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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

6 Issues per year


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

Online
ISSN
2191-0286
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Volume 23, Issue 1

Issues

Two types of cochlear hair cells with two different modes of activation are better than one

Haim Sohmer
  • Department of Medical Neurobiology (Physiology), Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
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Published Online: 2012-01-11 | DOI: https://doi.org/10.1515/jbcpp-2011-0036

Abstract

The hair cells are the receptor cells of the inner ear. There is still controversy concerning the mechanism of their activation. Studies on the hair cells of the bullfrog sacculus have provided much information on the activity of hair cells. However, the mammalian cochlea has two different types of hair cells – the inner hair cells (IHCs) and the outer hair cells (OHCs) – and it is likely that their activation mechanisms are not identical. Mechanical manipulations of the cochlea and measurements of the passive and active displacements of the basilar membrane in the normal and postmortem cochleas provide evidence that the OHCs are activated directly by the fluid pressures induced in the cochlea by low-level sound, and not indirectly by a passive traveling wave. The activated OHCs produce active displacements (the cochlear amplifier) which excite the IHCs, probably by deflecting their stereocilia, followed by excitation of the auditory nerve fibers.

Keywords: basilar membrane; cochlear amplifier; fluid pressures; inner hair cell; outer hair cell; passive traveling wave

About the article

Corresponding author: Prof. Haim Sohmer, Department of Medical Neurobiology (Physiology), Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel Phone: +972-2-6758385, Fax: +972-2-6439736


Received: 2011-10-26

Accepted: 2011-12-04

Published Online: 2012-01-11

Published in Print: 2012-03-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 23, Issue 1, Pages 1–3, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2011-0036.

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