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The International Journal of Biostatistics

Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.

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IMPACT FACTOR 2017: 0.840
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1557-4679
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Model Checking with Residuals for g-estimation of Optimal Dynamic Treatment Regimes

Benjamin Rich / Erica E. M. Moodie / David A Stephens / Robert W Platt
Published Online: 2010-03-05 | DOI: https://doi.org/10.2202/1557-4679.1210

In this paper, we discuss model checking with residual diagnostic plots for g-estimation of optimal dynamic treatment regimes. The g-estimation method requires three different model specifications at each treatment interval under consideration: (1) the blip model; (2) the expected counterfactual model; and (3) the propensity model. Of these, the expected counterfactual model is especially difficult to specify correctly in practice and so far there has been little guidance as to how to check for model misspecification. Residual plots are a useful and standard tool for model diagnostics in the classical regression setting; we have adapted this approach for g-estimation. We demonstrate the usefulness of our approach in a simulation study, and apply it to real data in the context of estimating the optimal time to stop breastfeeding.

Keywords: dynamic treatment regimes; optimal dynamic regimes; g-estimation; model checking; residuals

About the article

Published Online: 2010-03-05


Citation Information: The International Journal of Biostatistics, Volume 6, Issue 2, ISSN (Online) 1557-4679, DOI: https://doi.org/10.2202/1557-4679.1210.

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[1]
Gabrielle Simoneau, Erica E M Moodie, Robert W Platt, and Bibhas Chakraborty
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[3]
Michael P Wallace, Erica EM Moodie, and David A Stephens
Statistical Methods in Medical Research, 2017, Volume 26, Number 4, Page 1641
[4]
Benjamin Rich, Erica EM Moodie, and David A Stephens
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[5]
Ashkan Ertefaie, Susan Shortreed, and Bibhas Chakraborty
Statistics in Medicine, 2016, Volume 35, Number 13, Page 2221
[6]
Benjamin Rich, Erica E. M. Moodie, and David A. Stephens
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Michael P. Wallace and Erica E. M. Moodie
Biometrics, 2015, Volume 71, Number 3, Page 636
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