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The International Journal of Biostatistics

Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.

IMPACT FACTOR 2018: 1.309

CiteScore 2018: 1.11

SCImago Journal Rank (SJR) 2018: 1.325
Source Normalized Impact per Paper (SNIP) 2018: 0.715

Mathematical Citation Quotient (MCQ) 2018: 0.03

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Joint Analysis of Current Status and Marker Data: An Extension of a Bivariate Threshold Model

Xingwei Tong / Xin He / Jianguo Sun / Mei-Ling T Lee
Published Online: 2008-10-16 | DOI: https://doi.org/10.2202/1557-4679.1122

This paper considers joint analysis of current status and marker data using a threshold model based on first hitting times. A failure time is defined as the time at which a subject's latent health status process first decreases to zero. We extend the bivariate Wiener process model in Whitmore et al. (1998) to the case when only current status data are available. We develop maximum likelihood estimation procedures and provide simulation studies. We apply our methods to a motivating example involving liver tumors in mice.

Keywords: bivariate Wiener process; current status data; first-hitting-time model; health status process; joint analysis; marker process

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Published Online: 2008-10-16

Citation Information: The International Journal of Biostatistics, Volume 4, Issue 1, ISSN (Online) 1557-4679, DOI: https://doi.org/10.2202/1557-4679.1122.

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