Jump to ContentJump to Main Navigation
Show Summary Details
More options …

The International Journal of Biostatistics

Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.

IMPACT FACTOR 2018: 1.309

CiteScore 2018: 1.11

SCImago Journal Rank (SJR) 2018: 1.325
Source Normalized Impact per Paper (SNIP) 2018: 0.715

Mathematical Citation Quotient (MCQ) 2018: 0.03

See all formats and pricing
More options …

Modeling the Effect of Alzheimer's Disease on Mortality

Elizabeth Johnson / Ron Brookmeyer / Kathryn Ziegler-Graham
Published Online: 2007-12-21 | DOI: https://doi.org/10.2202/1557-4679.1083

Mortality rate ratios and the associated proportional hazards models have been used to summarize the effect of Alzheimer's disease on longevity. However, the mortality rate ratios vary by age and therefore do not provide a simple parsimonious summary of the effect of the disease on lifespan. Instead, we propose a new parameter that is defined by an additive multistate model. The proposed multistate model accounts for different stages of disease progression. The underlying assumption of the model is that the effect of disease on mortality is to add a constant amount to death rates once the disease progresses from an early to late stage. We explored the properties of the proposed model; in particular the behavior of the mortality rate ratio and median survival that is induced by the model. We combined information from several data sources to estimate the parameter in our model. We found that the effect of Alzheimer's disease on longevity is to increase the absolute annual risk of death by about 8% once a person progressed to late stage disease. Most importantly, we find that this additive effect is the same regardless of the patients' age or gender. Thus, the proposed additive multi-state model provides a parsimonious and clinically interpretable description of the effects of Alzheimer's disease on mortality.

Keywords: Alzheimer’s; mortality; multi-state; survival

About the article

Published Online: 2007-12-21

Citation Information: The International Journal of Biostatistics, Volume 3, Issue 1, ISSN (Online) 1557-4679, DOI: https://doi.org/10.2202/1557-4679.1083.

Export Citation

©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

K. G. Goozee, T. M. Shah, H. R. Sohrabi, S. R. Rainey-Smith, B. Brown, G. Verdile, and R. N. Martins
British Journal of Nutrition, 2016, Volume 115, Number 3, Page 449
Ron Brookmeyer, Nada Abdalla, Claudia H. Kawas, and María M. Corrada
Alzheimer's & Dementia, 2017
Tzeyu L. Michaud, Robert L. Kane, J. Riley McCarten, Joseph E. Gaugler, John A. Nyman, and Karen M. Kuntz
PharmacoEconomics - Open, 2017
Haihong Xue, Qianqian Sun, Long Liu, Liye Zhou, Ruifeng Liang, Runlian He, and Hongmei Yu
Comprehensive Psychiatry, 2017, Volume 78, Page 91
Ming-Min Chung, Christopher J. Nicol, Yi-Chuan Cheng, Kuan-Hung Lin, Yen-Lin Chen, Dee Pei, Chien-Hung Lin, Yi-Nuo Shih, Chia-Hui Yen, Shiang-Jiuun Chen, Rong-Nan Huang, and Ming-Chang Chiang
Experimental Cell Research, 2017, Volume 352, Number 1, Page 75
Martin Tobias, Li-Chia Yeh, and Elizabeth Johnson
Australian & New Zealand Journal of Psychiatry, 2008, Volume 42, Number 9, Page 828
D. Salas-Gonzalez, J. M. Górriz, J. Ramírez, I. A. Illán, M. López, F. Segovia, R. Chaves, P. Padilla, and C. G. Puntonet
Medical Physics, 2010, Volume 37, Number 11, Page 6084
Nicholas P. Jewell
Clinical Pharmacology & Therapeutics, 2016, Volume 100, Number 4, Page 353
Sam Norton, Fiona E Matthews, and Carol Brayne
BMC Public Health, 2013, Volume 13, Number 1
Marcus R. Keogh-Brown, Henning Tarp Jensen, H. Michael Arrighi, and Richard D. Smith
EBioMedicine, 2016, Volume 4, Page 184
Giuseppe Verdile, Stephanie J. Fuller, and Ralph N. Martins
Neurobiology of Disease, 2015, Volume 84, Page 22
Hiroyuki Watanabe, Masahiro Ono, and Hideo Saji
The Scientific World Journal, 2015, Volume 2015, Page 1
R Chaves, J M Górriz, J Ramírez, I A Illán, D Salas-Gonzalez, and M Gómez-Río
Physics in Medicine and Biology, 2011, Volume 56, Number 18, Page 6047
Sam Norton, Fiona E Matthews, Deborah E Barnes, Kristine Yaffe, and Carol Brayne
The Lancet Neurology, 2014, Volume 13, Number 8, Page 788
F.J. Martínez-Murcia, J.M. Górriz, J. Ramírez, C.G. Puntonet, and D. Salas-González
Expert Systems with Applications, 2012, Volume 39, Number 10, Page 9676
Diego Salas-Gonzalez, Juan M. Górriz, Javier Ramírez, Miriam López, Ignacio A. Illan, Fermín Segovia, Carlos G. Puntonet, and Manuel Gómez-Río
Neuroscience Letters, 2009, Volume 461, Number 1, Page 60
J.M. Górriz, F. Segovia, J. Ramírez, A. Lassl, and D. Salas-Gonzalez
Applied Soft Computing, 2011, Volume 11, Number 2, Page 2313
Elizabeth Colantuoni, Greg Surplus, Andre Hackman, H. Michael Arrighi, and Ron Brookmeyer
Alzheimer's & Dementia, 2010, Volume 6, Number 5, Page 425

Comments (0)

Please log in or register to comment.
Log in