Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Human Kinetics

The Journal of Academy of Physical Education in Katowice

4 Issues per year


IMPACT FACTOR 2016: 0.798
5-year IMPACT FACTOR: 1.252

CiteScore 2016: 1.16

SCImago Journal Rank (SJR) 2016: 0.483
Source Normalized Impact per Paper (SNIP) 2016: 0.792

Open Access
Online
ISSN
1899-7562
See all formats and pricing
More options …
Just Accepted

Issues

The Relationships Between Plasma Adrenomedullin and Endothelin-1 Concentrations and Doppler Echocardiographic Indices of Left Ventricular Function During Static Exercise in Healthy Men

Krzysztof Krzemiński
  • Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wiesława Pawłowska-Jenerowicz
  • Outpatient Cardiac Unit for Diagnosis and Therapy, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-07-04 | DOI: https://doi.org/10.2478/v10078-012-0047-z

The Relationships Between Plasma Adrenomedullin and Endothelin-1 Concentrations and Doppler Echocardiographic Indices of Left Ventricular Function During Static Exercise in Healthy Men

Our previous study showed a significant relationships between static exercise-induced changes in plasma adrenomedullin (ADM) and those in endothelin-1 (ET-1), noradrenaline (NA) and pre-ejection period/left ventricular ejection time ratio (PEP/LVET) in older healthy men. It is hypothesized that ADM, ET-1, NA and adrenaline (A) may function as endogenous regulators of cardiac function by modulating myocardial contractility during static exercise. The present study was undertaken to assess the relationships between exercise-induced changes in plasma ADM, ET-1, NA, A concentrations and those in ascending aortic blood flow peak velocity (PV) and mean acceleration (MA) measured by Doppler echocardiography in 24 healthy older men during two 3-min bouts of handgrip at 30% of maximal voluntary contraction, performed alternately with each hand without any break between the bouts. Plasma ADM, ET-1, NA and A as well as heart rate (HR), blood pressure (BP), PV and MA were determined. During handgrip, plasma ADM, ET-1, NA and A as well as HR, BP increased, whereas PV and MA decreased. The increases in plasma ADM correlated positively with those in ET-1, NA and diastolic BP, and correlated negatively with changes in PV (r = -0.68) and MA (r = -0.62). The increases in plasma ET-1 correlated positively with those in NA and BPs and correlated negatively with changes in PV (r= -0.67) and MA (r= -0.60). The results of this study suggest that in healthy older men the exercise-induced changes in plasma ADM, ET 1 and catecholamines are related to alterations in left ventricular contractile state and may co-operatively counteract age-related deterioration of cardiac performance in men.

Keywords: Static handgrip; adrenomedullin; endothelin-1; catecholamines; hemodynamics; Doppler echocardiography

  • Aung-Din R, Mitchell JH, Longhurst JC. Reflex alpha-adrenergic coronary vasoconstriction during hindlimb static exercise in dogs. Circ Res, 1981; 48: 502-509Google Scholar

  • Bamrah VS, Sagar KB, Sheldahl LM, Wann LS Static versus dynamic exercise: effects on Doppler echocardiographic indices of left ventricular performance. Clin Cardiol 1991; 14: 481-488Google Scholar

  • Bäumer AT, Schumann C, Cremers B, Itter G, Linz W, Jockenhövel F, Böhm M. Gene expression of adrenomedullin in failing myocardium: comparison to atrial natriuretic peptide. J Appl Physiol, 2002; 92: 1058-1063Google Scholar

  • Chu L, Zhang JX, Norota I, Endoh M. Receptor subtypes mediating the inotropic effects and Ca2+ signaling induced by endothelin-1 through cross-talk with norepinephrine in canine ventricular myocardium. J Pharm Sci, 2005; 97: 417-428Google Scholar

  • Chu L, Takahashi R, Norota I, Miyamoto T, Takeishi Y, Ishii K, Kubota I, Endoh M. Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. Circ Res, 2003; 92: 1024-1032Google Scholar

  • De Giusti VC, Correa MV, Villa-Abrille MC, Beltrano C, Yeves AM, Chiappe de Cingolani GE, Cingolani HE, Aiello EA. The positive effect of endothelin-1 is mediated by mitochondrial reactive oxygen species. Life Sci, 2008; 83: 264-271Web of ScienceGoogle Scholar

  • Grossman W, McLaurin LP, Saltz SB, Paraskos JA, Dalen JE, Dexter L. Changes in the inotropic state of the left ventricle during isometric exercise. Br Heart J, 1973; 35: 697-703Google Scholar

  • Haynes WG, Webb DJ Endothelin as a regulator of cardiovascular function in health and disease. J Hypertens, 1998; 16: 1081-1098Google Scholar

  • Heath GW, Bloomfield SA. Left ventricular response to graded isometric exercise in patients with coronary heart disease. Clin Physiol, 1982; 2: 215-224Google Scholar

  • Hirayama N, Kitamura K, Imamura T, Kato J, Koiwaya Y, Eto T. Secretion and clearance of the mature form of adrenomedullin in humans. Life Sci, 1999; 64: 2505-2509Google Scholar

  • Ikenouchi H, Kangawa K, Matsuo H, Hirata Y. Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes. Circulation, 1997; 95: 2318-2324Google Scholar

