. Characterization of right ventricular remodeling and failure in a chronic pulmonary hypertension model. Am J Physiol Heart Circ Physiol 2014;307:H1204–15.Google Scholar

  • 89.

    Donato V, Lacquaniti A, Cernaro V, Lorenzano G, Trimboli D, Buemi A, Lupica R, Buemi M. From water to aquaretics: a legendary route. Cell Physiol Biochem 2014;33:1369–88.CrossrefGoogle Scholar

  • 90.

    Colombo L, Dalla Valle L, Fiore C, Armanini D, Belvedere P. Aldosterone and the conquest of land. J Endocrinol Invest 2006;29:373–9.CrossrefGoogle Scholar

  • 91.

    Xiao M, Inal CE, Parekh VI, Chang CM, Whitnall MH. 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression. Mol Pharmacol 2007;72: 370–9.CrossrefGoogle Scholar

  • 92.

    Dey P, Ström A, Gustafsson JÅ. Oestrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene 2014;33:4213–25.CrossrefGoogle Scholar

  • 93.

    Yoshiyama KO, Kimura S, Maki H, Britt AB, Umeda M. The role of SOG1, a plant-specific transcriptional regulator, in the DNA damage response. Plant Signal Behav 2014;9:e28889.CrossrefGoogle Scholar

  • 94.

    Tagawa N, Hidaka Y, Takano T, Shimaoka Y, Kobayashi Y, Amino N. Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after normal pregnancy. Steroids 2004;69: 675–80.CrossrefGoogle Scholar

  • 95.

    Yeap BB, Alfonso H, Chubb SA, Hankey GJ, Handelsman DJ, Golledge J, Almeida OP, Flicker L, Norman PE. In older men, higher plasma testosterone or dihydrotestosterone is an independent predictor for reduced incidence of stroke but not myocardial infarction. J Clin Endocrinol Metab 2014;99:4565–73.CrossrefGoogle Scholar

  • 96.

    Swaab DF1, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 2005;4:141–94.Google Scholar

  • 97.

    Katon J, Mattocks K, Zephyrin L, Reiber G, Yano EM, Callegari L, Schwarz EB, Goulet J, Shaw J, Brandt C, Haskell S. Gestational diabetes and hypertensive disorders of pregnancy among women veterans deployed in service of operations in Afghanistan and Iraq. J Womens Health (Larchmt) 2014;23:792–800.CrossrefGoogle Scholar

  • 98.

    Shaw JG, Asch SM, Kimerling R, Frayne SM, Shaw KA, Phibbs CS. Posttraumatic stress disorder and risk of spontaneous preterm birth. Obstet Gynecol 2014;124:1111–9.CrossrefGoogle Scholar

  • 99.

    Lee SB, Wong AP, Kanasaki K, Xu Y, Shenoy VK, McElrath TF, Whitesides GM, Kalluri R. Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. Am J Pathol 2010;176:710–20.CrossrefGoogle Scholar

About the article

Corresponding author: Uwe D. Rohr, MD PhD PhD, Endobal Medical Research Corporation, 1101 E. Tropicanan Av, #3006, Las Vegas, NV 89119, USA, E-mail:


Received: 2015-08-13

Accepted: 2015-11-24

Published Online: 2016-01-23

Published in Print: 2016-03-01


Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 25, Issue 3, Pages 157–170, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: https://doi.org/10.1515/hmbci-2015-0038.

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