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Inflammasome

Editor-in-Chief: Pelegrin, Pablo

Ed. by Lopez-Castejón, Gloria

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Emerging Science

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2300-102X
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New insights in caspase-11 functions in noncanonical inflammasome signalling

Mélanie Bodnar
  • INSERM U1052, Centre de Recherche en Cancerologie de Lyon, F-69000 Lyon, France
  • Universite de Lyon, F-69000 Lyon, France
  • Universite Lyon 1, ISPB, Lyon, F-69622, France, F-69000 Lyon, France
  • CNRS UMR5286, Centre de Recherche en Cancerologie de Lyon, F-69000 Lyon, France
  • Centre Leon Berard, F-69008 Lyon, France
/ Virginie Petrilli
  • Corresponding author
  • INSERM U1052, Centre de Recherche en Cancerologie de Lyon, F-69000 Lyon, France
  • Universite de Lyon, F-69000 Lyon, France
  • Universite Lyon 1, ISPB, Lyon, F-69622, France, F-69000 Lyon, France
  • CNRS UMR5286, Centre de Recherche en Cancerologie de Lyon, F-69000 Lyon, France
  • Centre Leon Berard, F-69008 Lyon, France
  • Email:
Published Online: 2014-04-23 | DOI: https://doi.org/10.2478/infl-2014-0001

Abstract

Inflammasomes are multi-protein complexes that play a crucial role in innate immunity. They are assembled by cytosolic sensors of the Nucleotide-binding domain and Leucine-rich repeat containing Receptor (NLR) and PYrin and HIN (PYHIN) domain-containing protein families upon sensing various pathogens and danger signals. Inflammasome formation culminates in caspase-1 activation, which causes the cleavage of pro-IL-1β and pro- IL-18 into active cytokines; this eventually results in the induction of an inflammatory cell death called pyroptosis. Recent data using Gram-negative bacteria suggests a role for caspase-11 not only in NLRP3 inflammasome activation but also in a caspase-1- and inflammasome-independent cell death. This novel caspase-11-dependent pathway is critical to control infection by Gram-negative bacteria and has been named the noncanonical inflammasome.

Keywords : caspase-1; cell death; cytosolic LPS; IL-1b; inflammasome

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About the article

Received: 2013-10-21

Accepted: 2014-01-17

Published Online: 2014-04-23

Published in Print: 2014-01-01


Citation Information: Inflammasome, ISSN (Online) 2300-102X, DOI: https://doi.org/10.2478/infl-2014-0001.

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© 2014 Mélanie Bodnar, Virginie Petrilli. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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