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International Journal of Occupational Medicine and Environmental Health

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Ototoxicity of Organic Solvents - From Scientific Evidence to Health Policy

Mariola Śliwinska-Kowalska1 / Deepak Prasher1 / Célia Rodrigues1 / Ewa Zamysłowska-Szmytke1 / Pierre Campo1 / Donald Henderson1 / Sören Lund1 / Ann-Christin Johnson1 / Michael Schäper1 / Lars Ödkvist1 / Jukka Starck1 / Esko Toppila1 / Elke Schneider1 / Claes Möller1 / Adrian Fuente1 / Kamakshi Gopal1

Department of Physical Hazards and Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Łódź, Poland1

University College, London, UK2

Marie Curie Fellowships, Nofer Institute of Occupational Medicine, Łódź, Poland3

Institut National de Recherche et de Sécurité, Vandoeuvre, France4

Center for Hearing and Deafness, SUNY, Buffalo, New York, USA5

National Research Centre for the Working Environment, Copenhagen, Denmark6

Karolinska Institutet, Stockholm, Sweden7

Institut für Arbeitsphysiologie an der Universität, Dortmund, Germany8

University Hospital, Linköping, Sweden9

Finnish Institute of Occupational Health, Helsinki, Finland10

European Agency for Safety and Health at Work, Bilbao, Spain11

Sahlgrenska University Hospital, Gothenburg, Sweden12

The University of Hong Kong, Hong Kong13

University of North Texas, Denton, USA14

This content is open access.

Citation Information: International Journal of Occupational Medicine and Environmental Health. Volume 20, Issue 2, Pages 215–222, ISSN (Online) 1896-494X, ISSN (Print) 1232-1087, DOI: https://doi.org/10.2478/v10001-007-0021-5, July 2007

Publication History

Published Online:

Ototoxicity of Organic Solvents - From Scientific Evidence to Health Policy

The scientific workshop, organized under the 6th European Framework Programme, the Marie Curie Host Fellowship for the Transfer of Knowledge "NoiseHear" Project, by the Nofer Institute of Occupational Medicine (Łódź, Poland, 15-16 November 2006), gathered world specialists in noise, chemicals, and ototoxicity, including hearing researchers, toxicologists, otolaryngologists, audiologists and occupational health physicians.

The workshop examined the evidence and the links between isolated exposure to organic solvents, combined exposure to noise and solvents, and effects on the auditory system. Its main purpose was to review the key scientific evidence to gather the necessary knowledge for developing adequate occupational health policies. This paper summarizes the workshop sessions and subsequent discussions.

Keywords: Toluene; Styrene; Mixtures; Noise; Dose-response relationship; Occupational exposure limits (OEL)

  • Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss.Ear Hear 2006;27(1):1-19. [PubMed] [Crossref]

  • Campo P, Loquet G, Blachère V, Roure M. Toluene and styrene intoxication route in the rat cochlea.Neurotox Teratol 1999;21(4):427-34. [Crossref]

  • Campo P, Lataye R, Loquet G, Bonnet P. Styrene-induced hearing loss: a membrane insult.Hear Res 2001;154(1/2):170-80. [Crossref] [PubMed]

  • Lataye R, Campo P, Loquet G. Combined effects of noise and styrene exposure on hearing function.Hear Res 2000;139:86-96. [Crossref] [PubMed]

  • Campo P, Blachère V, Payan JP, Cossec B, Ducos P. Toluene toxicokinetics and metabolism parameters in the rat and guinea pig.Environ Toxicol Pharmacol 2006;21:276-82. [PubMed] [Crossref]

  • Ramsey J, Andersen M. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.Toxicol Appl Pharmacol 1984;73(1):159-75. [PubMed] [Crossref]

  • Lataye R, Campo P, Loquet G, Morel G. Combined effects of noise and styrene on hearing: comparison between active and sedentary rats. Noise Health 2005;7:27:49-64.

