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Inflammasome: a new villain in heart disease

Chiara Sonnino
  • Corresponding author
  • VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stefano Toldo
  • VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
  • Victoria Johnson Research Laboratory, Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eleonora Mezzaroma
  • VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
  • Victoria Johnson Research Laboratory, Virginia Commonwealth University, Richmond, VA, USA
  • Department of Pharmacotherapy and Outcome Studies, School of Pharmacy - Virginia Commonwealth University, Richmond, VA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonio Abbate
  • VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
  • Victoria Johnson Research Laboratory, Virginia Commonwealth University, Richmond, VA, USA
  • James C. Roberts Esq. Professor of Cardiology, Virginia Commonwealth University, 1200 E. Broad Street, Box 980281, Richmond, VA, 23298, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-12 | DOI: https://doi.org/10.2478/infl-2014-0003


Many cardiac diseases have an inflammatory component by which the initial injury is amplified by an overzealous inflammatory response leading to further tissue injury, and impairing the recovery of cardiac function. The formation of the inflammasome in the heart represents a newly identified amplifying step in the pathogenesis and pathophysiology of different cardiovascular conditions. Initial experimental animal studies and small pilot clinical studies suggest that targeting the inflammasome in its different components interrupts this amplification process and promotes more favorable healing. The inflammasome represents therefore a new villain in the fight against heart disease.

Keywords: Sterile Inflammation; Inflammasome; Heart Diseases


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About the article

Received: 2014-02-24

Accepted: 2014-04-03

Published Online: 2014-06-12

Citation Information: Inflammasome, ISSN (Online) 2300-102X, DOI: https://doi.org/10.2478/infl-2014-0003.

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©2014 Chiara Sonnino et al. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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