  • Isumi Y, Shoji H, Sugo S, Tochimoto T, Yoshioka M, Kangawa K, Matsuo H, Minamino N. Regulation of adrenomedullin production in rat endothelial cells. Endocrinology, 1998; 139: 838-846Google Scholar

  • Krämer BK, Smith TW, Kelly RA. Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na+-H+ exchanger. Circ Res, 1991; 68: 269-279Google Scholar

  • Krzeminski K, Cybulski G, Nazar K. Relationships between plasma adrenomedullin concentration and systolic time intervals during static handgrip in patients with heart failure. Clin Physiol Funct Imaging, 2009; 29: 114-122Web of ScienceGoogle Scholar

  • Krzeminski K, Cybulski G, Ziemba A, Nazar K. Cardiovascular and hormonal responses to static handgrip in young and older healthy men. Eur J Appl Physiol, 2012; 112: 1315-1325Google Scholar

  • Mac Carthy PA, Grocott-Mason R, Prendergast BD, Shah AM. Contrasting inotropic effects of endogenous endothelin in the normal and failing human heart. Studies with an intracoronary ETA receptor antagonist. Circulation, 2000; 101: 142-147Google Scholar

  • Mangieri E, Tanzilli G, Barillà F, Ciavolella M, Serafini G, Nardi M, Mangiaracina F, Scibilia G, Dell'Italia LJ, Campa PP. Isometric handgrip exercise increases endothelin-1 plasma levels in patients with chronic congestive heart failure. Am J Cardiol, 1997; 79: 1261-1263Google Scholar

  • Mishima K, Kato J, Kuwasako K, Ito K, Imamura T, Kitamura K, Eto T. Effects of endothelin on adrenomedullin secretion and expression of adrenomedullin receptors in rat cardiomyocytes. Biochem Biophys Res Commun, 2001; 287: 264-269Google Scholar

  • Øie E, Vinge LE, Yndestad A, Sandberg C, Grogaard HK, Attramadal H. Induction of a myocardial adrenomedullin signalling system during ischemic heart failure in rats. Circulation, 2000; 101: 415-422Google Scholar

  • Pan CS, Jin SJ, Cao CQ, Zhao J, Zhang J, Wang X, Tang CS, Qi YF. The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation. Peptides, 2007; 28: 900-9009Web of ScienceGoogle Scholar

  • Rhodes J, Udelson JE, Marx GR, Shmid CH, Konstam MA, Hijazi ZM, Bova SA, Fulton DR. A new noninvasive method for the estimation of peak dP/dt. Circulation, 1993; 88: 2693-2699Google Scholar

  • Roessler A, Goswami N, Haditsch B, Hinghofer-Szalkay H. Modulation of plasma adrenomedullin by epinephrine infusion during head up tilt. Eur J Appl Physiol, 2011; 111: 531-537Web of ScienceGoogle Scholar

  • Sato A, Canny BJ, Autelitano DL. Adrenomedullin stimulates cAMP accumulation and inhibits atrial natriuretic peptide gene expression in cardiomyocytes. Biochem Biophys Res Commun, 1995; 230: 311-314Google Scholar

  • Siegel W, Gilbert CA, Nutter DO, Schlant RC, Hurst JW. Use of isometric handgrip for the indirect assessment of left ventricular function in patients with coronary atherosclerotic heart disease. Am J Cardiol, 1972; 30: 48-54Google Scholar

  • Stangl V, Dschietzig T, Bramlage P, Boye P, Kinkel HT, Staudt A, Baumann G, Felix SB, Stangl K. Adrenomedullin and myocardial contractility in the rat. Eur J Pharmacol, 2000; 408: 83-89Google Scholar

  • Szokodi I, Kinnunen P, Tavi P, Weckström M, Toth M, Ruskoaho H Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Circulation, 1998; 97: 1062-1070Google Scholar

  • Takanashi M, Endoh M. Characterization of the positive inotropic effect of endothelin on mammalian ventricular myocardium. Am J Physiol, 1991; 261: H611-H619Google Scholar

  • Tsuruda T, Kato J, Kitamura K, Mishima K, Imamura T, Koiwaya Y, Kangawa K, Eto T. Roles of protein kinase C and Ca2+ dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes. J Hypertens, 2001; 19: 757-763Google Scholar

  • Wallmeyer K, Wann LS, Sagar KB, Czakanski P, Kalbfleisch J, Klopfenstein HS. The effect of changes in afterload on Doppler echocardiographic indexes of left ventricular performance. J Am Soc Echocardiogr, 1988; 1: 135-140Google Scholar

  • Zerkowski HR, Broede A, Kunde K, Hillemann S, Schäfer E, Vogelsang M, Michel MC, Brodde OE. Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium. Arch Pharmacol, 1993; 347: 347-352Google Scholar

About the article


Published Online: 2012-07-04

Published in Print: 2012-06-01


Citation Information: Journal of Human Kinetics, ISSN (Online) 1899-7562, ISSN (Print) 1640-5544, DOI: https://doi.org/10.2478/v10078-012-0047-z.

Export Citation

This content is open access.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Oscar H. M. Lundberg, Lill Bergenzaun, Jörgen Rydén, Mari Rosenqvist, Olle Melander, and Michelle S. Chew
Critical Care, 2016, Volume 20, Number 1

Comments (0)

Please log in or register to comment.
Log in