  • Loquet G, Campo P, Lataye R. Comparison of toluene-induced and styrene-induced hearing loss.Neurotoxicology and Teratology 1999;21:689-97. [Crossref] [PubMed]

  • Gagnaire F, Langlais C. Relative ototoxicity of 21 aromatic solvents.Arch Toxicol 2005;79:346-54. [Crossref] [PubMed]

  • Lund SP, Jepsen GB, Simonsen L. Effects of long-term, low-level noise exposure on hearing thresholds, DPOAE, and suppression of DPOAE in rats.Noise Health 2001;12:33-43.

  • Johnson AC, Juntunen L, Nylén P, Borg E, Höglund G. Effect of interaction between noise and toluene on auditory function in the rat.Acta Otolaryngol (Stockh) 1988;105:56-63. [PubMed] [Crossref]

  • Lataye R, Campo P. Combined effects of simultaneous exposure to noise and toluene on hearing function.Neurotox Teratol 1997;19:373-82. [Crossref]

  • Brandt-Lassen R, Lund SP, Jepsen GB. Rats exposed to Toluene and Noise may develop Loss of Auditory Sensitivity due to Synergistic Interaction.Noise&Health 2000;3(9):33-44.

  • Makitie AA, Pirvola U, Pyykko I, Sakakibara H, Riihimaki V, Ylikoski J. The ototoxic interaction of styrene and noise.Hear Res 2003;179:9-20. [Crossref] [PubMed]

  • Loquet G, Campo P, Lataye R, Cossec B, Bonnet P. Combined effects of exposure to styrene and ethanol on the auditory function in the rat.Hear Res 2000;148:173-80. [PubMed] [Crossref]

  • Dennison JE, Bigelow PL, Andersen ME. Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose.Toxicol Ind Health 2004;20 (6-10):165-75. [Crossref] [PubMed]

  • Davis RR, Murphy WJ, Snawder JE, Striley CA, Henderson D, Khan A, et al. Susceptibility to the ototoxic properties of toluene is species specific.Hear Res 2002;166:24-32. [Crossref] [PubMed]

  • Lataye R, Campo P, Pouyatos B, Cossec B, Blachere V, Morel G. Solvent ototoxicity in the rat and guinea pig.Neurotoxicol Teratol 2003;25:39-50. [Crossref] [PubMed]

  • Morata TC, Dunn DE, Kretschmer LW, Lemasters GK, Keith RW. Effects of occupational exposure to organic solvents and noise on hearing.Scand J Work Environ Health 1993;19(4):245-54. [Crossref] [PubMed]

  • Jacobsen P, Hein HO, Suadicani P, Parving A, Glytelberg F. Mixed solvent exposure and hearing impairment: an epidemiological study of 3284 men. The Copenhagen male study.Occup Med 1993;43:180-4. [Crossref]

  • Morata TC, Dunn DE, Sieber WK. Occupational exposure to noise and ototoxic organic solvents.Arch Environ Health 1994;49(5):359-65. [PubMed] [Crossref]

  • Morata TC, Engel T, Durao A, Costa TRS, Krieg EF, Dunn DE, et al. Hearing loss from combined exposures among petroleum refinery workers.Scand Audiol 1997;26:141-9. [Crossref] [PubMed]

  • Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Dudarewicz A, et al. Hearing loss among workers exposed to moderate concentration of organic solvents.Scand J Work Environ Health 2001;27(5):335-42. [Crossref]

  • Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W. Effects of coexposure to noise and mixture of organic solvents on hearing in dockyard workers.J Occup Environ Med 2004;46:30-8. [Crossref]

  • Kim J, Park H, Ha E, Jung T, Paik N, Yang S. Combined effects of noise and mixed solvents exposure on hearing function among workers in the aviation industry.Ind Health 2005;43:567-73. [Crossref] [PubMed]

  • Kaufman LR, LeMasters GK, Olsen DM, Succop P. Effects of concurrent noise and jet fuel exposure on hearing loss.J Occup Environ Med 2005;47:212-8. [PubMed] [Crossref]

