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International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel

CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

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Volume 30, Issue 1


Persistence of metabolic syndrome and its impact on glucose metabolism in overweight and obese children and adolescents

Anajás da Silva Cardoso Cantalice
  • Corresponding author
  • Department of Nursing, Federal University of Paraiba (UFPB)
  • Bachelor Program in Nursing, Federal University of Campina
  • Street Espírito Santo, 813, apartment 203, Liberdade, Campina Grande-Paraíba, Brazil, Phone: (+5583) 9119 4460
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Inês Fronteira
  • International Health at the Institute of Tropical Medicine and Hygiene, Nova University of Lisbon, Portugal
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jordana de Almeida Nogueira
  • Department of Nursing and Public Health, School of Ribeirão Preto, São Paulo University
  • Department of Clinical Nursing, Federal University of Paraiba, João Pessoa, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Altamira Pereira da Silva Reichert
  • Department of Health of Children and Adolescents, Federal University of Pernambuco
  • Department of Nursing, Federal University of Paraiba, João Pessoa, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Carla Campos Muniz Medeiros
  • Department of Health of Children and Adolescents, State University of Campinas (UNICAMP)
  • Department of Public Health, State University of Paraiba, Campina Grande, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Neusa Collet
  • Department of Nursing of Public Health and Psychiatry of the Health Sciences Centre (DESPP/CCS)
  • Department of Nursing, Federal University of Paraiba (PPGE/UFPB), João Pessoa, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-04-09 | DOI: https://doi.org/10.1515/ijamh-2015-0118



To verify the effects of metabolic syndrome (MS) and its relation to insulin resistance (IR) in children and adolescents with overweight or obesity after 24 months of follow-up.


Studies of repeated measures from April 2009 to April 2012. For both measurements, the evaluations performed were anthropometry, MS diagnosis, fasting blood glucose, glucose homeostasis model assessment (HOMA-IR), and insulin level; at a second evaluation, glycated hemoglobin (HbA1c) was used as an additional indicator of glucose metabolism alterations. Logistic regression between syndrome persistence and its components with glucose metabolism alterations was performed for each of its indicators. The SPSS version 17.0 software (95% CI) was used.


Center for Childhood Obesity, Campina Grande, Brazil.


Children and adolescents (n=133), aged 2–18 years, with overweight or obesity.


There was a significant decrease in MS during the study period, with persistence of the syndrome in 17.3% of the individuals. The presence of at least one alteration in glucose metabolism occurred in 45.1% of children and adolescents. The systolic and diastolic blood pressure, and the average levels of HOMA-IR showed significant decrease at the end of 24 months (p<0.01), and an elevated waist circumference (WC) remained associated with IR (p<0.01).


There was observed no relationship of IR or other indicator of glycemic disorders by persistence of MS. An elevated WC remained associated with IR after controlling for the effects of the following variables: gender, age group, and other MS components.

Keywords: adolescent; children; insulin resistance; metabolic syndrome X; obesity


  • 1.

    Ferreira AP, Ferreira CB, Brito CJ, Pitanga FJG, Moraes CF, et al. Prediction of Metabolic Syndrome in Children by Anthropometric Indicators. Arq Bras Cardiol 2011;96:121–5.PubMedGoogle Scholar

  • 2.

    Cahli GM, Guimarães TT, Oliveira AP. Metabolic syndrome and education school physics. Connections: Faculty of Education magazine Physics of UNICAMP 2013;11:124–43. 1983–9030.Google Scholar

  • 3.

    Costa JA, Balga RSM, Alfenas RCG, Cotta RMM. Promotion of health and diabetes: discussing adherence and motivation of individuals diabetic participants in health programs. Ciênc public health 2011;16:2001–9.Google Scholar

  • 4.

    Malta DC, Silva JB Jr. Brazilian Strategic action plan to combat chronic non-communicable diseases and the global targets set to confront these diseases by 2025: a review. Epidemiol Serv Health 2013;22:151–64.Google Scholar

  • 5.

    Medeiros CCM, Ramos AT, Cardoso MAA, França ISX, Cardoso AS, et al. Insulin resistance and its relationship with the components of the metabolic syndrome. Arq Bras Cardiol 2011;97:380–9.Google Scholar

  • 6.

    Ventura EE, Lane CJ, Weigensber MJ, Toledo-Corral CM, Davis JN, et al. Persistence of the metabolic syndrome over 3 annual visits in overweight Hispanic children: association with progressive risk for type 2 diabetes. J Pediatr 2009;155:535–41.PubMedCrossrefGoogle Scholar

  • 7.

    Ferreira AP, Ferreira CB, Nóbrega OT, Rodrigues Junior E, Use of anthropometric indicators and metabolic prediction of metabolic syndrome in children. R bras Ci e Mov 2011;19:5–14.Google Scholar

  • 8.

    Silva MAM, Rivera IR, Ferraz MRMT, Pinheiro AJT, Alves SWS, et al. Prevalence of cardiovascular risk factors in children and adolescents in the school system of the city of Maceio. Arq Bras Cardiol 2005;84:2573–81.Google Scholar

  • 9.

    Buff CG, Ramos E, Souza FIS, Sarni ROS. Frequency metabolic syndrome in children and adolescents with overweight and obesity. Rev paul Pediatr 2007;25:221–6.Google Scholar

  • 10.

