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Hormone Molecular Biology and Clinical Investigation

Editor-in-Chief: Chetrite, Gérard S.

Editorial Board: Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Brodie, Angela / Carruba, Giuseppe / Chen, Shiuan / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Darbre, Philippa D. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Feve, Bruno / Flores-Morales, Amilcar / Foster, Michelle T. / Garcia-Segura, Luis M. / Gastaldelli, Amalia / Gee, Julia M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hampl, Richard / Hilakivi-Clarke, Leena / Hubalek, Michael / Iwase, Hirotaka / Jordan, V. Craig / Klocker, Helmut / Kloet, Ronald / Labrie, Fernand / Mendelson, Carole R. / Mück, Alfred O. / Nicola, Alejandro F. / O'Malley, Bert W. / Raynaud, Jean-Pierre / Ruan, Xiangyan / Russo, Jose / Saad, Farid / Sanchez, Edwin R. / Schally, Andrew V. / Schillaci, Roxana / Schindler, Adolf E. / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutter, Thomas R. / Tresguerres, Jesús A. / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Yu, Qi


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Volume 36, Issue 3

Issues

Impact of adipose tissue on prostate cancer aggressiveness – analysis of a high-risk population

Guila Delouya
  • Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • CRCHUM-Centre de recherche du Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • Other articles by this author:
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/ David Tiberi
  • Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • Other articles by this author:
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/ Sahir R. Bhatnagar
  • Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2, Canada
  • Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste. Catherine, Montreal, QC H3T 1E2, Canada
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/ Shanie Campeau
  • Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, QC, Canada
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/ Fred Saad / Daniel Taussky
  • Corresponding author
  • Department of Radiation Oncology, Centre hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • CRCHUM-Centre de recherche du Centre Hospitalier de l’Université de Montréal, Montréal, QC, Canada
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-11-24 | DOI: https://doi.org/10.1515/hmbci-2018-0049

Abstract

Background

We investigated whether visceral adiposity is associated with more aggressive disease at prostatectomy.

Materials and methods

Four hundred and seventy-four patients referred for postoperative adjuvant or salvage radiotherapy were included in this study. Primary endpoints were positive surgical margins (pSM) or extracapsular extension (ECE). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were manually contoured. Univariate and multivariate logistic regression was performed.

Results

In univariate analysis, VAT volume (p = 0.006), adipose tissue ratio (VAT/SAT, p = 0.003), density of the SAT (p = 0.04), as well as age (p < 0.001) were associated with pSM. In the univariate analysis, SAT density was associated with a trend towards a higher rate of ECE (p = 0.051) but visceral fat volume (p = 0.01), as well as the adipose tissue ratio (p = 0.03) were both protective factors. None of the adipose tissue measurements or BMI had an influence on biochemical recurrence or overall survival (all p ≥ 0.5).

Conclusions

SAT-volume and increased SAT-density were generally associated with more aggressive prostate cancers whereas VAT as a protective factor. These findings emphasize a possible mechanism for the association between obesity and prostate cancer aggressiveness.

Keywords: extracapsular extension; fat density; obesity; positive surgical margins; prostate cancer; visceral fat

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About the article

Received: 2018-07-06

Accepted: 2018-09-11

Published Online: 2018-11-24


Author Statement

Research funding: Authors state no funding involved.

Conflict of interest: Authors state no conflict of interest.

Informed consent: For this retrospective study no informed consent was necessary.

Ethical approval: Local ethics board approval was obtained.


Citation Information: Hormone Molecular Biology and Clinical Investigation, Volume 36, Issue 3, 20180049, ISSN (Online) 1868-1891, DOI: https://doi.org/10.1515/hmbci-2018-0049.

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