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International Journal of Adolescent Medicine and Health

Editor-in-Chief: Merrick, Joav

Editorial Board: Birch, Diana ML / Blum, Robert W. / Greydanus, MD, Dr. HC (Athens), Donald E. / Hardoff, Daniel / Kerr, Mike / Levy, Howard B / Morad, Mohammed / Omar, Hatim A. / de Paul, Joaquin / Rydelius, Per-Anders / Shek, Daniel T.L. / Sher, Leo / Silber, Tomas J. / Towns, Susan / Urkin, Jacob / Verhofstadt-Deneve, Leni / Zeltzer, Lonnie / Tenenbaum, Ariel

CiteScore 2018: 0.79

SCImago Journal Rank (SJR) 2018: 0.350
Source Normalized Impact per Paper (SNIP) 2018: 0.476

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Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials

Sharron L. Docherty
  • Corresponding author
  • Duke University, School of Nursing, 307 Trent Drive, DUMC 3322, Durham, NC 27710, USA, Phone: (+919) 668-3836
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stacey Crane / Joan E. Haase / Sheri L. Robb
Published Online: 2019-04-11 | DOI: https://doi.org/10.1515/ijamh-2018-0215


Participation of adolescents and young adults (AYAs) with cancer in randomized clinical trials (RCTs) is necessary to advance treatments and psychosocial programs. Exploring AYAs experiences in an RCT will inform strategies to support recruitment and retention. A qualitative design was used to study the experiences of 13 AYAs in the Stories and Music for Adolescent and Young Adult Resilience during Transplant I (SMART I) trial. Key themes included: Weighing the Pros and Cons; Randomization Preferences; Completing Measures; and Worthwhile Experience. The experiences of AYAs during RCTs can bring insights that inform the design and management of AYA trials. Strategies include improving assent/consent processes, design of electronic interfaces and encouraging researcher flexibility.

Keywords: adolescents; cancer; clinical trials; research experiences; research participation; young adults


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About the article

Received: 2018-09-16

Accepted: 2018-11-29

Published Online: 2019-04-11

Funding Source: National Institutes of Nursing Research

Award identifier / Grant number: R01 NR008583

Funding Source: National Cancer Institute

Award identifier / Grant number: U10 CA098543

Research reported in this publication was supported by the National Institutes of Nursing Research (Funder Id: http://dx.doi.org/10.13039/100000056, R01 NR008583), the National Cancer Institute (Funder Id: http://dx.doi.org/10.13039/100000054, U10 CA098543), and the second author’s National Cancer Institute career development award (T32 CA117865). Content is the authors sole responsibility and does not necessarily represent the official views of the National Institutes of Health.

Clinical Trials.gov Identifier: NCT01556256.

Citation Information: International Journal of Adolescent Medicine and Health, 20180215, ISSN (Online) 2191-0278, DOI: https://doi.org/10.1515/ijamh-2018-0215.

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