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International Journal on Disability and Human Development

Official journal of the the National Institute of Child Health and Human Development in Israel

Editor-in-Chief: Merrick, Joav

Editorial Board Member: Brooks, Tony / Carmeli, BPT, Eliezer / Caron, MPH, Rosemary M. / Davidson, Philip W / Galil, Ahron / Heller, Tamar / Huff, Marlene B. / Janicki, Matthew P. / Kerr, Mike / Levy, Howard B / Lindström, Bengt / Morad, Mohammed / Omar, Hatim A. / Postolache, Teodor T. / Prasher, Vee / Shek, Daniel T.L. / Sher, Leo / Stratakis, Constantine A

4 Issues per year


CiteScore 2016: 0.25

SCImago Journal Rank (SJR) 2016: 0.179
Source Normalized Impact per Paper (SNIP) 2016: 0.234

Online
ISSN
2191-0367
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Volume 9, Issue 4 (Dec 2010)

Issues

White matter and oligodendrocyte abnormalities in bipolar disorder

William Byne
  • Mount Sinai School of Medicine, New York, NY, USA
  • James J. Peters Veterans’ Administration Medical Center, New York, NY, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ David C. Kerns / Leo Sher
  • Mount Sinai School of Medicine, New York, NY, USA
  • James J. Peters Veterans’ Administration Medical Center, New York, NY, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Vladan Novakovic
  • Mount Sinai School of Medicine, New York, NY, USA
  • James J. Peters Veterans’ Administration Medical Center, New York, NY, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-11-29 | DOI: https://doi.org/10.1515/IJDHD.2010.036

Abstract

Psychiatric brain research has historically focused on gray matter due, in part, to difficulties inherent in white matter studies. Recent innovations have greatly facilitated white matter research, and abnormalities of myelin, and the oligodendrocytes that elaborate it, have been described in psychotic and mood disorders, including bipolar disorder. The overlap of white matter findings among these disorders is not surprising given their overlap in symptoms, but the degree of apparent overlap could be exaggerated by a high rate of false positive findings among neuroimaging studies that have examined the whole brain rather than particular regions of interest. Future research should focus on the white matter tracts that interconnect the brain regions most consistently implicated in each disorder. Myelin integrity is crucial for efficient and rapid conduction of neuronal impulses. Thus, white matter abnormalities could disrupt the temporal convergence of neural inputs to regions of integration and contribute to dysregulation within the cortico-limbic circuits implicated in bipolar disorder.

Keywords: bipolar disorder; gene expression; myelin; neuroimaging; oligodendrocyte; schizophrenia; unipolar depression

About the article

Corresponding author: William Byne, MD, PhD, Research Bldg, Room 2F39, James J. Peters Veterans’ Administration Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA


Received: 2010-08-01

Accepted: 2010-09-17

Published Online: 2010-11-29

Published in Print: 2010-12-01


Citation Information: International Journal on Disability and Human Development, ISSN (Online) 2191-0367, ISSN (Print) 2191-1231, DOI: https://doi.org/10.1515/IJDHD.2010.036.

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