Eli Lilly. ZYPREXA RELPREVV. Highlights of prescribing information Available from: http://pi.lilly.com/us/zyprexa_relprevv.pdf. Accessed: August 7, 2015. Literature revised July 23, 2015.
Kapur S, Langlois X, Vinken P, Megens AA, De Coster R, Andrews JS. The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats. J Pharmacol Exp Ther. 2002;302:129–34.Google Scholar
Kane JM, Sanchez R, Perry PP, Jin N, Johnson BR, Forbes RA, et al. Aripiprazole intramuscular depot as maintenance treatment in patients with schizophrenia: a 52-week, multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2012;73:617–24.PubMedCrossrefGoogle Scholar
Gentile S. Adverse effects associated with second-generation antipsychotic long-acting injection treatment: a comprehensive, systematic review. Pharmacotherapy. 2013;33:1087–106.PubMedCrossrefGoogle Scholar
Nasrallah HA, Gopal S, Gassmann-Mayer C, Quiroz JA, Lim P, Eerdekens M, et al. A controlled, evidence-based trial of paliperidone palmitate, a long-acting injectable antipsychotic, in schizophrenia. Neuropsychopharmacology. 2010;35:2072–82.PubMedCrossrefGoogle Scholar
INVEGA SUSTENNA® Product Monograph – http://www.janssen.ca/product/169. Accessed: August 8, 2015.
Lauriello J, Lambert T, Andersen S, Lin D, Taylor CC, McDonnell D. An 8-week, double-blind, randomized, placebo-controlled study of olanzapine long-acting injection in acutely ill patients with schizophrenia. J Clin Psychiatry. 2008;69:790–9.PubMedCrossrefGoogle Scholar
RISPERDAL® CONSTA® PRESCRIBING INFORMATION https://www.risperdalconsta.com/sites/default/files/RisperdalConstaPI.pdf. Accessed: August 7, 2015.
Lucca JM, Ramesh M, Parthasarathi G, Ram D. Incidence and factors associated with medication nonadherence in patients with mental illness: a cross-sectional study. J Postgrad Med. 2015;61:251–6.CrossrefPubMedGoogle Scholar
Reckitt Benckiser Pharmaceuticals Inc. Multiple ascending dose study of the safety, tolerability, pharmacokinetic/efficacy. Bethesda, MD: National Library of Medicine (US). Available at: http://clinicaltrials.gov/show/ NCT01677377 2000. Accessed November 12, 2015.
Johnson & Johnson. Janssen submits new drug application to U.S. FDA for three-month paliperidone palmitate first long-acting treatment to be used four times a year for schizophrenia in adults November 19, 2014. http://www.investor.jnj.com/releasedetail.cfm?releaseid = 883843. Accessed: August 10, 2015.
Berwaerts J, Liu Y, Gopal S, Nuamah I, Xu H, Savitz A, et al. Efficacy and safety of the 3-month formulation of paliperidone palmitate vs placebo for relapse prevention of schizophrenia. A randomized clinical trial. J Am Med Assoc Psychiatry. 2015;72:830–9.Google Scholar
Alkermes Inc. BiotechnologyEvents.Com. 2015 Alkermes’ New Drug Application for Aripiprazole Lauroxil for Treatment of Schizophrenia Accepted for Filing by U.S. FDA. http://www.biotechnologyevents.com/node/9099. Accessed: October 8, 2015.
Meltzer HY, Risinger R, Nasrallah HA, Zummo J, Corey L, Bose A, et al. A randomized, double-blind, placebo-controlled trial of aripiprazole lauroxil in acute exacerbation of schizophrenia. J Clin Psychiatry. 2015;76:1085–90.CrossrefPubMedGoogle Scholar
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) statement. Syst Rev. 2015;4:1 .CrossrefPubMedGoogle Scholar
Guyatt GH, Oxman AD, Kunz R. GRADE guidelines: 1, Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;66:383–94.Google Scholar
Wolters Kluver Health. UpToDate Grading Guide. Available from: http://www.uptodate.com/home/grading-guide. Accessed: October 7, 2015.
