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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi

CiteScore 2018: 2.43

SCImago Journal Rank (SJR) 2018: 0.947
Source Normalized Impact per Paper (SNIP) 2018: 0.837

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Volume 36, Issue 2


Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation

Andrea MastinuORCID iD: https://orcid.org/0000-0002-8862-2896 / Marika Premoli
  • Department of Molecular and Translational Medicine, Section of Pharmacology, University of Brescia, Brescia, Italy
  • Other articles by this author:
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/ Giulia Ferrari-Toninelli
  • Department of Molecular and Translational Medicine, Section of Pharmacology, University of Brescia, Brescia, Italy
  • Istituto Clinico Città di Brescia, Brescia, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Simone Tambaro
  • Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Sweden
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  • De Gruyter OnlineGoogle Scholar
/ Giuseppina Maccarinelli
  • Department of Molecular and Translational Medicine, Section of Pharmacology, University of Brescia, Brescia, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Maurizio Memo
  • Department of Molecular and Translational Medicine, Section of Pharmacology, University of Brescia, Brescia, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Sara Anna Bonini
  • Department of Molecular and Translational Medicine, Section of Pharmacology, University of Brescia, Brescia, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-03-30 | DOI: https://doi.org/10.1515/hmbci-2018-0013


The use of different natural and/or synthetic preparations of Cannabis sativa is associated with therapeutic strategies for many diseases. Indeed, thanks to the widespread diffusion of the cannabinoidergic system in the brain and in the peripheral districts, its stimulation, or inhibition, regulates many pathophysiological phenomena. In particular, central activation of the cannabinoidergic system modulates the limbic and mesolimbic response which leads to food craving. Moreover, cannabinoid agonists are able to reduce inflammatory response. In this review a brief history of cannabinoids and the protagonists of the endocannabinoidergic system, i.e. synthesis and degradation enzymes and main receptors, will be described. Furthermore, the pharmacological effects of cannabinoids will be outlined. An overview of the involvement of the endocannabinoidergic system in neuroinflammatory and metabolic pathologies will be made. Finally, particular attention will also be given to the new pharmacological entities acting on the two main receptors, cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), with particular focus on the neuroinflammatory and metabolic mechanisms involved.

Keywords: Cannabis sativa; endocannabinoids; metabolic syndrome; neuroinflammation


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About the article

Received: 2018-02-02

Accepted: 2018-03-02

Published Online: 2018-03-30

Author Statement

Research funding: The authors state no funding involved.

Conflict of interest: The authors declare no conflict of interest.

Informed consent: Informed consent is not applicable.

Ethical approval: The conducted research is not related to either human or animals use.

Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 36, Issue 2, 20180013, ISSN (Online) 1868-1891, DOI: https://doi.org/10.1515/hmbci-2018-0013.

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