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Journal of Apicultural Science

The Journal of Research Institute of Horticulture and Apicultural Research Association

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Chemical composition and antioxidant activity of beebread, and its influence on the glioblastoma cell line (U87MG)

Renata Markiewicz-Żukowska
  • Department of Bromatology, Medical University of Białystok, Poland
/ Sylwia K. Naliwajko
  • Department of Bromatology, Medical University of Białystok, Poland
/ Emilia Bartosiuk
  • Department of Bromatology, Medical University of Białystok, Poland
/ Justyna Moskwa
  • Department of Bromatology, Medical University of Białystok, Poland
/ Valery Isidorov
  • Institute of Chemistry, University of Białystok, Poland
/ Jolanta Soroczyńska
  • Department of Bromatology, Medical University of Białystok, Poland
/ Maria H. Borawska
  • Corresponding author
  • Department of Bromatology, Medical University of Białystok, Poland
  • Email:
Published Online: 2013-12-31 | DOI: https://doi.org/10.2478/jas-2013-0025


Beebread is processed pollen stored in the cells of the honeycomb, with the addition of various enzymes and honey, which undergoes lactic acid fermentation. Ethanolic extracts (EBBs) were obtained from three different samples of beebread from Poland. Assays were carried out for the determination of chemical composition (GC/MS), for the total phenolic content, and for the antioxidant and cytotoxic activities. The effects of beebread extracts (10, 20, 30, 50, 100 μg/mL) on the viability of the glioblastoma cell line (U87MG) were studied after 24 h, 48 h, and 72 h. Our results indicated a time-dependent inhibitory effect on the viability of U87MG cells treated EBB. The main inhibitory effect of EBB was observed after 72 h; EBB treatment decreased cell viability to 49 - 66%.

Keywords: antioxidant activity; beebread; chemical composition; cytotoxicity; glioblastoma multiforme

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About the article

Published Online: 2013-12-31

Published in Print: 2013-12-01

Citation Information: Journal of Apicultural Science, ISSN (Print) 2299-4831, DOI: https://doi.org/10.2478/jas-2013-0025. Export Citation

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