Kane JM, Sanchez R, Zhao J, Baker RA, Eramo A, McQuade RD, et al. Hospitalisation rates in patients switched from oral anti-psychotics to aripiprazole once-monthly for the management of schizophrenia. J Med Econom. 2013;6:917–25.Google Scholar
Fleischhacker WW, Sanchez R, Perry PP, Jin N, Peters-Strickland T, Johnson BR, et al. Aripiprazole once-monthly for treatment of schizophrenia: double-blind, randomised, non-inferiority study. Br J Psychiatry. 2014;205:135–44.PubMedCrossrefGoogle Scholar
Naber D, Hansen K, Forray C, Baker RA, Sapin C, Beillat M, et al. Qualify: a randomized head-to-head study of aripiprazole once-monthly and paliperidone palmitate in the treatment of schizophrenia. Schizophr Res. 2015;168:498–504.PubMedCrossrefGoogle Scholar
Ishigooka J, Nakamura J, Fujii Y, Iwata N, Kishimoto T, Iyo M, et al. ALPHA Study Group. Efficacy and safety of aripiprazole once-monthly in Asian patients with schizophrenia: a multicenter, randomized, double-blind, non-inferiority study versus oral aripiprazole. Schizophr Res. 2015;161:421–8.CrossrefPubMedGoogle Scholar
Nasrallah HA, Newcomer JW, Risinger R, Du Y, Zummo J, Bose A, et al. Effect of aripiprazole lauroxil on metabolic and endocrine profiles and related safety considerations among patients with acute schizophrenia. J Clin Psychiatry. 2016;77:1519–25.CrossrefGoogle Scholar
Lewis SW, Barnes TR, Davies L, Murray RM, Dunn G, Hayhurst KP, et al. Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia. Schizophr Bull. 2006;32:715–23.PubMedGoogle Scholar
Detke HC, Weiden PJ, Llorca PM, Choukour M, Watson SB, Brunner E, Ascher-Svanum H. Comparison of olanzapine long-acting injection and oral olanzapine. A 2-year, randomized, open-label study in outpatients with schizophrenia. J Clin Psychopharmacol. 2014;34:426–34.PubMedCrossrefGoogle Scholar
McDonnell D, Landry J, Detke HC. Long-term safety and efficacy of olanzapine long-acting injection in patients with schizophrenia or schizoaffective disorder: a 6-year, multinational, single-arm, open-label study. Int Clin Psychopharmacol. 2014;29:322–31.PubMedCrossrefGoogle Scholar
Bushe CJ, Falk D, Anand E, Asillas M, Perrin E, Chhabra-Khanna R, et al. Olanzapine long-acting injection: a review of first experiences of post-injection delirium/sedation syndrome in routine clinical practice. BMC Psychiatry. 2015;15:65.CrossrefPubMedGoogle Scholar
Kane JM, Detke HC, Naber D, Ethuraman G, Lin DY, Bergstrom RF, et al. Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia. Am J Psychiatry. 2010;167:181–9.PubMedCrossrefGoogle Scholar
EMEA/608654/2008. EMEA. Assessment report for Zyphadera. Accessed August 9, 2015 http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Public_assessment_report/human/000890/WC500054428.pdf.
McDonnell DP, Detke HC, Bergstrom RF, Kothare P, Johnson J, Stickelmeyer M. Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism. BMC Psychiatry. 2010;10:45.CrossrefPubMedGoogle Scholar
McEvoy JP, Byerly M, Hamer RM, Dominik R, Swartz MS, Rosenheck RA, et al. Effectiveness of paliperidone palmitate vs. haloperidol decanoate for maintenance treatment of schizophrenia. A randomized clinical trial. J Am Med Assoc. 2014;311:1978–86.CrossrefGoogle Scholar
Si T, Zhang K, Tang J, Fang M, Li K, Zhuo J, et al. Efficacy and safety of flexibly dosed paliperidone palmitate in Chinese patients with acute schizophrenia: an open-label, single-arm, prospective, interventional study. Neuropsy Dis Treat. 2015;11:1483–92.Google Scholar
Zhang F, Si T, Chiou CF, Harris AW, Kim CY, Jahagirdar P, et al. Efficacy, safety, and impact on hospitalizations of paliperidone palmitate in recent-onset schizophrenia. Neuropsy Dis Treat. 2015;11:657–68.Google Scholar
Schreiner A, Bergmans P, Cherubin P, Keim S, Llorca PM, Cosar B, et al. Paliperidone palmitate in non-acute patients with schizophrenia previously unsuccessfully treated with risperidone long-acting therapy or frequently used conventional depot antipsychotics. J Psychopharmacol. 2015;29:910–22.CrossrefPubMedGoogle Scholar
Hargarter L, Cherubin P, Bergmans P, Keim S, Rancans E, Bez Y, et al. Intramuscular long-acting paliperidone palmitate in acute patients with schizophrenia unsuccessfully treated with oral antipsychotics. Progr NeuroPsychopharm Biol Psychiatry. 2015;58:1–7.CrossrefGoogle Scholar
