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International Journal of Chemical Reactor Engineering

Ed. by de Lasa, Hugo / Xu, Charles Chunbao

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Volume 14, Issue 1


Volume 9 (2011)

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Volume 7 (2009)

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Volume 1 (2002)

Preparation of Chitosan based Nanofibers: Optimization and Modeling

K. Thirugnanasambandham
  • Corresponding author
  • Department of Chemical Engineering, AC Tech Campus, Anna University, Chennai 600025, Tamil Nadu, India
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/ V. Sivakumar
Published Online: 2015-12-01 | DOI: https://doi.org/10.1515/ijcre-2015-0029


The main objective of the present study is to prepare a chitosan based nanofiber and model the electrospinning process using response surface methodology (RSM). The electrospinning parameters such as collector distance, polymer solution concentration and applied voltage were optimized by using three-variable-three-level Box–Behnken design (BBD). Based on RSM analysis, second order polynomial equation was formed and it indicated good correspondence between experimental and predicted values. 3D response surface plots were used to study the individual and interactive effects of process variables on chitosan based nanofiber diameter. The optimum process conditions for the minimum chitosan based nanofiber diameter (0.3 µm) were found to be collector distance of 12 cm, polymer solution concentration of 25% and applied voltage of 6 kV.

Keywords: chitosan; nanofiber; electrospinning; Box-Behnken design; optimization


  • 1. Agarwal, S., Wendorff, J.H., Greiner, A., 2008. Use of electrospinning technique for biomedical applications. Polymer 49, 5603–5621.Google Scholar

  • 2. Banik, R.M., Santhiagu, A., Upadhyay, S.N., 2007. Optimization of nutrients for gellan gum production by sphingomonas paucimobilis ATCC-31461 in molassebased medium using response surface methodology. Bio-resources Technology 98, 792–797.Google Scholar

  • 3. Deniz, B., Merve, H., Sermin, E., Erdal, K., 2012. Comparison of the results of response surface methodology and artificial neural network for the biosorption of lead using black cumin. Bioresource Technology 112, 111–115.Web of ScienceGoogle Scholar

  • 4. Ferreira, S.L.C., Bruns, R.E., da Silva, E.G.P., dos Santos, W.N.L., Quintella, C.M., David, J.M., de Andrade, J.B., Breitkreitz, M.C., Jardim, I.C.S.F., Neto, B.B., 2007. Statistical designs and response surface techniques for the optimization of chromatographic systems. Journal of Chromatography A 1158, 2–14.Google Scholar

  • 5. Geng, X.Y., Kwon, O.H., Jang, J.H., 2005. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26, 5427–5432.Google Scholar

  • 6. Ji, L., Medford, A.J., Zhang, X., 2009. Electrospun polyacrylonitrile/zinc chloride composite nanofibers and their response to hydrogen sulfide. Polymer 50, 605–612.Google Scholar

  • 7. Klossner, R.R., Queen, H.A., Coughlin, A.J., Krause, W.E., 2008. Correlation of chitosan’s reological properties and its ability to electrospun. Biomacromolecules 9, 2947–2953.Google Scholar

  • 8. Min, B.M., Lee, S.W., Lim, J.N., You, Y., Lee, T.S., Kang, P.H., 2004. Chitin and chitosan nanofibers: Electrospinning of chitin and deacetylation of chitin nanofibers. Polymer 45, 7137–7142.Google Scholar

  • 9. Muzzarelli, R.A.A., 1996. Chitin: Metal ion chelation and enzyme immobilization, in: J. C. Salamone (Ed.), The Polymeric Materials Encyclopedia. CRC Press, Inc., Boca Raton, FL, USA, pp. 295–300.Google Scholar

  • 10. Tir, M., Moulai-Mostefa, N., 2008. Optimization of oil removal from oily wastewater by electrocoagulation using response surface method. Journal of Hazardous Materials 158, 107–115.Web of ScienceGoogle Scholar

  • 11. Torres-Giner, S., Ocio, M.J., Lagaron, J.M., 2008. Development of active antimicrobial fiber based chitosan polysaccharide nanostructures using electrospinning. Engineering in Life Sciences 8, 303–314.Web of ScienceCrossrefGoogle Scholar

About the article

Published Online: 2015-12-01

Published in Print: 2016-02-01

Citation Information: International Journal of Chemical Reactor Engineering, Volume 14, Issue 1, Pages 283–288, ISSN (Online) 1542-6580, ISSN (Print) 2194-5748, DOI: https://doi.org/10.1515/ijcre-2015-0029.

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