Jump to ContentJump to Main Navigation
Show Summary Details
More options …

International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel

CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

See all formats and pricing
More options …
Volume 31, Issue 3


Effect of Melissa officinalis capsule on the mental health of female adolescents with premenstrual syndrome: a clinical trial study

Naval Heydari
  • Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mansure Dehghani
  • Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maasumeh Emamghoreishi
  • Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marzieh Akbarzadeh
  • Corresponding author
  • Nursing and Midwifery College, Namazi Hospital, Shiraz, Iran, Phone: +0711-6474250, Fax: +0711-647425
  • Maternal –Fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-01-25 | DOI: https://doi.org/10.1515/ijamh-2017-0015



In spite of its importance, the psychological health requirements of adolescents are ignored; due to the occurrence of mental disorders in this age group and also public interest in the use of supplementary and alternative treatments such as herbal drugs for mental disorders, this study was carried out aimed at examining the impact of the Melissa officinalis capsule on the psychological health of female adolescents.


In this randomized clinical trial study, 100 female adolescents were assigned to two groups of either drug and placebo groups. The data collection tool includes demographic information recording note and General Health Standard Questionnaire (GHQ). Intervention has been done in the menstrual cycle during 3 successive months and patients received two 600 mg drug daily in the intervention group, and the control group received placebo. After the intervention, the scores of the participants’ psychological health were measured in both groups and data were analyzed through independent t-test using SPSS software version 16.


The study results showed that psychosomatic symptoms score (p < 0.001), anxiety and sleeping disorder (p < 0.001), and social function disorder (p = 0.021) in the experiment group was significantly less than that of the placebo group.


Based on the findings of this study, Melissa officinalis can decrease psychosomatic symptoms, sleeping disorder and anxiety, depression and disorder in social function in female adolescents.

Keywords: adolescents; Melissa officinalis; premenstrual syndrome

  • [1]

    Kieling C, Baker-Henningham H, Belfer M, Conti G, Ertem I, Omigbodun O, et al. Child and adolescent mental health worldwide: evidence for action. The Lancet. 2011;378:1515–25.CrossrefGoogle Scholar

  • [2]

    Brüssow H. What is health? Microb Biotechnol. 2013;6:341–348.CrossrefPubMedGoogle Scholar

  • [3]

    Patel V, Flisher AJ, Hetrick S, McGorry P. Mental health of young people: a global public-health challenge. Lancet. 2007;369:1302–13.Web of ScienceCrossrefPubMedGoogle Scholar

  • [4]

    Lopez A. Disease Control Priorities Project: global burden of disease and risk factors. Washington, DC: Oxford University Press. View Article Google Scholar 2006.Google Scholar

  • [5]

    Borenstein JE, Dean BB, Endicott J, Wong J, Brown C, Dickerson V, et al. Health and economic impact of the premenstrual syndrome. J Reprod Med. 2003;48:515–24.PubMedGoogle Scholar

  • [6]

    Wong LP. Premenstrual syndrome and dysmenorrhea: urban-rural and multiethnic differences in perception, impacts, and treatment seeking. J Pediatr Adolesc Gynecol. 2011;24:272–7.CrossrefWeb of SciencePubMedGoogle Scholar

  • [7]

    Wittchen H-U, Becker E, Lieb R, Krause P. Prevalence, incidence and stability of premenstrual dysphoric disorder in the community. Psychol Med. 2002;32:119–32.PubMedCrossrefGoogle Scholar

  • [8]

    Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev. 2000;4:229–51.PubMedCrossrefGoogle Scholar

  • [9]

    Simon GE, Cherkin DC, Sherman KJ, Eisenberg DM, Deyo RA, Davis RB. Mental health visits to complementary and alternative medicine providers. Gen Hosp Psychiatry. 2004;26:171–7.CrossrefPubMedGoogle Scholar

  • [10]

    Jorm AF, Allen NB, O Donnell CP, Parslow RA, Purcell R, Morgan AJ. Effectiveness of complementary and self-help treatments for depression in children and adolescents. Med J Aust. 2006;185:368.CrossrefPubMedGoogle Scholar

  • [11]

