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International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel


CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

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2191-0278
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Metabolic syndrome, leptin-insulin resistance and uric acid: a trinomial foe for Algerian city-dweller adolescents’ health

Hamida Bouhenni
  • Laboratory of Molecular and Cellular Biology, Faculty of Natural Sciences and Life Sciences, Mentouri Brothers University, Constantine, Algeria
  • Other articles by this author:
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/ Hadjer Daoudi
  • Laboratory of Molecular and Cellular Biology, Faculty of Natural Sciences and Life Sciences, Mentouri Brothers University, Constantine, Algeria
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/ Haidar Djemai
  • IRMES - Institute for Research in bioMedicine and Epidemiology of Sport, Paris, France
  • EA 7329, Paris Descartes University, Sorbonne Paris Cité, Paris, France
  • National Institute of Sport, Expertise and Performance – INSEP, Paris, France
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/ Abdelkader Rouabah
  • Laboratory of Molecular and Cellular Biology, Faculty of Natural Sciences and Life Sciences, Mentouri Brothers University, Constantine, Algeria
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/ Damien Vitiello
  • IRMES - Institute for Research in bioMedicine and Epidemiology of Sport, Paris, France
  • EA 7329, Paris Descartes University, Sorbonne Paris Cité, Paris, France
  • National Institute of Sport, Expertise and Performance – INSEP, Paris, France
  • School of Sport Sciences, Paris Descartes University, Paris, France
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  • De Gruyter OnlineGoogle Scholar
/ Leila Rouabah
  • Corresponding author
  • Faculty of Natural Sciences and Life Sciences, Mentouri Brothers University, Constantine, 1 Ain El Bey Street, 25000, Constantine, Algeria, Tel: +213777065109,
  • Email
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Published Online: 2018-03-28 | DOI: https://doi.org/10.1515/ijamh-2017-0076

Abstract

Background

Adolescence is one of the critical periods where increased risk for long-term obesity-related complications is an important health concern. This highlights the need to perform early diagnostics based on precise biomarkers to decrease the risk of complications in adolescents with obesity.

Objective

To determine the relationships between serum levels of uric acid (UA), leptin and insulin with metabolic syndrome (MS) components in Algerian adolescents.

Subjects

Nondiabetic adolescents (n = 204).

Methods

Blood pressure (BP) and anthropometric measurements were performed using standardized techniques. Blood samples were taken for determination of glycemia, triglyceridemia, uricemia, cholesterolemia, leptinemia and insulinemia.

Results

The rate of MS among an excess weight group was 17.4% [95% confidence interval (CI)]. Serum levels of UA, leptin and insulin were significantly higher in the excess weight group compared to a normal weight group (279.4 ± 86.05 vs. 204.9 ± 50.34 μmol/L and 25.65 ± 14.01 vs. 4.09 ± 2.60 μg/L, p < 0.001; 24.58 ± 13.85 vs. 13.34 ± 6.41 μIU/L, p < 0.05). Serum levels of UA, leptin and insulin were significantly higher in adolescents with MS compared to those without MS (304.86 ± 111.41 vs. 224.72 ± 77.81 μmol/L, 30.26 ± 12.46 vs. 16.93 ± 14.97 μg/L and 30.91 ± 17.30 vs. 18.71 ± 10.14 μIU/L, p < 0.05, respectively). Significant correlations were found between UA and leptin with waist circumference (r = 0.50 and 0.76), diastolic blood pressure (r = 0.58 and 0.43), triglycerides (r = 0.42 and 0.35) and high-density lipoprotein-cholesterol (r = −0.36 and −0.35).

Conclusion

Serum levels of UA and leptin may be useful biomarkers for early diagnosis of the risk of MS in our Algerian adolescent population.

Keywords: adolescents; metabolic hormones; metabolic syndrome; obesity; uric acid

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About the article

aDamien Vitiello and Leila Rouabah contributed equally to this work.


Received: 2017-05-02

Accepted: 2017-06-20

Published Online: 2018-03-28


Conflict of interest statement: The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.


Citation Information: International Journal of Adolescent Medicine and Health, 20170076, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2017-0076.

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