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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board Member: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

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CiteScore 2016: 1.01

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Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 24, Issue 4 (Nov 2013)

Issues

Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats

Ademola A. Oyagbemi
  • Corresponding author
  • Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria
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/ Temitayo O. Omobowale
  • Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria
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/ Ibraheem O. Azeez
  • Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria
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/ John O. Abiola
  • Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria
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/ Rahamon A.M. Adedokun
  • Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria
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/ Helen O. Nottidge
  • Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria
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Published Online: 2013-03-18 | DOI: https://doi.org/10.1515/jbcpp-2012-0061

Abstract

Background: This study was conducted to investigate toxicological effects associated with prolonged consumption of Moringa oleifera leaves as a beverage.

Methods: Thirty rats were used in this study. They were grouped into five groups of six rats. Rats in group I received 2 mL/kg body weight (b.w.) of corn oil (vehicle). Animals in groups II, III, IV and V received 50, 100, 200 and 400 mg/kg b.w. of methanolic extract of M. oleifera (MEMO) for 8 weeks. Serum collected was analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, blood urea nitrogen (BUN) and creatinine.

Results: There was a significant (p<0.05) increase in serum total protein and globulin in a dose-dependent manner. Rats that received MEMO at 200 and 400 mg/kg b.w. showed a significant (p<0.05) increase in serum ALT, AST, BUN and creatinine which pointed to hepatic and kidney damage. All experimental animals that received MEMO had a significant (p<0.05) increase in body weight in a dose-dependent manner.

Conclusions: This study therefore confirms for the first time that chronic administration of M. oleifera leaves might predispose to hepatic and kidney damage.

Keywords: kidney; liver; Moringa oleifera; toxicity assessment

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About the article

Corresponding author: Ademola A. Oyagbemi, Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria, Phone: +2348033639776, Fax: +234028103043, E-mail:


Received: 2012-10-10

Accepted: 2013-02-24

Published Online: 2013-03-18

Published in Print: 2013-11-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2012-0061.

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