    World Health Organization: The World Health Report 2002: Reducing risks, promoting healthy life. Geneva, Switzerland, 2002.Google Scholar

  • 11.

    Centers of Disease Control and Prevention (CDC). Table for calculated body mass index values for selected heights and weights for ages 2 to 20 years. Developed by the National Center for Health Statistics in collaboration with the National Center for Chronic Disease Prevention and Health Promotion, 2000. Published May 2002, modified 20/04/2001. Available at: htpp://www.cdc.gov/growthcharts. Access October 20, 2014.

  • 12.

    International Diabetes Federation (IDF). Worldwide Definition of Metabolic Syndrome Available at: http://www.idf.org/home/index.cfm?node=1429. Accessed on October 20, 2014.

  • 13.

    Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 2002;106:3143–421.Google Scholar

  • 14.

    Brazilian Society of Cardiology. VI Brazilian Guidelines Arterial hypertension. Arq Bras Cardiol 2010;13. http://dx.doi.org/10.1590/S0066-782X2010001700001.

  • 15.

    American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33:62–9.Google Scholar

  • 16.

    Giuliano ICB, Caramelli B, Pellanda L, Duncan B, Mattos S, Fonseca FH. Brazilian society Cardiology. I Atherosclerosis Prevention Guideline on Childhood and Adolescence. Arq Bras Cardiol 2005;85:1–36.Google Scholar

  • 17.

    Vasques AC, Rosado LE, Cássia G, Alfenas R, Geloneze B. Analysis criticism of the use of indexes Homeostasis Model Assessment (HOMA) in the assessment of insulin resistance and capacity Functional pancreatic b-cells. Arq Bras Endocrinol and Metabol 2008;52:32–9.Google Scholar

  • 18.

    Testa WL. Intervention Effect of exercise in children and obese adolescents. A study review d. EFDeportes.com, Digital magazine. Buenos Aires 2011;16:1. 1514–3465.Google Scholar

  • 19.

    Harder-Lauridsen NM, Birk NM, Ried-Larsen M, Juul A, Andersen LB, et al. A randomized controlled trial on a multicomponent intervention for overweight school-aged children – Copenhagen, Denmark. BMC Pediatrics 2014;14:273.CrossrefPubMedGoogle Scholar

  • 20.

    Poeta LS, Duarte MFS, Caramelli B, Mota J, Giuliano ICB. Effects of physical and nutritional guidance in the exercise profile cardiovascular risk of obese children. Rev Assoc Med Bras 2013;59:56–63.Google Scholar

  • 21.

    Lim S, Jang HC, Park KS, Cho S, Man-Gyoon L, et al. Changes in metabolic syndrome in American and Korean Youth, 1997–2008. Pediatrics 2013;131:214–21.CrossrefGoogle Scholar

  • 22.

    Rocha NP, Siqueira-Catania A, Barros CR, Pires MM, Folchetti LD, et al. Analysis of different anthropometric measurements in metabolic syndrome identification, with or without amendment of glucose metabolism. Arq Bras Endocrinol Metab 2010;54. http://dx.doi.org/10.1590/S0004-27302010000700008.

  • 23.

    Velázquez-López L, Santiago-Dias G, Nava-Hernández J, Muñoz-Torres AV, Medina-Bravo P, et al. Mediterranean-style diet reduces metabolic syndrome components in obese children and adolescents with obesity. BMC Pediatr 2014;14:175–83.CrossrefPubMedGoogle Scholar

  • 24.

    Gobato AO, Vasques ACJ, Zambon MP, Barros Filho AA, Hessel G. Metabolic syndrome and insulin resistance in obese adolescents. Rev Paul Pediatr 2014;32:55–62.CrossrefPubMedGoogle Scholar

  • 25.

    Abella V, Scotece M, Conde J, López V, Lazzaro V, et al. Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res 2014;343:746.Google Scholar

  • 26.

    Magnussen CG, Koskinen J, Juonala M, Chen M, Srinivasan SR, et al. The Diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies. J Am Coll Cardiol 2012;60:1631–9.CrossrefGoogle Scholar

  • 27.

    Mueller NT, Pereira MA, Buitrago-Lopez A, Rodríguez DC, Duran AE, et al. Adiposity indices in the prediction of insulin resistance in prepubertal Colombian children. Public Health Nutr 2013;16:248–55.CrossrefPubMedGoogle Scholar

  • 28.

    Özer S, Yılmaz R, Kazancı NO, Sönmezgöz E, Karaaslan E, et al. Higher HDL levels are a preventive factor for metabolic syndrome in obese Turkish children. Nutr Hosp 2015;31:307–12.Google Scholar

  • 29.

    Carson AP, Reynolds K, Fonseca VA, Muntner P. Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults. Diabetes Care 2010;33:95–7.CrossrefPubMedGoogle Scholar

  • 30.

    Leite N, Milano GE, Cieslak F, Lopes WA, Rodacki A, et al. Effects of physical exercise and nutritional guidance on metabolic syndrome in obese adolescents. Rev Bras Fisioter 2009;13:73–8.CrossrefGoogle Scholar

About the article

Received: 2015-12-04

Accepted: 2016-02-13

Published Online: 2016-04-09

Citation Information: International Journal of Adolescent Medicine and Health, Volume 30, Issue 1, 20150118, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2015-0118.

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