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International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel


CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

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2191-0278
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Volume 30, Issue 1

Issues

Serum ischemia-modified albumin levels in adolescent smokers

Fatih Battal
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Mustafa Tekin
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Hakan Aylanç
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Şule Yıldırım
  • Corresponding author
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
  • Department of Pediatrics, Çanakkale Onsekiz Mart University Hospital, Cumhuriyet Mahallesi, Sahil Yolu No:5, Kepez, Çanakkale, Turkey, Phone: +90-286-2635950, Fax: +90-286-2635956
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/ Hakan Türkön
  • Faculty of Medicine, Department of Biochemistry, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Fatih Köksal Binnetoğlu
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Nazan Kaymaz
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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/ Naci Topaloğlu
  • Faculty of Medicine, Department of Pediatrics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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Published Online: 2016-04-09 | DOI: https://doi.org/10.1515/ijamh-2015-0128

Abstract

Background:

It is known that the biochemical marker linked to tissue ischemia, ischemia-modified albumin (IMA), is related to oxidative stress. Cigarette smoking is a situation with increased oxidative stress causing cell damage and it is thought that many of the negative effects linked to smoking may occur after the biological material in the body is exposed to oxidative damage. This study aimed to identify variability in serum IMA levels in adolescents who smoke.

Methods:

This case-control study comprised 60 adolescents without any chronic disease. The smoking group was 30 adolescents between the ages of 14 and 17 years who smoked, while the control group was 30 healthy adolescents who did not smoke. Blood samples were collected from all subjects and serum IMA levels and serum nicotine metabolites were determined.

Results:

The serum IMA levels in the adolescents who smoked were 0.452±0.094 absorbance unit (ABSU), while the control group had ASBU levels of 0.427±0.054. There was no significant difference between the groups in terms of serum IMA levels (p=0.210). There was a significant difference between the control and smoking groups in terms of serum nicotine metabolite levels (p<0.001).

Conclusions:

Among adolescents who smoke, serum IMA levels may not be a good marker for oxidative stress.

Keywords: adolescents; ischemia-modified albumin; smoking

References

  • 1.

    O’Loughlin J, DiFranza J, Tyndale RF, Meshefedjian G, McMillan-Davey E, et al. Nicotine-dependence symptoms are associated with smoking frequency in adolescents. Am J Prev Med 2003;25:219–25.CrossrefPubMedGoogle Scholar

  • 2.

    Arday DR, Ary DV, Booth M, Dee B, Chaloupka IV FJ, et al. Preventing tobacco use among young people: a report of the surgeon general. US Department of Health and Human Services, Atlanta, GA, 1994.Google Scholar

  • 3.

    Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985;64:111–26.CrossrefPubMedGoogle Scholar

  • 4.

    Pryor WA, Stone K. Oxidants in cigarette smoke radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci 1993;686:27–8.Google Scholar

  • 5.

    Schetter AJ, Heegaard NHH, Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010;31:37–49.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 6.

    Harman D. Free radical theory of aging: an update. Ann N Y Acad 2006;1067:10–21.CrossrefGoogle Scholar

  • 7.

    Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, et al. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 2009:384:366–71.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 8.

    Kirkham PA, Caramori G, Casolari P, Papi AA, Edwards M, et al. Oxidative stress—induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011;184:796–802.CrossrefPubMedGoogle Scholar

  • 9.

    Mahapatra SK, Das S, Dey SK, Somenath R. Smoking induced oxidative stress in serum and neutrophil of the university students. Al Ameen J Med Sci 2008;1:20–31.Google Scholar

  • 10.

    Duarte MM, Rocha JB, Moresco RN, Duarte T, Da Cruz IB, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clin Biochem 2009;42:666–71.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 11.

    Kaefer M, Piva SJ, De Carvalho JA, Da Silva DB, Becker AM, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem 2010;43:450–4.CrossrefWeb of SciencePubMedGoogle Scholar

  • 12.

    Valle Gottlieb MG, DaCruz IB, Duarte MM, Moresco RN, Wiehe M, et al. Associations among metabolic syndrome, ischemia, inflammatory, oxidatives and lipids biomarkers. J Clin Endocrinol Metab 2010;95:586–91.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 13.

    Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes-review and clinical implications. Clin Chem Lab Med 2011;49:177–84.PubMedWeb of ScienceGoogle Scholar

  • 14.

    Cakir M, Karahan SC, Mentese A, Sag E, Cobanoglu U, et al. Ischemia-modified albumin levels in children with chronic liver disease. Gut Liver 2012;6:92–7.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 15.

    Gunduz A, Turkmen S, Turedi S, Mentese A, Yulug E, et al. Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009;16:539–43.Web of SciencePubMedCrossrefGoogle Scholar

  • 16.

    Hacker M, Hoyer HX, La Fougère C, Akcakoyunlu E, Schuhmann C, et al. Effects of peripheral vascular intervention on ischemia-modified albumin. Coron Artery Dis 2007;18:375–9.PubMedCrossrefGoogle Scholar

  • 17.

    SeneŞ M, Kazan N, Coşkun O, Zengi O, Inan L, et al. Oxidative and nitrosative stress in acute ischaemic stroke. Ann Clin Biochem 2007;44:43–7.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 18.

    Ellidag HY, Bulbuller N, Eren E, Abusoglu S, Akgol E, et al. Ischemia-modified albumin: could it be a new oxidative stress biomarker for colorectal carcinoma? Gut Liver 2013;7:675–80.CrossrefWeb of SciencePubMedGoogle Scholar

  • 19.

    Ellidag HY, Eren E, Yilmaz N, Bayindir A. Ischemia modified albumin levels and increased oxidative stress in patients with multiple myeloma. J Med Biochem 2014;33:175–80.Web of ScienceGoogle Scholar

  • 20.

    Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, et al. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem 2004;50:2190–3.CrossrefPubMedGoogle Scholar

  • 21.

    Albarello K, Dos Santos GA, Bochi GV, Sangoi MB, Almeida TC, et al. Ischemia modified albumin and carbonyl protein as potential biomarkers of protein oxidation in hemodialysis. Clin Biochem 2012;45:450–4.Web of SciencePubMedCrossrefGoogle Scholar

  • 22.

    Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006;30:400–18.CrossrefPubMedGoogle Scholar

  • 23.

    Turedi S, Patan T, Gunduz A, Mentese A, Tekinbas C, et al. Ischemia-modified albumin in the diagnosis of pulmonary embolism: an experimental study. Am J Emerg Med 2009;27:635–40.CrossrefWeb of ScienceGoogle Scholar

  • 24.

    Lippi G, Montagnana M, Salvagno GL, Guidi GC. Potential value for new diagnostic markers in the early recognition of acute coronary syndromes. CJEM 2006;8:27–31.CrossrefPubMedGoogle Scholar

  • 25.

    Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt albumin binding and its potential as a marker for myocardial ischemia—A preliminary report. J Emerg Med 2000;19:311–5.CrossrefPubMedGoogle Scholar

  • 26.

    Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44–84.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 27.

    Dundar ZD, Cander B, Gul M, Karabulut KU, Girisgin S. Serum ischemia-modified albumin levels in an experimental acute mesenteric ischemia model. Acad Emerg Med 2010;17:1233–8.Web of ScienceCrossrefGoogle Scholar

  • 28.

    Erem C, Suleyman AK, Civan N, Mentese A, Nuhoglu I, et al. Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocr J 2015;62:493–501.CrossrefPubMedGoogle Scholar

  • 29.

    Toker A, Kucuksen S, Kucuk A, Çicekler H. Serum ischemia-modified albumin and malondialdehyde levels and superoxide dismutase activity in patients with fibromyalgia. Clin Lab 2014;60:1609–15.PubMedWeb of ScienceGoogle Scholar

  • 30.

    Şahinli AS, Marakoğlu K, Kiyici A. Evaluation of the levels of oxidative stress factors and ischemia modified albumin in the cord blood of smoker and non-smoker pregnant women. J Matern Fetal Neonatal Medschetterduarte 2012;25:1064–8.CrossrefGoogle Scholar

About the article

Received: 2015-12-28

Accepted: 2016-02-28

Published Online: 2016-04-09


Conflict of interest statement: All authors listed have contributed sufficiently to the project to be included as authors. To the best of our knowledge, no conflict of interest, financial or other, exists.


Citation Information: International Journal of Adolescent Medicine and Health, Volume 30, Issue 1, 20150128, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2015-0128.

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