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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi

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Volume 31, Issue 3


Interplay between PAPP-A, inflammation and adiposity in patients with angiographically proven acute coronary syndrome (ACS)

Khageshwar Mahato / Moushumi Lodh
  • Department of Biochemistry, IQ City Medical College and Narayana Multispeciality Hospital, Durgapur, West Bengal, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ashok Parida
  • Department of Cardiology, IQ City Medical College and Narayana Multispeciality Hospital, Durgapur, West Bengal, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ashok Kr Ahirwar / Rashmi Rasi Datta / Binita Goswami
  • Corresponding author
  • Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India, Phone: + 91-98105-92004
  • Email
  • Other articles by this author:
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Published Online: 2017-06-21 | DOI: https://doi.org/10.1515/hmbci-2016-0056



Studies conducted in the recent past have demonstrated the role of inflammation, obesity and dysfunctional insulin signaling as contributing factors in the pathogenesis of acute coronary syndrome (ACS). However, pharmacological interventions targeting a single pathway have not proven useful in the long run. This indicates that a synergism occurs between the various risk factors and hence calls for a combinatorial approach. This study was planned to study the interplay, if any, between pregnancy associated plasma protein-A (PAPP-A), inflammation and adiposity in patients with ACS.

Materials and methods

The study was conducted in a tertiary care hospital in Delhi. The study population consisted of 128 subjects, divided into two groups. The control group consisted of 64 healthy subjects without ACS. Cases consisted of 64 subjects with angiographically proven ACS cases. PAPP-A and high sensitivity C-reactive protein (hs-CRP) were estimated by enzyme-linked immunosorbent assay (ELIZA) kits.


The mean level of PAPP-A and hs-CRP were significantly higher in cases as compared to the controls. A positive correlation of PAPP-A was observed with hs-CRP, insulin, ApoB and Lp(a). The relative risk for ACS was 14.2 with a p value of <0.001 when all the three parameters – hs-CRP, PAPP-A and body mass index (BMI) were considered together. This was significantly higher when each risk factor was assessed standalone.


Our study results suggest a possible interplay between chronic inflammation, obesity and plaque instability among patients with ACS. This interaction can accelerate the process of plaque rupture in patients with increased BMI as compare to those patients with low/normal BMI.

Keywords: acute coronary syndrome; body mass index; hsC reactive protein; pregnancy associated plasma protein-A; relative risk

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About the article

Received: 2016-12-13

Accepted: 2017-02-20

Published Online: 2017-06-21

Author statement

Research Funding: The authors state that no funding was involved.

Conflict of interest: The authors state that they have no conflict of interest.

Informed consent: Informed consent has been obtained from all the individuals obtained in this study.

Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance to the tenets of the Helsinki Declaration.

Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 31, Issue 3, 20160056, ISSN (Online) 1868-1891, DOI: https://doi.org/10.1515/hmbci-2016-0056.

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