Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

6 Issues per year


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

Online
ISSN
2191-0286
See all formats and pricing
More options …
Volume 23, Issue 1

Issues

Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of Lagenaria breviflora

Adebowale B. Saba
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Omowumi M. Onakoya
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ademola A. Oyagbemi
  • Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-02-22 | DOI: https://doi.org/10.1515/jbcpp-2011-0034

Abstract

Background: This study was designed to investigate the hepatoprotective and in vivo antioxidant effects of the ethanol extract of whole fruit of Lagenaria breviflora (LB) in experimental animals.

Methods: Forty nine Wistar albino rats were divided into seven groups of seven. Group I served as the control group; rats in Group II were given i.p. carbon tetrachloride (CCL4) (1.5 mL/kg) alone; Groups III–VI received different concentrations of plant extract (100, 250 and 500 mg/kg) with CCL4 and Group VII received kolaviron (KV) at 200 mg/kg as a reference hepatoprotective agent.

Results: There was a significant (p<0.05) increase in malondialdehyde (MDA) and hydrogen peroxide (H202) generation in the serum of CCL4 treated rats (Group II) while the serum glutathione (GSH) level decreased significantly. Pretreatment with LB extract led to a significant (p<0.05) increase in serum GSH and a significant (p<0.05) reduction in MDA and H2O2generation. The activities of marker enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin, creatinine and blood urea nitrogen (BUN) increased (p<0.05) significantly in CCL4 treated rats (Group II).

Conclusions: The present study suggested that treatment with LB extract enhances the recovery from CCL4 induced hepatic damage and oxidative stress via its antioxidant and hepatoprotective properties.

Keywords: antioxidant; CCL4; hepatoprotective; Lagenaria breviflora; oxidative stress

About the article

Corresponding author: Ademola A. Oyagbemi, Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria Phone: +2348033639776, Fax: +028103043


Received: 2011-10-14

Accepted: 2012-01-16

Published Online: 2012-02-22

Published in Print: 2012-03-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 23, Issue 1, Pages 27–32, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2011-0034.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, and Muhammad Ali
Evidence-Based Complementary and Alternative Medicine, 2017, Volume 2017, Page 1
[2]
Zhen Li, Wei Wei, Bohong Chen, Gaotai Cai, Xin Li, Ping Wang, Jinping Tang, and Wenqi Dong
Scientific Reports, 2016, Volume 6, Number 1
[3]
Mami Morikawa, Yu Ando, Asami Kita, Marie Sugita, Saki Matsumura, and Masaaki Terashima
Food Science and Technology Research, 2014, Volume 20, Number 6, Page 1221
[4]
Hor-Yue Tan, Serban San-Marina, Ning Wang, Ming Hong, Sha Li, Lei Li, Fan Cheung, Xiao-Yan Wen, and Yibin Feng
Evidence-Based Complementary and Alternative Medicine, 2016, Volume 2016, Page 1
[5]
Abolfazl Dadkhah, Faezeh Fatemi, Mahdi Alipour, Sanaz Fatourehchi, and Fatemeh Sadat Parchini
Journal of Essential Oil Bearing Plants, 2015, Volume 18, Number 2, Page 335
[6]
N.S. Baligar, R.H. Aladakatti, Mukhtar Ahmed, and M.B. Hiremath
Canadian Journal of Physiology and Pharmacology, 2014, Volume 92, Number 4, Page 267

Comments (0)

Please log in or register to comment.
Log in