Jump to ContentJump to Main Navigation
Show Summary Details
More options …

The International Journal of Biostatistics

Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.

2 Issues per year


IMPACT FACTOR 2016: 0.500
5-year IMPACT FACTOR: 0.862

CiteScore 2016: 0.42

SCImago Journal Rank (SJR) 2016: 0.488
Source Normalized Impact per Paper (SNIP) 2016: 0.467

Mathematical Citation Quotient (MCQ) 2016: 0.09

Online
ISSN
1557-4679
See all formats and pricing
More options …

Designs Combining Instrumental Variables with Case-Control: Estimating Principal Strata Causal Effects

Russell T. Shinohara / Constantine E. Frangakis / Elizabeth Platz / Konstantinos Tsilidis
Published Online: 2012-01-06 | DOI: https://doi.org/10.2202/1557-4679.1355

The instrumental variables framework is commonly used for the estimation of causal effects from cohort samples. However, the combination of instrumental variables with more efficient designs such as case-control sampling requires new methodological consideration. For example, as the use of Mendelian randomization studies is increasing and the cost of genotyping and gene expression data can be high, the analysis of data gathered from more cost-effective sampling designs is of prime interest. We show that the standard instrumental variables analysis does not appropriately estimate the causal effects of interest when the instrumental variables design is combined with the case-control design. We also propose a method that can estimate the causal effects in such combined designs. We illustrate the method with a study in oncology.

Keywords: case-control; instrumental variables; Mendelian randomization; principal stratification; study design

About the article

Published Online: 2012-01-06


Citation Information: The International Journal of Biostatistics, ISSN (Online) 1557-4679, DOI: https://doi.org/10.2202/1557-4679.1355.

Export Citation

©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Konstantinos K. Tsilidis, Stefania I. Papatheodorou, Evangelos Evangelou, and John P. A. Ioannidis
JNCI: Journal of the National Cancer Institute, 2012, Volume 104, Number 24, Page 1867
[2]
Alicia Garcia-Anguita, Artemisia Kakourou, and Konstantinos K. Tsilidis
Current Colorectal Cancer Reports, 2015, Volume 11, Number 5, Page 250

Comments (0)

Please log in or register to comment.
Log in