The International Journal of Biostatistics
Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.
2 Issues per year
IMPACT FACTOR 2016: 0.500
5-year IMPACT FACTOR: 0.862
CiteScore 2016: 0.42
SCImago Journal Rank (SJR) 2016: 0.488
Source Normalized Impact per Paper (SNIP) 2016: 0.467
Mathematical Citation Quotient (MCQ) 2016: 0.09
Pearl’s article provides a useful springboard for discussing further the benefits and drawbacks of principal stratification and the associated discomfort with attributing effects to post-treatment variables. The basic insights of the approach are important: pay close attention to modification of treatment effects by variables not observable before treatment decisions are made, and be careful in attributing effects to variables when counterfactuals are ill-defined. These insights have often been taken too far in many areas of application of the approach, including instrumental variables, censoring by death, and surrogate outcomes. A novel finding is that the usual principal stratification estimand in the setting of censoring by death is by itself of little practical value in estimating intervention effects.
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