Fu DJ, Turkoz I, Simonson B, Walling D, Schooler N, Lindenmayer JP, et al. Paliperidone palmitate once-monthly injectable reduce risk of relapse of psychotic, depressive, and manic symptoms and maintains functioning in a double-blind, randomized study of schizoaffective disorder. J Clin Psychiatry. 2015;6:263–72.Google Scholar
Fu DJ, Turkoz I, Simonson B, Walling D, Schooler N, Lindenmayer JP, et al. Paliperidone palmitate once-monthly injectable treatment for acute exacerbations of schizoaffective disorder. J Clin Psychopharmacol. 2016;36:372–6.PubMedCrossrefGoogle Scholar
Alphs L, Benson C, Cheshire-Kinney K, Lindenmayer JP, Mao L, Rodriguez SC, et al. Real-world outcomes of paliperidone palmitate compared to daily oral antipsychotic therapy in schizophrenia: an randomized, open-label, review-board blinded 15-month study. J Clin Psychiatry. 2015;76:554–61.CrossrefPubMedGoogle Scholar
Alphs L, Mao L, Lynn Starr H, Benson C. Pragmatic analysis comparing once-monthly paliperidone palmitate versus daily oral antipsychotic treatment in patients with schizophrenia. Schizophr Res. 2016;170:259–64.CrossrefPubMedGoogle Scholar
Kim E, Correll CU, Mao L, Starr HL, Larry Alphs L. Once-monthly paliperidone palmitate compared with conventional and atypical daily oral antipsychotic treatment in patients with schizophrenia. CNS Spectrums. 2016;21:466–77.PubMedCrossrefGoogle Scholar
Schreiner A, Aadamsoo K, Altamura C, Franco M, Gorwood P, Neznanov NG, et al. Paliperidone palmitate versus oral antipsychotics in recently diagnosed schizophrenia. Schizophr Res. 2015;169:393–9.CrossrefPubMedGoogle Scholar
Li H, Turkoz I, Zhang F. Efficacy and safety of once-monthly injection of paliperidone palmitate in hospitalized Asian patients with acute exacerbated schizophrenia: an open-label, prospective, noncomparative study. Neuropsychiatr Dis Treat. 2016;12:15–24.PubMedGoogle Scholar
Rosso G, Pessina E, Martini A, Di Salvo G, Maina G. Paliperidone palmitate and metabolic syndrome in patients with schizophrenia. A 12-month observational prospective cohort study. J Clin Psychopharmacol. 2016;36:206–12.PubMedCrossrefGoogle Scholar
Ravenstijn P, Remmerie RB, Savitz A, Samtani MN, Nuamah I, Chang CT, et al. Pharmacokinetics, safety, and tolerability of paliperidone palmitate 3-month formulation in patients with schizophrenia: a Phase-1, single-dose, randomized, open-label study. J Clin Pharmacol. 2016;56:330–9.CrossrefPubMedGoogle Scholar
Savitz AJ, Xu H, Gopal S, Nuamah I, Ravenstijn P, Janik A, et al. Efficacy and safety of paliperidone palmitate 3-month formulation for patients with schizophrenia: a randomized, multicenter, double-blind, noninferiority study. Int J Neuropsychopharmacol. 2016;19: pii: pyw01819.PubMedGoogle Scholar
Lee NY, Kim SH, Cho SJ, Chung YC, Jung IK, Kimj CY, et al. A prospective, open-label study to evaluate symptomatic remission in schizophrenia with risperidone long-acting injectable in Korea. Int Clin Psychopharmacol. 2014;29:279–87.PubMedCrossrefGoogle Scholar
Fernández-Miranda JJ, Caramés-García V, Sánchez-García A. Effectiveness, good tolerability, and high compliance of doses of risperidone long-acting injectable higher than 75 mg in people with severe schizophrenia. A 3-year follow-up. J Clin Psychopharmacol. 2015;35:1–5.Google Scholar
Giraud-Baro E, Dassa D, De Vathaire F, Garay RP, Obeid J. Schizophrenia-spectrum patients treated with long-acting injectable risperidone in real-life clinical settings: functional recovery in remitted versus stable, non-remitted patients (the EVeREST prospective observational cohort study). BMC Psychiatry. 2016;16:8.CrossrefPubMedGoogle Scholar
Nasser AF, Henderson DC, Fava M, Fudala PJ, Twumasi-Ankrah P, Kouassi A, et al. Efficacy, safety, and tolerability of RBP-7000 once-monthly risperidone for the treatment of acute schizophrenia. An 8-week, randomized, double-blind, placebo-controlled, multicenter phase 3 study. J Clin Psychopharmacol 2016. 36;130–40.Google Scholar
FDA Safety. What is a serious adverse event? Last update: 01/10/2014. http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm. Accessed January 2016.