    Soh NL, Walter G. Traditional and alternative medicine treatments in child and adolescent mental health. IACAPAP e-Textbook of Child and Adolescent Mental Health 2015.Google Scholar

  • [12]

    Beaubrun G, Gray GE. A review of herbal medicines for psychiatric disorders. Psychiatr Serv. 2000;51:1130–4.PubMedCrossrefGoogle Scholar

  • [13]

    Abuhamdah S, Chazot PL. Lemon Balm and Lavender herbal essential oils: old and new ways to treat emotional disorders?. Curr Anaesth Crit Care. 2008;19:221–6.CrossrefGoogle Scholar

  • [14]

    Kennedy D, Little W, Haskell CF, Scholey A. Anxiolytic effects of a combination of Melissa officinalis and Valerlana officinalis during laboratory induced stress. Phytother Res 2006;20(2):96–102.PubMedCrossrefGoogle Scholar

  • [15]

    Kennedy D, Scholey AB, Tildesley N, Perry E, Wesnes K. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002;72:953–64.CrossrefPubMedGoogle Scholar

  • [16]

    Alramadhan E, Hanna MS, Hanna MS, Goldstein TG, Avila SM, Weeks BS. Dietary and botanical anxiolytics. Med Sci Monit. 2012;18:RA40–8.PubMedGoogle Scholar

  • [17]

    Krebs K. Complementary healthcare practices: stress management: the complementary alternative medicine approach. Gastroenterol Nurs. 2001;24:261–3.CrossrefGoogle Scholar

  • [18]

    Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21:841–60.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [19]

    Yoo DY, Choi JH, Kim W, Yoo K-Y, Lee CH, Yoon YS, et al. Effects of Melissa officinalis L.(lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus. Neurochem Res. 2011;36:250–7.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [20]

    Bayat M, Tameh AA, Ghahremani MH, Akbari M, Mehr SE, Khanavi M, et al. Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo. DARU J Pharm Sci. 2012;20:42.CrossrefGoogle Scholar

  • [21]

    Hassanzadeh G, Pasbakhsh P, Akbari M, Shokri S, Ghahremani M, Amin G, et al. Neuroprotective properties of Melissa officinalis L. extract against ecstasy-induced neurotoxicity. Cell J (Yakhteh). 2011;13:25–30.Google Scholar

  • [22]

    Goldberg LR. The development of markers for the Big-Five factor structure. Psychol Assess. 1992;4:26.CrossrefGoogle Scholar

  • [23]

    Ebrahimi A, Molavi H, Moosavi G, Bornamanesh A, Yaghobi M. Psychometric properties and factor structure of general health questionnaire 28 (GHQ-28) in Iranian psychiatric patients. J Res Behav Sci. 2007;5:5–12. (Persian).Google Scholar

  • [24]

    Rapkin A, Winer S. Premenstrual syndrome and premenstrual dysphoric disorder: quality of life and burden of illness. Expert Rev Pharmacoecon Outcomes Res. 2009;9:157–70.CrossrefPubMedGoogle Scholar

  • [25]

    Steiner M, Macdougall M, Brown E. The premenstrual symptoms screening tool (PSST) for clinicians. Arch Women’s Ment Health. 2003;6:203–9.CrossrefGoogle Scholar

  • [26]

    Hariri FZ, Moghaddam-Banaem L, Bazi SS, Malehi AS, Montazeri A. The Iranian version of the Premenstrual Symptoms Screening Tool (PSST): a validation study. Arch Women’s Ment Health. 2013;16:531–7.Web of ScienceCrossrefGoogle Scholar

  • [27]

    Alijaniha F, Naseri M, Afsharypuor S, Fallahi F, Noorbala A, Mosaddegh M, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378–84.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [28]

    Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, et al. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014;6:4805–21.Web of SciencePubMedCrossrefGoogle Scholar

  • [29]

    Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. Eur J Med Res. 2004;9:423–31.PubMedGoogle Scholar

  • [30]

    Sarris J, Moylan S, Camfield DA, Pase M, Mischoulon D, Berk M, et al. Complementary medicine, exercise, meditation, diet, and lifestyle modification for anxiety disorders: a review of current evidence. Evid Based Complement Altern Med. 2012;2012:809653.Web of ScienceGoogle Scholar