  • Niklasson M, Arlinger S, Ledin T, Möller C, Ödkvist L, Flodin U, et al. Audiological disturbances caused by long-term exposure to industrial solvents. Relation to the diagnosis of toxic encephalopathy.Scand Audiol 1998;27(3):131-6. [PubMed] [Crossref]

  • Ödkvist LM, Arlinger SD, Edling C, Larsby B, Bergholtz LM. Audiological and vestibulo-oculomotor findings in workers exposed to solvents and jet fuel.Scand Audiol 1987;16:75-81. [PubMed] [Crossref]

  • Laukli E, Hansen PW. An audiometric test battery for the evaluation of occupational exposure to industrial solvents.Acta Oto-Laryngol 1995;115(2):162-4. [Crossref]

  • Morata TC, Johnson AC, Nylen P, Svensson EB, Cheng J, Krieg EK, et al. Audiometric findings in workers exposed to low levels of styrene and noise.J Occup Environ Med 2002;44(9):806-14. [Crossref] [PubMed]

  • Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Wesolowski W, et al. Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise.J Occup Environ Med 2003;4515-24.

  • Muijser H, Hoogendijk EM, Hooisma J. The effects of occupational exposure to styrene on high-frequency hearing thresholds.Toxicology 1988;49:331-40. [Crossref] [PubMed]

  • Morioka I, Miyai N, Yamamoto H, Miyashita K. Evaluation of combined effect of organic solvents and noise by the upper limit of hearing.Ind Health 2000;38(2):252-7. [Web of Science] [Crossref] [PubMed]

  • Möller C, Ödkvist L, Larsby B, Tham R, Ledin T, Bergholtz LM. Otoneurological findings in workers exposed to styrene.Scand J Work Environ Health 1990;16:189-94. [PubMed] [Crossref]

  • Calabrese G, Martini A, Sessa G, Cellini M, Bartolucci GB, Marcuzzo G, et al. Otoneurological study of workers exposed to styrene in the fiberglass industry.Int Arch Occup Environ Health 1996;68:219-23. [Crossref] [PubMed]

  • Johnson AC, Morata TC, Lindblad AC, Nylen PR, Svensson EB, Krieg EK, et al. Audiological findings in workers exposed to styrene alone or in concert with noise.Noise Health 2006;8(30):45-57. [PubMed] [Crossref]

  • Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, Kotylo P, Fiszer M, Wesolowski W, et al. Exacerbation of noise-induced hearing loss by co-exposure to workplace chemicals.Environ Toxicol Pharmacol 2005;19:547-53. [Crossref]

  • Hoffmann J, Ihrig A, Hoth S, Triebig G. Field study to explore possible effects of styrene on auditory function in exposed workers.Ind Health 2006;44(2):283-6. [Crossref] [PubMed]

  • Morata TC, Fiorini AC, Fischer FM, et al. Toluene-induced hearing loss among rotogravure printing workers.Scand J Work Environ Health 1997;23(4):289-98. [Crossref] [PubMed]

  • Schäper M, Demes P, Zupanic M, Blaszkewicz M, Seeber A. Occupational toluene exposure and auditory function: results from a follow-up study.Ann Occup Hyg 2003;47:493-502. [PubMed] [Crossref]

  • Sass-Kortsak AM, Corey PN, Robertson JM. An investigation of the association between exposure to styrene and hearing loss.Ann Epidemiol 1995;5(1):15-24. [Crossref]

  • Toppila E, Pyykkö I, Starck J, Kaksonen R, Ishizaki, H. Individual risk factors in the development of noise-induced hearing loss.Noise Health 2000;2(8):59-70. [PubMed]

  • Starck J, Pyykkö I, Toppila E, Pekkarinen J. Do the models assess noise-induced hearing loss correctly?ACES 1996;7(3-4):21-6.

  • Starck J, Toppila E, Pyykkö I. Impulse noise and risk criteria.Noise Health 2003;5(20):63-73. [PubMed]

  • Campo P, Maguin K. Solvent-induced hearing loss: mechanisms and prevention strategy.Int J Occup Med Environ Health. In press 2007.

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