FDA Drug Safety Communication: FDA warns about new impulse-control problems associated with mental health drug aripiprazole (Abilify, Abilify Maintena, Aristada). Accessed may 12, 2016 http://www.fda.gov/Drugs/DrugSafety/ucm498662.htm.Google Scholar
FDA Drug Safety Communication. FDA is investigating two deaths following injection of long-acting antipsychotic Zyprexa Relprevv (olanzapine pamoate). 2013. Accessed August 14, 2015 http://www.fda.gov/Drugs/DrugSafety/ucm356971.htm.Google Scholar
FDA Drug Safety Communication. FDA review of study sheds light on two deaths associated with the injectable schizophrenia drug Zyprexa Relprevv (olanzapine pamoate). 2015. Accessed August 14, 2015 http://www.fda.gov/Drugs/DrugSafety/ucm439147.htm.Google Scholar
PHARMAFILE. FDA issues warning about rare, but serious, side effect in Lilly antipsychotic drug. http://www.pharmafile.com/news/504420/fda-issues-warning-about-rare-serious-side-effect-lilly-antipsychotic-drug. Accessed May 12, 2016.
FDA Warns of Rare but Serious Skin Reaction Reportedly Linked to Olanzapine. http://alert.psychnews.org/2016/05/fda-warns-of-rare-but-serious-skin.html. Accessed: January 30, 2016.
Nielsen J, Jensen SO, Friis RB, Valentin JB, Correll CU. Comparative effectiveness of risperidone long-acting injectable vs first-generation antipsychotic long-acting injectables in schizophrenia: Results from a nationwide, retrospective inception cohort study. Schizophr Bull. 2015;41:627–36.PubMedCrossrefGoogle Scholar
Suzuki H, Hibino H, Inoue Y, Takaya A. Comparison of hospitalization risk before and after changing from risperidone long-acting injection to another long-acting injection or oral antipsychotic in patients with schizophrenia: Mirror-image study. Psy Clin Neurosci. 2016;70:365–6.CrossrefGoogle Scholar
Sampson S, Hosalli P, Furtado VA, Davis JM. Risperidone (depot) for schizophrenia. Cochr Database Sys Rev. 2016;4:CD00416.Google Scholar
Rosenheck RA, Leslie DL, Sint KJ, Lin H, Li Y, McEvoy JP, et al. Cost-effectiveness of long-acting injectable paliperidone palmitate versus haloperidol decanoate in maintenance treatment of schizophrenia. Psychiatr Serv. 2016;67:1124–30.PubMedCrossrefGoogle Scholar
Marcus SC, Zummo J, Pettit AR, Stoddard J, Jalpa A, Doshi JA. Antipsychotic adherence and rehospitalization in schizophrenia patients receiving oral versus long-acting injectable antipsychotics following hospital discharge. J Manag Care Spec Pharm. 2015;21:754–68.PubMedGoogle Scholar
Cordiner M, Shajahan P, McAvoy S, Bashir M, Taylor M. Effectiveness of long-acting antipsychotics in clinical practice: 1. A retrospective, 18-month follow up and comparison between paliperidone palmitate, risperidone long-acting injection and zuclopenthixol decanoate. Ther Adv Psychopharmacol. 2016;6:22–32.CrossrefGoogle Scholar
Alphs L, Nasrallah HA, Bossie CA, Fu DJ, Gopal S, Hough D, et al. Factors associated with relapse in schizophrenia despite adherence to long-acting injectable antipsychotic therapy. Int Clin Psychopharmacol. 2016;31:202–9.CrossrefPubMedGoogle Scholar
Buckley PF, Schooler NR, Goff DC, Hsiao J, Kopelowicz A, Lauriello J, et al. the PROACTIVE Study. Comparison of SGA oral medications and a long-acting injectable SGA. The PROACTIVE Study. Schizophr Bull. 2015;41:449–59.CrossrefGoogle Scholar
Yu HY, Hsiao CY, Chen KC, Lee LT, Chang WH, Chi MH, et al. A comparison of the effectiveness of risperidone, haloperidol and flupentixol long-acting injections in patients with schizophrenia. A nationwide study. Schizophr Res. 2015;169:400–5.PubMedCrossrefGoogle Scholar
Doshi JA, Pettit AR, Stoddard JJ, Zummo J, Marcus SC. Concurrent oral antipsychotic drug use among schizophrenia patients initiated on long-acting injectable antipsychotics post-hospital discharge. J Clin Psychopharmacol. 2015;35:442–6.PubMedGoogle Scholar
Cordiner M, Shajahan P, McAvoy S, Bashir M, Taylor M. Effectiveness of long-acting antipsychotics in clinical practice: 2. Effects of antipsychotic polypharmacy on risperidone long-acting injection and zuclopenthixol decanoate. Ther Adv Psychopharmacol. 2016;6:66–76.CrossrefPubMedGoogle Scholar
Correll CU, Citrome L, Haddad PM, Lauriello J, Olfson M, Calloway SM, et al. The use of long-acting injectable antipsychotics in schizophrenia: evaluating the evidence. J Clin Psychiatry. 2016;77(Suppl. 3):1–24.CrossrefPubMedGoogle Scholar
Online erschienen: 23.06.2017
Research funding: Authors state no funding involved.
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent is not applicable.
Ethical approval: The conducted research is not related to either human or animals use.