  • [31]

    Müller S, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006;13:383–7.PubMedCrossrefGoogle Scholar

  • [32]

    Cerny A, Schmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double-blind, placebo-controlled, multicentre study). Fitoterapia. 1999;70:221–8.CrossrefGoogle Scholar

  • [33]

    Taavoni S, Nazem Ekbatani N, Haghani H. The effect of lemon Balm on sleep disorder in menopausal women 60-50 years old. Complement Med J Fac Nurs Midwifery. 2013;2:344–54 [in Persian].Google Scholar

  • [34]

    Cases J, Ibarra A, Feuillere N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterr J Nutr Metab. 2011;4:211–8.CrossrefGoogle Scholar

  • [35]

    Heidari M, Soltanpour A, Naseri M, Kazemnejad A. The effect of Lemon Balm (Melissa Officinalis) on depression in patients after coronary artery bypass graft. Cardiovasc Nurs J. 2015;4:36–43 [in Persian].Google Scholar

  • [36]

    Akbarzadeh M, Dehghani M, Moshfeghy Z, Emamghoreishi M, Tavakoli P, Zare N. Effect of Melissa officinalis capsule on the intensity of premenstrual syndrome symptoms in high school girl students. Nurs Midwifery Stud. 2015;e270014.PubMedGoogle Scholar

  • [37]

    Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay‐guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009;23:1075–81.Web of ScienceCrossrefGoogle Scholar

  • [38]

    López V, Martín S, Gómez-Serranillos MP, Carretero ME, Jäger AK, Calvo MI. Neuroprotective and neurological properties of Melissa officinalis. Neurochem Res. 2009;34:1955–61.Web of ScienceCrossrefPubMedGoogle Scholar

  • [39]

    Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: relarian. Med Sci Monit. 2009;15:RA256–62.PubMedGoogle Scholar

  • [40]

    Jin X, Liu P, Yang F, Zhang Y-h, Miao D. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochem Res. 2013;38:1828–37.Web of ScienceCrossrefGoogle Scholar

  • [41]

    Modaresi M, Basravi M, Sajadia I. Comparative effects of balm hydro alcoholic extract and diazepam on reducing anxiety of in mice. Armaghane Danesh. 2016;20:848–57.Google Scholar

  • [42]

    Taiwo AE, Leite FB, Lucena GM, Barros M, Silveira D, Silva MV, et al. Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: influence of administration and gender. Indian J Pharmacol. 2012;44:189.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [43]

    Limosin F, Ades J. [Psychiatric and psychological aspects of premenstrual syndrome]. L’Encephale. 2000;27:501–8.Google Scholar

  • [44]

    Rapkin AJ, Akopians AL. Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause Int. 2012;18:52–9.PubMedCrossrefGoogle Scholar

  • [45]

    Amin Z, Canli T, Epperson CN. Effect of estrogen-serotonin interactions on mood and cognition. Behav Cogn Neurosci Rev. 2005;4:43–58.PubMedCrossrefGoogle Scholar

  • [46]

    Ballard CG, O Brien JT, Reichelt K, Perry EK. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J Clin Psychiatry. 2002;63:553–8.CrossrefPubMedGoogle Scholar

About the article

Received: 2017-01-27

Accepted: 2017-05-26

Published Online: 2018-01-25

Citation Information: International Journal of Adolescent Medicine and Health, Volume 31, Issue 3, 20170015, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2017-0015.

Export Citation

©2018 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Naval Heydari, Mliheh Abootalebi, Naeimeh Tayebi, Fahimeh Hassanzadeh, Maryam Kasraeian, M Emamghoreishi, and Marzieh Akbarzadeh
Journal of Family Medicine and Primary Care, 2019, Volume 8, Number 9, Page 2990
Naval Heydari, Maliheh Abootalebi, Neda Jamalimoghadam, Maryam Kasraeian, Masoumeh Emamghoreishi, and Marzieh Akbarzaded
International Journal of Gynecology & Obstetrics, 2018

Comments (0)

Please log in or register to comment.
Log in