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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

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CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 25, Issue 2

Issues

Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole

Chiagoziem A. Otuechere
  • Corresponding author
  • Division of Biochemistry, Department of Chemical Sciences, Redeemer’s University, Mowe, Ogun State, Nigeria
  • Email
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/ Gbemisola Madarikan
  • Division of Biochemistry, Department of Chemical Sciences, Redeemer’s University, Mowe, Ogun State, Nigeria
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  • De Gruyter OnlineGoogle Scholar
/ Tinuala Simisola
  • Division of Biochemistry, Department of Chemical Sciences, Redeemer’s University, Mowe, Ogun State, Nigeria
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  • De Gruyter OnlineGoogle Scholar
/ Olubukola Bankole
  • Division of Biochemistry, Department of Chemical Sciences, Redeemer’s University, Mowe, Ogun State, Nigeria
  • Other articles by this author:
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/ Adeleke Osho
Published Online: 2013-11-28 | DOI: https://doi.org/10.1515/jbcpp-2013-0059

Abstract

Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is a broad-spectrum antibiotic. However, its use is associated with toxic reactions. Virgin coconut oil (VCO), derived from coconut, has been widely used throughout history for its medicinal value. The aim of this study was to investigate the beneficial actions of VCO against TMP-SMX-induced alterations in serum biochemical end points.

Methods: Twenty rats were divided into four groups. Group 1 (control) received no drug, whereas group 2 received TMP-SMX (8/40 mg/kg) twice daily for 7 days. Group 3 was administered coconut oil at a dose of 600 mg/kg body weight per day. The last group was treated with TMP-SMX (8/40 mg/kg) and coconut oil (600 mg/kg) simultaneously. Blood samples were collected from all groups on the 8th day of the experiment for measurement of serum biochemical parameters. Organ weights and coefficients were also evaluated.

Results: TMP-SMX caused a significant (p<0.05) increase in the levels of serum total bilirubin, lactate dehydrogenase, and alkaline phosphatase by 192%, 67%, and 41%, respectively, relative to controls. This was followed by a significant reduction in triglyceride and relative kidney weight by 40% and 7%, respectively. There were no significant differences (p>0.05) in the activities of serum aminotransferases, total acid phosphatase, γ-glutamyl transferase, uric acid, cholesterol, albumin, and urea levels. Supplementation of VCO ameliorated TMP-SMX-induced effects by restoring the levels of total bilirubin, alkaline phospahatase, and lactate dehydrogenase.

Conclusions: The results of this study demonstrate that the active components of coconut oil had protective effects against the toxic effects induced by TMP-SMX administration, especially in the liver of rats.

Keywords: anti-folate; coconut oil; kidney; liver; serum biochemistry; testis; trimethoprim-sulfamethoxazole

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About the article

Corresponding author: Chiagoziem A. Otuechere, Biochemistry Unit, Department of Chemical Sciences, Redeemer’s University, Km 46, Lagos-Ibadan Expressway, Redemption City, Mowe, Ogun State, 234, Nigeria, E-mail:


Received: 2013-05-08

Accepted: 2013-10-29

Published Online: 2013-11-28

Published in Print: 2014-05-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 25, Issue 2, Pages 249–253, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2013-0059.

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