Jump to ContentJump to Main Navigation
Show Summary Details
More options …

International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel


CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

Online
ISSN
2191-0278
See all formats and pricing
More options …
Ahead of print

Issues

The diurnal pattern of salivary IL-1β in healthy young adults

Nur Basirah Ghazali
  • PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei-Muara, Muara, Brunei Darussalam
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael Steele
  • School of Allied Health, Faculty of Health Sciences, Australian Catholic University, Brisbane, Queensland, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ David Koh
  • PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei-Muara, Muara, Brunei Darussalam
  • Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Adi Idris
  • Corresponding author
  • Menzies Health Institute Queensland, School of Medical Science, Griffith University, Gold Coast, Australia, Phone: +61755527709
  • PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei-Muara, Muara, Brunei Darussalam
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-08-01 | DOI: https://doi.org/10.1515/ijamh-2017-0058

Abstract

Disruption in circadian rhythm affects the production of inflammatory cytokines. Understanding how it behaves in diseased conditions is essential. Despite the role of the interleukin-1β (IL-1β), a potent inflammatory cytokine, in human diseases, little is known about the steady-state circadian rhythm of IL-1β in healthy individuals. This short study investigates the diurnal pattern of salivary IL-1β throughout the day in healthy young adults. Twelve participants provided saliva samples at various times throughout the day. Salivary IL-1β were assessed using enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Salivary IL-1β levels were highest at 0430 h and lowest at 0000 h and shared a similar diurnal pattern to that of salivary IL-6. Western blot analysis showed that these levels correspond to the mature form of IL-1β. Our findings are important as it established the diurnal pattern of salivary IL-1β is fluctuating normally throughout the day. The findings also open an incredible opportunity for developing research conducted in the field with saliva as the diagnostic tool.

Keywords: healthy; interleukin-1β; interleukin-6; saliva; young adult

References

  • [1]

    Salavaty A. Carcinogenic effects of circadian disruption: an epigenetic viewpoint. Chin J Cancer. 2015;34:38.Web of ScienceGoogle Scholar

  • [2]

    Idris A, Ghazali NB, Koh D. Interleukin 1 β – A potential salivary biomarker for cancer progression?. Biomark Cancer. 2015;7:25–9.Google Scholar

  • [3]

    Wong HL, Pfeiffer RM, Fears TR, Vermeulen R, Ji S, Rabkin CS. Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons. Cancer Epidemiol Biomarkers Prev. 2008;17:3450–6.Google Scholar

  • [4]

    Reinhardt ÉL, Fernandes PA, Markus RP, Fischer FM. Daily rhythm of salivary IL-1ß, cortisol and melatonin in day and night workers. Work. 2012;41(Suppl 1):5788–90.Web of ScienceGoogle Scholar

  • [5]

    Izawa S, Miki K, Liu X, Ogawa N. The diurnal patterns of salivary interleukin-6 and C-reactive protein in healthy young adults. Brain Behav Immun. 2013;27:38–41.Web of ScienceGoogle Scholar

About the article

Received: 2017-04-06

Accepted: 2017-05-14

Published Online: 2017-08-01


Conflict of interest: The authors declare that they have no conflict of interest.


Citation Information: International Journal of Adolescent Medicine and Health, 20170058, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2017-0058.

Export Citation

©2017 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Zhewu Wang, Blaine Caughron, and M. Rita I. Young
Frontiers in Psychiatry, 2017, Volume 8

Comments (0)

Please log in or register to comment.
Log in